Genetics of body fat mass and related traits in a pig population selected for leanness

Abstract Obesity is characterized as the excessive accumulation of body fat and has a complex genetic foundation in humans including monogenic high-risk mutations and polygenic contributions. Domestic pigs represent a valuable model on an obesity-promoting high-caloric diet while constantly evaluate...

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Autores principales:	Henry Reyer, Patrick F. Varley, Eduard Murani, Siriluck Ponsuksili, Klaus Wimmers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/493b6baa931e4623a621aceeacfc35a1
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spelling	oai:doaj.org-article:493b6baa931e4623a621aceeacfc35a12021-12-02T16:06:05ZGenetics of body fat mass and related traits in a pig population selected for leanness10.1038/s41598-017-08961-42045-2322https://doaj.org/article/493b6baa931e4623a621aceeacfc35a12017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08961-4https://doaj.org/toc/2045-2322Abstract Obesity is characterized as the excessive accumulation of body fat and has a complex genetic foundation in humans including monogenic high-risk mutations and polygenic contributions. Domestic pigs represent a valuable model on an obesity-promoting high-caloric diet while constantly evaluated for body characteristics. As such, we investigated the genetics of obesity-related traits, comprising subcutaneous fat thickness, lean mass percentage, and growth rate, in a pig population. We conducted genome-wide association analyses using an integrative approach of single-marker regression models and multi-marker Bayesian analyses. Thus, we identified 30 genomic regions distributed over 14 different chromosomes contributing to the variation in obesity-related traits. In these regions, we validated the association of four candidate genes that are functionally connected to the regulation of appetite, processes of adipogenesis, and extracellular matrix formation. Our findings revealed fundamental genetic factors which deserves closer attention regarding their roles in the etiology of obesity.Henry ReyerPatrick F. VarleyEduard MuraniSiriluck PonsuksiliKlaus WimmersNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Henry Reyer Patrick F. Varley Eduard Murani Siriluck Ponsuksili Klaus Wimmers Genetics of body fat mass and related traits in a pig population selected for leanness
description	Abstract Obesity is characterized as the excessive accumulation of body fat and has a complex genetic foundation in humans including monogenic high-risk mutations and polygenic contributions. Domestic pigs represent a valuable model on an obesity-promoting high-caloric diet while constantly evaluated for body characteristics. As such, we investigated the genetics of obesity-related traits, comprising subcutaneous fat thickness, lean mass percentage, and growth rate, in a pig population. We conducted genome-wide association analyses using an integrative approach of single-marker regression models and multi-marker Bayesian analyses. Thus, we identified 30 genomic regions distributed over 14 different chromosomes contributing to the variation in obesity-related traits. In these regions, we validated the association of four candidate genes that are functionally connected to the regulation of appetite, processes of adipogenesis, and extracellular matrix formation. Our findings revealed fundamental genetic factors which deserves closer attention regarding their roles in the etiology of obesity.
format	article
author	Henry Reyer Patrick F. Varley Eduard Murani Siriluck Ponsuksili Klaus Wimmers
author_facet	Henry Reyer Patrick F. Varley Eduard Murani Siriluck Ponsuksili Klaus Wimmers
author_sort	Henry Reyer
title	Genetics of body fat mass and related traits in a pig population selected for leanness
title_short	Genetics of body fat mass and related traits in a pig population selected for leanness
title_full	Genetics of body fat mass and related traits in a pig population selected for leanness
title_fullStr	Genetics of body fat mass and related traits in a pig population selected for leanness
title_full_unstemmed	Genetics of body fat mass and related traits in a pig population selected for leanness
title_sort	genetics of body fat mass and related traits in a pig population selected for leanness
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/493b6baa931e4623a621aceeacfc35a1
work_keys_str_mv	AT henryreyer geneticsofbodyfatmassandrelatedtraitsinapigpopulationselectedforleanness AT patrickfvarley geneticsofbodyfatmassandrelatedtraitsinapigpopulationselectedforleanness AT eduardmurani geneticsofbodyfatmassandrelatedtraitsinapigpopulationselectedforleanness AT siriluckponsuksili geneticsofbodyfatmassandrelatedtraitsinapigpopulationselectedforleanness AT klauswimmers geneticsofbodyfatmassandrelatedtraitsinapigpopulationselectedforleanness
_version_	1718385085420404736

Genetics of body fat mass and related traits in a pig population selected for leanness

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