THE ROLE OF INTERLEUKIN 1β GENE POLYMORPHISM IN DEVELOPMENT OF PREDOMINANTY SENSORY CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY

The aim of the present study was a search for associations between the polymorphic allelic variants 3954 C>T (rs1143644) and -511C>T (rs16944) of IL1B gene in the patients with sensory predominant chronic inflammatory demyelinating polyneuropathies (SP-CIDP) from Krasnoyarsk Region and...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	T. E. Popova, N. A. Shnayder, M. M. Petrova, A. A. Tappakhov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2019
Materias:	sp-cidp il-1β gene il1b single nucleotide polymorphisms genetic association analysis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/493fa995eac04ef083030db584bb7a26
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:493fa995eac04ef083030db584bb7a26
record_format	dspace
spelling	oai:doaj.org-article:493fa995eac04ef083030db584bb7a262021-11-18T08:03:48ZTHE ROLE OF INTERLEUKIN 1β GENE POLYMORPHISM IN DEVELOPMENT OF PREDOMINANTY SENSORY CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY1563-06252313-741X10.15789/1563-0625-2019-1-141-148https://doaj.org/article/493fa995eac04ef083030db584bb7a262019-01-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1708https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe aim of the present study was a search for associations between the polymorphic allelic variants 3954 C>T (rs1143644) and -511C>T (rs16944) of IL1B gene in the patients with sensory predominant chronic inflammatory demyelinating polyneuropathies (SP-CIDP) from Krasnoyarsk Region and the Sakha (Yakutia) Republic. A total of 95 people were examined, having been divided into 2 groups according to their residence. The first group consisted of 42 patients living in the Sakha (Yakutia) Republic. The second group included 53 patients living in the Krasnoyarsk Region. It was revealed that the carriers of homozygous CC genotype in the 3954C>T locus were more often detected in patients from the Sakha (Yakutia) Republic, and the carriage of TT genotype is found exclusively in the patients from Krasnoyarsk Region. When comparing the different genotype frequencies in the -511CT locus, we did not reveal any statistically significant differences between the two groups of patients. Presence of the CC genotype of the 3954C>T locus was associated with a significantly increased risk of disease in the patients from Sakha (Yakutia) Republic, while carrying CT and TT genotypes at the locus 3954C>T and the TT genotype at the locus -511C>T, is associated with increased risk disorder among patients of the Krasnoyarsk Region. The frequency of carriage of various genotypes in the 3954C>T and -511C>T loci of the IL1B gene was prevalent among the patients from the Sakha (Yakutia) Republic, the association of genotypes of CC/CT prevailed in patients from the Krasnoyarsk Region (p = 0.005), as well as prevalence of CC/CC and CC/CT (p = 0.023). However, there was no statistically significant difference in occurrence of individual genotypes between the two study groups. When analyzing the carrier frequency of high-producing alleles of 3954C and -511C in patients with SP-CIDP, it was shown that they were significantly more common among patients from the Sakha (Yakutia) Republic and patients from the Krasnoyarsk Region than the low-producing 3954T and -511T alleles. Moreover, the 3954C allele was more often found in the Yakut group (p = 0.001), and in the -511C allele for the Krasnoyarsk group of patients (p = 0.05). The presence of 3954C and -511C alleles increases the risk of SP-CIDP development in patients from the Sakha (Yakutia) Republic, as well as carriage of 3954T allele in patients from the Krasnoyarsk Region.T. E. PopovaN. A. ShnayderM. M. PetrovaA. A. TappakhovSPb RAACIarticlesp-cidpil-1βgene il1bsingle nucleotide polymorphismsgeneticassociation analysisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 1, Pp 141-148 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	sp-cidp il-1β gene il1b single nucleotide polymorphisms genetic association analysis Immunologic diseases. Allergy RC581-607
spellingShingle	sp-cidp il-1β gene il1b single nucleotide polymorphisms genetic association analysis Immunologic diseases. Allergy RC581-607 T. E. Popova N. A. Shnayder M. M. Petrova A. A. Tappakhov THE ROLE OF INTERLEUKIN 1β GENE POLYMORPHISM IN DEVELOPMENT OF PREDOMINANTY SENSORY CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY
