Altered spatial summation optimizes visual function in axial myopia

Abstract This study demonstrates significant differences between the area of complete spatial summation (Ricco’s area, RA) in eyes with and without non-pathological, axial myopia. Contrast thresholds were measured for six stimuli (0.01–2.07 deg2) presented at 10º eccentricity in 24 myopic subjects a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Victoria Stapley, Roger S. Anderson, Kathryn J. Saunders, Pádraig J. Mulholland
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4923422294014fbfa141208938a517ff
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4923422294014fbfa141208938a517ff
record_format	dspace
spelling	oai:doaj.org-article:4923422294014fbfa141208938a517ff2021-12-02T16:26:36ZAltered spatial summation optimizes visual function in axial myopia10.1038/s41598-020-67893-82045-2322https://doaj.org/article/4923422294014fbfa141208938a517ff2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-67893-8https://doaj.org/toc/2045-2322Abstract This study demonstrates significant differences between the area of complete spatial summation (Ricco’s area, RA) in eyes with and without non-pathological, axial myopia. Contrast thresholds were measured for six stimuli (0.01–2.07 deg2) presented at 10º eccentricity in 24 myopic subjects and 20 age-similar non-myopic controls, with RA estimated using iterative two-phase regression analysis. To explore the effects of axial length-induced variations in retinal image size (RIS) on the measurement of RA, refractive error was separately corrected with (i) trial lenses at the anterior focal point (near constant inter-participant RIS in mm), and (ii) contact lenses (RIS changed with axial length). For spectacle corrected measurements, RA was significantly larger in the myopic group, with a significant positive correlation also being observed between RA and measures of co-localised peripheral ocular length. With contact lens correction, there was no significant difference in RA between the groups and no relationship with peripheral ocular length. The results suggest RA changes with axial elongation in myopia to compensate for reduced retinal ganglion cell density. Furthermore, as these changes are only observed when axial length induced variations in RIS are accounted for, they may reflect a functional adaptation of the axially-myopic visual system to an enlarged RIS.Victoria StapleyRoger S. AndersonKathryn J. SaundersPádraig J. MulhollandNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Victoria Stapley Roger S. Anderson Kathryn J. Saunders Pádraig J. Mulholland Altered spatial summation optimizes visual function in axial myopia
description	Abstract This study demonstrates significant differences between the area of complete spatial summation (Ricco’s area, RA) in eyes with and without non-pathological, axial myopia. Contrast thresholds were measured for six stimuli (0.01–2.07 deg2) presented at 10º eccentricity in 24 myopic subjects and 20 age-similar non-myopic controls, with RA estimated using iterative two-phase regression analysis. To explore the effects of axial length-induced variations in retinal image size (RIS) on the measurement of RA, refractive error was separately corrected with (i) trial lenses at the anterior focal point (near constant inter-participant RIS in mm), and (ii) contact lenses (RIS changed with axial length). For spectacle corrected measurements, RA was significantly larger in the myopic group, with a significant positive correlation also being observed between RA and measures of co-localised peripheral ocular length. With contact lens correction, there was no significant difference in RA between the groups and no relationship with peripheral ocular length. The results suggest RA changes with axial elongation in myopia to compensate for reduced retinal ganglion cell density. Furthermore, as these changes are only observed when axial length induced variations in RIS are accounted for, they may reflect a functional adaptation of the axially-myopic visual system to an enlarged RIS.
format	article
author	Victoria Stapley Roger S. Anderson Kathryn J. Saunders Pádraig J. Mulholland
author_facet	Victoria Stapley Roger S. Anderson Kathryn J. Saunders Pádraig J. Mulholland
author_sort	Victoria Stapley
title	Altered spatial summation optimizes visual function in axial myopia
title_short	Altered spatial summation optimizes visual function in axial myopia
title_full	Altered spatial summation optimizes visual function in axial myopia
title_fullStr	Altered spatial summation optimizes visual function in axial myopia
title_full_unstemmed	Altered spatial summation optimizes visual function in axial myopia
title_sort	altered spatial summation optimizes visual function in axial myopia
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4923422294014fbfa141208938a517ff
work_keys_str_mv	AT victoriastapley alteredspatialsummationoptimizesvisualfunctioninaxialmyopia AT rogersanderson alteredspatialsummationoptimizesvisualfunctioninaxialmyopia AT kathrynjsaunders alteredspatialsummationoptimizesvisualfunctioninaxialmyopia AT padraigjmulholland alteredspatialsummationoptimizesvisualfunctioninaxialmyopia
_version_	1718383988044726272

Altered spatial summation optimizes visual function in axial myopia

Ejemplares similares