MiR-497∼195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1α activity
H-type endothelium, defined by the high expression of CD31 and endomucin, is found in the bone where it promotes angiogenesis and osteogensis. Here Yanget al. show that the miR-497∼195 cluster regulates the generation and maintenance of the H-type endothelium by controlling the levels of Notch regul...
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Nature Portfolio
2017
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oai:doaj.org-article:49210989904743bb805bd34eb5fb257a2021-12-02T15:36:58ZMiR-497∼195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1α activity10.1038/ncomms160032041-1723https://doaj.org/article/49210989904743bb805bd34eb5fb257a2017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16003https://doaj.org/toc/2041-1723H-type endothelium, defined by the high expression of CD31 and endomucin, is found in the bone where it promotes angiogenesis and osteogensis. Here Yanget al. show that the miR-497∼195 cluster regulates the generation and maintenance of the H-type endothelium by controlling the levels of Notch regulator Fbxw7 and the HIF regulator P4HTM.Mi YangChang-Jun LiXi SunQi GuoYe XiaoTian SuMan-Li TuHui PengQiong LuQing LiuHong-Bo HeTie-Jian JiangMin-Xiang LeiMei WanXu CaoXiang-Hang LuoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Mi Yang Chang-Jun Li Xi Sun Qi Guo Ye Xiao Tian Su Man-Li Tu Hui Peng Qiong Lu Qing Liu Hong-Bo He Tie-Jian Jiang Min-Xiang Lei Mei Wan Xu Cao Xiang-Hang Luo MiR-497∼195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1α activity |
| description |
H-type endothelium, defined by the high expression of CD31 and endomucin, is found in the bone where it promotes angiogenesis and osteogensis. Here Yanget al. show that the miR-497∼195 cluster regulates the generation and maintenance of the H-type endothelium by controlling the levels of Notch regulator Fbxw7 and the HIF regulator P4HTM. |
| format |
article |
| author |
Mi Yang Chang-Jun Li Xi Sun Qi Guo Ye Xiao Tian Su Man-Li Tu Hui Peng Qiong Lu Qing Liu Hong-Bo He Tie-Jian Jiang Min-Xiang Lei Mei Wan Xu Cao Xiang-Hang Luo |
| author_facet |
Mi Yang Chang-Jun Li Xi Sun Qi Guo Ye Xiao Tian Su Man-Li Tu Hui Peng Qiong Lu Qing Liu Hong-Bo He Tie-Jian Jiang Min-Xiang Lei Mei Wan Xu Cao Xiang-Hang Luo |
| author_sort |
Mi Yang |
| title |
MiR-497∼195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1α activity |
| title_short |
MiR-497∼195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1α activity |
| title_full |
MiR-497∼195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1α activity |
| title_fullStr |
MiR-497∼195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1α activity |
| title_full_unstemmed |
MiR-497∼195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1α activity |
| title_sort |
mir-497∼195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial notch and hif-1α activity |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/49210989904743bb805bd34eb5fb257a |
| work_keys_str_mv |
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| _version_ |
1718386286685847552 |