Nonsteroidal Anti-inflammatory Drugs Alter the Microbiota and Exacerbate <italic toggle="yes">Clostridium difficile</italic> Colitis while Dysregulating the Inflammatory Response

Nonsteroidal Anti-inflammatory Drugs Alter the Microbiota and Exacerbate <italic toggle="yes">Clostridium difficile</italic> Colitis while Dysregulating the Inflammatory Response

ABSTRACT Clostridium difficile infection (CDI) is a major public health threat worldwide. The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with enhanced susceptibility to and severity of CDI; however, the mechanisms driving this phenomenon have not been elucidated. NSAIDs alter...

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Autores principales: Damian Maseda, Joseph P. Zackular, Bruno Trindade, Leslie Kirk, Jennifer Lising Roxas, Lisa M. Rogers, Mary K. Washington, Liping Du, Tatsuki Koyama, V. K. Viswanathan, Gayatri Vedantam, Patrick D. Schloss, Leslie J. Crofford, Eric P. Skaar, David M. Aronoff
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
Materias:
Clostridium difficile
colitis
gut inflammation
immune dysfunction
immune response
inflammation
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/492be4d6751442bda2d9d927ff64c839
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