Time to Immunologic Recovery and Its Determinant Factors Among Adult HIV Patients Who Initiated Antiretroviral Treatment at Hiwot Fana Specialized University Hospital, Harar, Ethiopia

Fekade Demeke Bayou,1 Shambel Nigussie Amare2 1Department of Epidemiology, College of Medicine and Health Sciences, Jigjiga University, Jigjiga, Ethiopia; 2Department of Clinical Pharmacy, School of pharmacy, College of Health and Medical Science, Haramaya University, Harar, EthiopiaCorrespondence:...

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Autores principales:	Demeke Bayou F, Nigussie Amare S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	time to immunologic recovery cd4 count harer ethiopia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/492db266aa65443090c8e19ec1480f6c
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spelling	oai:doaj.org-article:492db266aa65443090c8e19ec1480f6c2021-12-02T19:17:36ZTime to Immunologic Recovery and Its Determinant Factors Among Adult HIV Patients Who Initiated Antiretroviral Treatment at Hiwot Fana Specialized University Hospital, Harar, Ethiopia1179-1373https://doaj.org/article/492db266aa65443090c8e19ec1480f6c2021-12-01T00:00:00Zhttps://www.dovepress.com/time-to-immunologic-recovery-and-its-determinant-factors-among-adult-h-peer-reviewed-fulltext-article-HIVhttps://doaj.org/toc/1179-1373Fekade Demeke Bayou,1 Shambel Nigussie Amare2 1Department of Epidemiology, College of Medicine and Health Sciences, Jigjiga University, Jigjiga, Ethiopia; 2Department of Clinical Pharmacy, School of pharmacy, College of Health and Medical Science, Haramaya University, Harar, EthiopiaCorrespondence: Fekade Demeke Bayou Email fekadedemeke12@gmail.comObjective: To determine the time to immunologic recovery and its determinant factors among adult HIV patients who initiated antiretroviral treatment at Hiwot Fana Specialized University Hospital from February, 2018 to January, 2020.Methods: A facility-based retrospective cohort study was conducted among 301 adult HIV patients who initiated antiretroviral treatment from February, 2018 to January, 2020. Five trained nurses collected the data using data abstraction checklists. The collected data were entered into the computer using EpiData version 3.1 and then exported to Statistical Package for Social Sciences (SPSS) version 25. The median survival time to immunologic recovery was described using Kaplan–Meier (KM) estimator. Cox proportional hazards regression model was used to identify the potential determinant factors of the time to immunologic recovery. An adjusted hazard ratio (AHR) with its 95% confidence interval (CI) and p-values < 0.05 were used to determine the strength and significance of associations between variables.Results: In this study, the overall median time required to reach normal CD4 count was 11 months [95% CI = (9.50, 12.51)]. Baseline functional status, ambulatory [AHR=1.383, 95% CI (1.05, 1.83)], bedridden [AHR=1.712 (1.11, 2.64)], first-line treatment classes (TDF/3TC/DTG) [AHR= 1.63, 95% CI (1.21, 2.18)], and baseline CD4 count > 350 cells/mm3 [AHR=1.65, 95% CI (1.11, 2.45)] were significantly associated with the time to immunologic recovery.Conclusion: The median time to immunologic recovery was relatively shorter. Baseline functional status (ambulatory and bedridden), baseline CD4 count, and first-line treatment class were significant predictors of time to immunologic recovery. HIV patients with working functional status should be given the necessary attention. Utilization of dolutegravir-based regimens should be encouraged to attain a normal CD4 count earlier.Keywords: time to immunologic recovery, CD4 count, Harer, EthiopiaDemeke Bayou FNigussie Amare SDove Medical Pressarticletime to immunologic recoverycd4 countharerethiopiaImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 13, Pp 1009-1014 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	time to immunologic recovery cd4 count harer ethiopia Immunologic diseases. Allergy RC581-607
spellingShingle	time to immunologic recovery cd4 count harer ethiopia Immunologic diseases. Allergy RC581-607 Demeke Bayou F Nigussie Amare S Time to Immunologic Recovery and Its Determinant Factors Among Adult HIV Patients Who Initiated Antiretroviral Treatment at Hiwot Fana Specialized University Hospital, Harar, Ethiopia
