The lateral parabrachial nucleus, but not the thalamus, mediates thermosensory pathways for behavioural thermoregulation

Abstract Thermoregulatory behaviour, such as migration to a comfortable thermal environment, is a representative innate animal behaviour and facilitates effective autonomic regulation of body temperature with a reduced cost of resources. Here we determine the central thermosensory ascending pathway...

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Autores principales:	Takaki Yahiro, Naoya Kataoka, Yoshiko Nakamura, Kazuhiro Nakamura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/49403ffc9adf4f439dd7b91af9cf27e5
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spelling	oai:doaj.org-article:49403ffc9adf4f439dd7b91af9cf27e52021-12-02T12:32:54ZThe lateral parabrachial nucleus, but not the thalamus, mediates thermosensory pathways for behavioural thermoregulation10.1038/s41598-017-05327-82045-2322https://doaj.org/article/49403ffc9adf4f439dd7b91af9cf27e52017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05327-8https://doaj.org/toc/2045-2322Abstract Thermoregulatory behaviour, such as migration to a comfortable thermal environment, is a representative innate animal behaviour and facilitates effective autonomic regulation of body temperature with a reduced cost of resources. Here we determine the central thermosensory ascending pathway that transmits information on environmental temperature from cutaneous thermoreceptors to elicit thermoregulatory behaviour. To examine the contribution of the spinothalamocortical pathway, which is known to mediate thermosensory transmission for perception of skin temperature, we lesioned thalamic regions mediating this pathway in rats. Thalamic-lesioned rats showed compromised electroencephalographic responses in the primary somatosensory cortex to changes in skin temperature, indicating functional ablation of the spinothalamocortical pathway. However, these lesioned rats subjected to a two-floor innocuous thermal plate preference test displayed intact heat- and cold-avoidance thermoregulatory behaviours. We then examined the involvement of the lateral parabrachial nucleus (LPB), which mediates cutaneous thermosensory signaling to the thermoregulatory center for autonomic thermoregulation. Inactivation of neurons in the LPB eliminated both heat- and cold-avoidance thermoregulatory behaviours and ablated heat defense. These results demonstrate that the LPB, but not the thalamus, mediates the cutaneous thermosensory neural signaling required for behavioural thermoregulation, contributing to understanding of the central circuit that generates thermal comfort and discomfort underlying thermoregulatory behaviours.Takaki YahiroNaoya KataokaYoshiko NakamuraKazuhiro NakamuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takaki Yahiro Naoya Kataoka Yoshiko Nakamura Kazuhiro Nakamura The lateral parabrachial nucleus, but not the thalamus, mediates thermosensory pathways for behavioural thermoregulation
description	Abstract Thermoregulatory behaviour, such as migration to a comfortable thermal environment, is a representative innate animal behaviour and facilitates effective autonomic regulation of body temperature with a reduced cost of resources. Here we determine the central thermosensory ascending pathway that transmits information on environmental temperature from cutaneous thermoreceptors to elicit thermoregulatory behaviour. To examine the contribution of the spinothalamocortical pathway, which is known to mediate thermosensory transmission for perception of skin temperature, we lesioned thalamic regions mediating this pathway in rats. Thalamic-lesioned rats showed compromised electroencephalographic responses in the primary somatosensory cortex to changes in skin temperature, indicating functional ablation of the spinothalamocortical pathway. However, these lesioned rats subjected to a two-floor innocuous thermal plate preference test displayed intact heat- and cold-avoidance thermoregulatory behaviours. We then examined the involvement of the lateral parabrachial nucleus (LPB), which mediates cutaneous thermosensory signaling to the thermoregulatory center for autonomic thermoregulation. Inactivation of neurons in the LPB eliminated both heat- and cold-avoidance thermoregulatory behaviours and ablated heat defense. These results demonstrate that the LPB, but not the thalamus, mediates the cutaneous thermosensory neural signaling required for behavioural thermoregulation, contributing to understanding of the central circuit that generates thermal comfort and discomfort underlying thermoregulatory behaviours.
format	article
author	Takaki Yahiro Naoya Kataoka Yoshiko Nakamura Kazuhiro Nakamura
author_facet	Takaki Yahiro Naoya Kataoka Yoshiko Nakamura Kazuhiro Nakamura
author_sort	Takaki Yahiro
title	The lateral parabrachial nucleus, but not the thalamus, mediates thermosensory pathways for behavioural thermoregulation
title_short	The lateral parabrachial nucleus, but not the thalamus, mediates thermosensory pathways for behavioural thermoregulation
title_full	The lateral parabrachial nucleus, but not the thalamus, mediates thermosensory pathways for behavioural thermoregulation
title_fullStr	The lateral parabrachial nucleus, but not the thalamus, mediates thermosensory pathways for behavioural thermoregulation
title_full_unstemmed	The lateral parabrachial nucleus, but not the thalamus, mediates thermosensory pathways for behavioural thermoregulation
title_sort	lateral parabrachial nucleus, but not the thalamus, mediates thermosensory pathways for behavioural thermoregulation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/49403ffc9adf4f439dd7b91af9cf27e5
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The lateral parabrachial nucleus, but not the thalamus, mediates thermosensory pathways for behavioural thermoregulation

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