Heritability of distichiasis in Havanese dogs in Norway

Plain English summary: prevalence and heritability of distichiasis in a population of Havanese Dogs Distichiasis is an eye condition, characterized by misplaced eyelashes, that is frequently seen in dogs. Some dog breeds appear to be more at risk than others. The degree of clinical signs in affected...

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Autores principales:	Kim K. L. Bellamy, Frode Lingaas, Per Madsen
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Distichiasis Havanese Heritability Prevalence Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/492b9b4a84f442d3910e87bd13c557d8
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spelling	oai:doaj.org-article:492b9b4a84f442d3910e87bd13c557d82021-11-21T12:03:16ZHeritability of distichiasis in Havanese dogs in Norway10.1186/s40575-021-00110-52662-9380https://doaj.org/article/492b9b4a84f442d3910e87bd13c557d82021-11-01T00:00:00Zhttps://doi.org/10.1186/s40575-021-00110-5https://doaj.org/toc/2662-9380Plain English summary: prevalence and heritability of distichiasis in a population of Havanese Dogs Distichiasis is an eye condition, characterized by misplaced eyelashes, that is frequently seen in dogs. Some dog breeds appear to be more at risk than others. The degree of clinical signs in affected dogs varies a lot. Many mild cases appear to be completely asymptomatic, while others suffer pain and damage to the eye, which necessitates removal of the hairs. In this study, we investigate both how common distichiasis is in the Havanese dog breed and estimate the degree of genetic influence on the trait. We find that 14.5% of eye screened Havanese, registered in the Norwegian Kennel Club, are affected with distichiasis. Most cases are graded “mild”. There is no significant difference in how many males and females are affected. We find high heritability estimates of distichiasis in Havanese (≈0.28 calculated by linear models and 0.59-0.72 calculated by Bayesian threshold models), showing a high genetic influence on the trait. The high estimated heritability mean that it should be possible to reduce the prevalence of the condition, and contribute to improved animal welfare, though systematic breeding. We recommend that all Havanese are eye screened prior to breeding, to control the prevalence of distichiasis, as well as other eye conditions that are relevant in the breed, like cataracts. Dogs with severe distichiasis or ectopic cilia should not be bred. Dogs with mild or moderate distichiasis may be bred to an unaffected partner.Kim K. L. BellamyFrode LingaasPer MadsenBMCarticleDistichiasisHavaneseHeritabilityPrevalenceVeterinary medicineSF600-1100ENCanine Medicine and Genetics, Vol 8, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Distichiasis Havanese Heritability Prevalence Veterinary medicine SF600-1100
spellingShingle	Distichiasis Havanese Heritability Prevalence Veterinary medicine SF600-1100 Kim K. L. Bellamy Frode Lingaas Per Madsen Heritability of distichiasis in Havanese dogs in Norway
description	Plain English summary: prevalence and heritability of distichiasis in a population of Havanese Dogs Distichiasis is an eye condition, characterized by misplaced eyelashes, that is frequently seen in dogs. Some dog breeds appear to be more at risk than others. The degree of clinical signs in affected dogs varies a lot. Many mild cases appear to be completely asymptomatic, while others suffer pain and damage to the eye, which necessitates removal of the hairs. In this study, we investigate both how common distichiasis is in the Havanese dog breed and estimate the degree of genetic influence on the trait. We find that 14.5% of eye screened Havanese, registered in the Norwegian Kennel Club, are affected with distichiasis. Most cases are graded “mild”. There is no significant difference in how many males and females are affected. We find high heritability estimates of distichiasis in Havanese (≈0.28 calculated by linear models and 0.59-0.72 calculated by Bayesian threshold models), showing a high genetic influence on the trait. The high estimated heritability mean that it should be possible to reduce the prevalence of the condition, and contribute to improved animal welfare, though systematic breeding. We recommend that all Havanese are eye screened prior to breeding, to control the prevalence of distichiasis, as well as other eye conditions that are relevant in the breed, like cataracts. Dogs with severe distichiasis or ectopic cilia should not be bred. Dogs with mild or moderate distichiasis may be bred to an unaffected partner.
format	article
author	Kim K. L. Bellamy Frode Lingaas Per Madsen
author_facet	Kim K. L. Bellamy Frode Lingaas Per Madsen
author_sort	Kim K. L. Bellamy
title	Heritability of distichiasis in Havanese dogs in Norway
title_short	Heritability of distichiasis in Havanese dogs in Norway
title_full	Heritability of distichiasis in Havanese dogs in Norway
title_fullStr	Heritability of distichiasis in Havanese dogs in Norway
title_full_unstemmed	Heritability of distichiasis in Havanese dogs in Norway
title_sort	heritability of distichiasis in havanese dogs in norway
publisher	BMC
publishDate	2021
url	https://doaj.org/article/492b9b4a84f442d3910e87bd13c557d8
work_keys_str_mv	AT kimklbellamy heritabilityofdistichiasisinhavanesedogsinnorway AT frodelingaas heritabilityofdistichiasisinhavanesedogsinnorway AT permadsen heritabilityofdistichiasisinhavanesedogsinnorway
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Heritability of distichiasis in Havanese dogs in Norway

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