description	Fekade Demeke Bayou,1 Shambel Nigussie Amare2 1Department of Epidemiology, College of Medicine and Health Sciences, Jigjiga University, Jigjiga, Ethiopia; 2Department of Clinical Pharmacy, School of pharmacy, College of Health and Medical Science, Haramaya University, Harar, EthiopiaCorrespondence: Fekade Demeke Bayou Email fekadedemeke12@gmail.comObjective: To determine the time to immunologic recovery and its determinant factors among adult HIV patients who initiated antiretroviral treatment at Hiwot Fana Specialized University Hospital from February, 2018 to January, 2020.Methods: A facility-based retrospective cohort study was conducted among 301 adult HIV patients who initiated antiretroviral treatment from February, 2018 to January, 2020. Five trained nurses collected the data using data abstraction checklists. The collected data were entered into the computer using EpiData version 3.1 and then exported to Statistical Package for Social Sciences (SPSS) version 25. The median survival time to immunologic recovery was described using Kaplan–Meier (KM) estimator. Cox proportional hazards regression model was used to identify the potential determinant factors of the time to immunologic recovery. An adjusted hazard ratio (AHR) with its 95% confidence interval (CI) and p-values < 0.05 were used to determine the strength and significance of associations between variables.Results: In this study, the overall median time required to reach normal CD4 count was 11 months [95% CI = (9.50, 12.51)]. Baseline functional status, ambulatory [AHR=1.383, 95% CI (1.05, 1.83)], bedridden [AHR=1.712 (1.11, 2.64)], first-line treatment classes (TDF/3TC/DTG) [AHR= 1.63, 95% CI (1.21, 2.18)], and baseline CD4 count > 350 cells/mm3 [AHR=1.65, 95% CI (1.11, 2.45)] were significantly associated with the time to immunologic recovery.Conclusion: The median time to immunologic recovery was relatively shorter. Baseline functional status (ambulatory and bedridden), baseline CD4 count, and first-line treatment class were significant predictors of time to immunologic recovery. HIV patients with working functional status should be given the necessary attention. Utilization of dolutegravir-based regimens should be encouraged to attain a normal CD4 count earlier.Keywords: time to immunologic recovery, CD4 count, Harer, Ethiopia
format	article
author	Demeke Bayou F Nigussie Amare S
author_facet	Demeke Bayou F Nigussie Amare S
author_sort	Demeke Bayou F
title	Time to Immunologic Recovery and Its Determinant Factors Among Adult HIV Patients Who Initiated Antiretroviral Treatment at Hiwot Fana Specialized University Hospital, Harar, Ethiopia
title_short	Time to Immunologic Recovery and Its Determinant Factors Among Adult HIV Patients Who Initiated Antiretroviral Treatment at Hiwot Fana Specialized University Hospital, Harar, Ethiopia
title_full	Time to Immunologic Recovery and Its Determinant Factors Among Adult HIV Patients Who Initiated Antiretroviral Treatment at Hiwot Fana Specialized University Hospital, Harar, Ethiopia
title_fullStr	Time to Immunologic Recovery and Its Determinant Factors Among Adult HIV Patients Who Initiated Antiretroviral Treatment at Hiwot Fana Specialized University Hospital, Harar, Ethiopia
title_full_unstemmed	Time to Immunologic Recovery and Its Determinant Factors Among Adult HIV Patients Who Initiated Antiretroviral Treatment at Hiwot Fana Specialized University Hospital, Harar, Ethiopia
title_sort	time to immunologic recovery and its determinant factors among adult hiv patients who initiated antiretroviral treatment at hiwot fana specialized university hospital, harar, ethiopia
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/492db266aa65443090c8e19ec1480f6c
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Time to Immunologic Recovery and Its Determinant Factors Among Adult HIV Patients Who Initiated Antiretroviral Treatment at Hiwot Fana Specialized University Hospital, Harar, Ethiopia

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