The Intestinal Microbiome Primes Host Innate Immunity against Enteric Virus Systemic Infection through Type I Interferon

While cumulative data indicate that indigenous commensal bacteria can facilitate enteric virus infection, little is known regarding whether intestinal microbes have a protective role in antagonizing enteric systemic infection by modulating host innate immunity. Although accumulating literature has...

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Autores principales:	Xiao-Lian Yang, Gan Wang, Jin-Yan Xie, Han Li, Shu-Xian Chen, Wei Liu, Shu Jeffrey Zhu
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/492107ee793845ff8dd09166961a6ae0
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spelling	oai:doaj.org-article:492107ee793845ff8dd09166961a6ae02021-11-03T21:15:03ZThe Intestinal Microbiome Primes Host Innate Immunity against Enteric Virus Systemic Infection through Type I Interferon2150-751110.1128/mBio.00366-21https://doaj.org/article/492107ee793845ff8dd09166961a6ae02021-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00366-21https://doaj.org/toc/2150-7511 While cumulative data indicate that indigenous commensal bacteria can facilitate enteric virus infection, little is known regarding whether intestinal microbes have a protective role in antagonizing enteric systemic infection by modulating host innate immunity. Although accumulating literature has pointed out that the microbiota has a fundamental impact on host systemic antiviral innate immune responses mediated by type I interferon (IFN), only a few specific commensal bacteria species have been revealed to be capable of regulating IFN-I and ISG expression, not to mention the underlying mechanisms.Xiao-Lian YangGan WangJin-Yan XieHan LiShu-Xian ChenWei LiuShu Jeffrey ZhuAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Xiao-Lian Yang Gan Wang Jin-Yan Xie Han Li Shu-Xian Chen Wei Liu Shu Jeffrey Zhu The Intestinal Microbiome Primes Host Innate Immunity against Enteric Virus Systemic Infection through Type I Interferon
description	While cumulative data indicate that indigenous commensal bacteria can facilitate enteric virus infection, little is known regarding whether intestinal microbes have a protective role in antagonizing enteric systemic infection by modulating host innate immunity. Although accumulating literature has pointed out that the microbiota has a fundamental impact on host systemic antiviral innate immune responses mediated by type I interferon (IFN), only a few specific commensal bacteria species have been revealed to be capable of regulating IFN-I and ISG expression, not to mention the underlying mechanisms.
format	article
author	Xiao-Lian Yang Gan Wang Jin-Yan Xie Han Li Shu-Xian Chen Wei Liu Shu Jeffrey Zhu
author_facet	Xiao-Lian Yang Gan Wang Jin-Yan Xie Han Li Shu-Xian Chen Wei Liu Shu Jeffrey Zhu
author_sort	Xiao-Lian Yang
title	The Intestinal Microbiome Primes Host Innate Immunity against Enteric Virus Systemic Infection through Type I Interferon
title_short	The Intestinal Microbiome Primes Host Innate Immunity against Enteric Virus Systemic Infection through Type I Interferon
title_full	The Intestinal Microbiome Primes Host Innate Immunity against Enteric Virus Systemic Infection through Type I Interferon
title_fullStr	The Intestinal Microbiome Primes Host Innate Immunity against Enteric Virus Systemic Infection through Type I Interferon
title_full_unstemmed	The Intestinal Microbiome Primes Host Innate Immunity against Enteric Virus Systemic Infection through Type I Interferon
title_sort	intestinal microbiome primes host innate immunity against enteric virus systemic infection through type i interferon
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/492107ee793845ff8dd09166961a6ae0
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The Intestinal Microbiome Primes Host Innate Immunity against Enteric Virus Systemic Infection through Type I Interferon

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