Mixed Cryoglobulinaemia Vasculitis Treated with Obinutuzumab in a Patient Allergic to Rituximab

Cryoglobulinaemia is defined as the presence of cryoglobulins in the serum, which are immunoglobulins that reversibly precipitate and form a gel when the temperature is <37ºC. Autoimmune diseases such as Sjogren’s syndrome, systemic lupus erythematosus and rheumatoid arthritis could be associated...

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Autores principales:	Margarida Gaudencio, Catarina Parente, Ana Catarina Lameiras, António Marinho
Formato:	article
Lenguaje:	EN
Publicado:	SMC MEDIA SRL 2021
Materias:	mixed cryoglobulinaemia overlap syndrome autoimmune diseases. remission internal carotid vasculitis obinutuzumab Medicine R
Acceso en línea:	https://doaj.org/article/493992edc68b4da5a380c8b7923b82d3
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spelling	oai:doaj.org-article:493992edc68b4da5a380c8b7923b82d32021-11-23T16:02:20ZMixed Cryoglobulinaemia Vasculitis Treated with Obinutuzumab in a Patient Allergic to Rituximab2284-259410.12890/2021_003019https://doaj.org/article/493992edc68b4da5a380c8b7923b82d32021-11-01T00:00:00Zhttps://www.ejcrim.com/index.php/EJCRIM/article/view/3019https://doaj.org/toc/2284-2594Cryoglobulinaemia is defined as the presence of cryoglobulins in the serum, which are immunoglobulins that reversibly precipitate and form a gel when the temperature is <37ºC. Autoimmune diseases such as Sjogren’s syndrome, systemic lupus erythematosus and rheumatoid arthritis could be associated with mixed cryoglobulinaemia vasculitis (MCV). The treatment of MCV generally consists of glucocorticoids, cytotoxic agents such as cyclophosphamide, plasmapheresis or anti-CD20 monoclonal antibodies including rituximab. Here, we present a case of a 60-year-old woman who developed type II MCV in the context of overlap autoimmune disease and who has been treated with a new anti-CD20 agent, obinutuzumab.Margarida GaudencioCatarina ParenteAna Catarina LameirasAntónio MarinhoSMC MEDIA SRLarticlemixed cryoglobulinaemiaoverlap syndromeautoimmune diseases.remissioninternal carotid vasculitisobinutuzumabMedicineRENEuropean Journal of Case Reports in Internal Medicine (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mixed cryoglobulinaemia overlap syndrome autoimmune diseases. remission internal carotid vasculitis obinutuzumab Medicine R
spellingShingle	mixed cryoglobulinaemia overlap syndrome autoimmune diseases. remission internal carotid vasculitis obinutuzumab Medicine R Margarida Gaudencio Catarina Parente Ana Catarina Lameiras António Marinho Mixed Cryoglobulinaemia Vasculitis Treated with Obinutuzumab in a Patient Allergic to Rituximab
description	Cryoglobulinaemia is defined as the presence of cryoglobulins in the serum, which are immunoglobulins that reversibly precipitate and form a gel when the temperature is <37ºC. Autoimmune diseases such as Sjogren’s syndrome, systemic lupus erythematosus and rheumatoid arthritis could be associated with mixed cryoglobulinaemia vasculitis (MCV). The treatment of MCV generally consists of glucocorticoids, cytotoxic agents such as cyclophosphamide, plasmapheresis or anti-CD20 monoclonal antibodies including rituximab. Here, we present a case of a 60-year-old woman who developed type II MCV in the context of overlap autoimmune disease and who has been treated with a new anti-CD20 agent, obinutuzumab.
format	article
author	Margarida Gaudencio Catarina Parente Ana Catarina Lameiras António Marinho
author_facet	Margarida Gaudencio Catarina Parente Ana Catarina Lameiras António Marinho
author_sort	Margarida Gaudencio
title	Mixed Cryoglobulinaemia Vasculitis Treated with Obinutuzumab in a Patient Allergic to Rituximab
title_short	Mixed Cryoglobulinaemia Vasculitis Treated with Obinutuzumab in a Patient Allergic to Rituximab
title_full	Mixed Cryoglobulinaemia Vasculitis Treated with Obinutuzumab in a Patient Allergic to Rituximab
title_fullStr	Mixed Cryoglobulinaemia Vasculitis Treated with Obinutuzumab in a Patient Allergic to Rituximab
title_full_unstemmed	Mixed Cryoglobulinaemia Vasculitis Treated with Obinutuzumab in a Patient Allergic to Rituximab
title_sort	mixed cryoglobulinaemia vasculitis treated with obinutuzumab in a patient allergic to rituximab
publisher	SMC MEDIA SRL
publishDate	2021
url	https://doaj.org/article/493992edc68b4da5a380c8b7923b82d3
work_keys_str_mv	AT margaridagaudencio mixedcryoglobulinaemiavasculitistreatedwithobinutuzumabinapatientallergictorituximab AT catarinaparente mixedcryoglobulinaemiavasculitistreatedwithobinutuzumabinapatientallergictorituximab AT anacatarinalameiras mixedcryoglobulinaemiavasculitistreatedwithobinutuzumabinapatientallergictorituximab AT antoniomarinho mixedcryoglobulinaemiavasculitistreatedwithobinutuzumabinapatientallergictorituximab
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Mixed Cryoglobulinaemia Vasculitis Treated with Obinutuzumab in a Patient Allergic to Rituximab

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