description	The aim of the present study was a search for associations between the polymorphic allelic variants 3954 C>T (rs1143644) and -511C>T (rs16944) of IL1B gene in the patients with sensory predominant chronic inflammatory demyelinating polyneuropathies (SP-CIDP) from Krasnoyarsk Region and the Sakha (Yakutia) Republic. A total of 95 people were examined, having been divided into 2 groups according to their residence. The first group consisted of 42 patients living in the Sakha (Yakutia) Republic. The second group included 53 patients living in the Krasnoyarsk Region. It was revealed that the carriers of homozygous CC genotype in the 3954C>T locus were more often detected in patients from the Sakha (Yakutia) Republic, and the carriage of TT genotype is found exclusively in the patients from Krasnoyarsk Region. When comparing the different genotype frequencies in the -511CT locus, we did not reveal any statistically significant differences between the two groups of patients. Presence of the CC genotype of the 3954C>T locus was associated with a significantly increased risk of disease in the patients from Sakha (Yakutia) Republic, while carrying CT and TT genotypes at the locus 3954C>T and the TT genotype at the locus -511C>T, is associated with increased risk disorder among patients of the Krasnoyarsk Region. The frequency of carriage of various genotypes in the 3954C>T and -511C>T loci of the IL1B gene was prevalent among the patients from the Sakha (Yakutia) Republic, the association of genotypes of CC/CT prevailed in patients from the Krasnoyarsk Region (p = 0.005), as well as prevalence of CC/CC and CC/CT (p = 0.023). However, there was no statistically significant difference in occurrence of individual genotypes between the two study groups. When analyzing the carrier frequency of high-producing alleles of 3954C and -511C in patients with SP-CIDP, it was shown that they were significantly more common among patients from the Sakha (Yakutia) Republic and patients from the Krasnoyarsk Region than the low-producing 3954T and -511T alleles. Moreover, the 3954C allele was more often found in the Yakut group (p = 0.001), and in the -511C allele for the Krasnoyarsk group of patients (p = 0.05). The presence of 3954C and -511C alleles increases the risk of SP-CIDP development in patients from the Sakha (Yakutia) Republic, as well as carriage of 3954T allele in patients from the Krasnoyarsk Region.
format	article
author	T. E. Popova N. A. Shnayder M. M. Petrova A. A. Tappakhov
author_facet	T. E. Popova N. A. Shnayder M. M. Petrova A. A. Tappakhov
author_sort	T. E. Popova
title	THE ROLE OF INTERLEUKIN 1β GENE POLYMORPHISM IN DEVELOPMENT OF PREDOMINANTY SENSORY CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY
title_short	THE ROLE OF INTERLEUKIN 1β GENE POLYMORPHISM IN DEVELOPMENT OF PREDOMINANTY SENSORY CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY
title_full	THE ROLE OF INTERLEUKIN 1β GENE POLYMORPHISM IN DEVELOPMENT OF PREDOMINANTY SENSORY CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY
title_fullStr	THE ROLE OF INTERLEUKIN 1β GENE POLYMORPHISM IN DEVELOPMENT OF PREDOMINANTY SENSORY CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY
title_full_unstemmed	THE ROLE OF INTERLEUKIN 1β GENE POLYMORPHISM IN DEVELOPMENT OF PREDOMINANTY SENSORY CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY
title_sort	role of interleukin 1β gene polymorphism in development of predominanty sensory chronic inflammatory demyelinating polyneuropathy
publisher	SPb RAACI
publishDate	2019
url	https://doaj.org/article/493fa995eac04ef083030db584bb7a26
work_keys_str_mv	AT tepopova theroleofinterleukin1bgenepolymorphismindevelopmentofpredominantysensorychronicinflammatorydemyelinatingpolyneuropathy AT nashnayder theroleofinterleukin1bgenepolymorphismindevelopmentofpredominantysensorychronicinflammatorydemyelinatingpolyneuropathy AT mmpetrova theroleofinterleukin1bgenepolymorphismindevelopmentofpredominantysensorychronicinflammatorydemyelinatingpolyneuropathy AT aatappakhov theroleofinterleukin1bgenepolymorphismindevelopmentofpredominantysensorychronicinflammatorydemyelinatingpolyneuropathy AT tepopova roleofinterleukin1bgenepolymorphismindevelopmentofpredominantysensorychronicinflammatorydemyelinatingpolyneuropathy AT nashnayder roleofinterleukin1bgenepolymorphismindevelopmentofpredominantysensorychronicinflammatorydemyelinatingpolyneuropathy AT mmpetrova roleofinterleukin1bgenepolymorphismindevelopmentofpredominantysensorychronicinflammatorydemyelinatingpolyneuropathy AT aatappakhov roleofinterleukin1bgenepolymorphismindevelopmentofpredominantysensorychronicinflammatorydemyelinatingpolyneuropathy
_version_	1718422345558786048

THE ROLE OF INTERLEUKIN 1β GENE POLYMORPHISM IN DEVELOPMENT OF PREDOMINANTY SENSORY CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY

Ejemplares similares