High Incidence of Distant Metastasis Is Associated With Histopathological Subtype of Pediatric Papillary Thyroid Cancer - a Retrospective Analysis Based on SEER

ObjectiveChildren with papillary thyroid cancer (PTC) have a higher invasive rate and distant metastasis rate, but the mortality rate is lower with unknown reasons. The majority of PTC cases comprise classical papillary thyroid carcinoma (CPTC) and follicular variant papillary thyroid carcinoma (FVP...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xue Zeng, Zhihong Wang, Zhiqiang Gui, Jingzhe Xiang, Mengsu Cao, Wei Sun, Liang He, Wenwu Dong, Jiapeng Huang, Dalin Zhang, Chengzhou Lv, Ting Zhang, Liang Shao, Ping Zhang, Hao Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	papillary thyroid carcinoma (PCT) histopathological subtype distant metastasis pediatrics - children SEER FVPTC Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/494210e6c54845e8a707c5756ee4e6ed
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:494210e6c54845e8a707c5756ee4e6ed
record_format	dspace
spelling	oai:doaj.org-article:494210e6c54845e8a707c5756ee4e6ed2021-11-11T10:20:43ZHigh Incidence of Distant Metastasis Is Associated With Histopathological Subtype of Pediatric Papillary Thyroid Cancer - a Retrospective Analysis Based on SEER1664-239210.3389/fendo.2021.760901https://doaj.org/article/494210e6c54845e8a707c5756ee4e6ed2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.760901/fullhttps://doaj.org/toc/1664-2392ObjectiveChildren with papillary thyroid cancer (PTC) have a higher invasive rate and distant metastasis rate, but the mortality rate is lower with unknown reasons. The majority of PTC cases comprise classical papillary thyroid carcinoma (CPTC) and follicular variant papillary thyroid carcinoma (FVPTC). This study aimed to determine the relationship between histopathological subtype and rate of distant metastasis and investigate factors influencing distant metastasis in pediatric PTC.MethodsA total of 102,981 PTC patients were recruited from SEER registry, 2004-2015. Proportion of distant metastasis between children (≤18 years) and adults with different histopathological subtypes was compared by propensity score matching. The cut-off age for distant metastasis in children was calculated by receiver operating characteristic (ROC) curve, and the risk factors for distant metastasis in pediatric patients were analyzed by logistic regression models.ResultsAmong the 1,484 children and 101,497 adults included in the study, the incidence of CPTC patients with distant metastasis in children was higher than that in adults (p<0.001). The ROC curve was calculated, which yielded a cut-off age for distant metastasis in CPTC children as 16 years old. In CPTC, the proportion of young children (2-16 years) with distant metastasis was higher than that of adolescents (17-18 years) and adults (>18 years) (both p<0.001). While there was no such trend in FVPTC. In young children (2-16 years), the incidence of CPTC with distant metastasis was higher than FVPTC (p=0.006). There was no difference between the proportion of CPTC and FVPTC with distant metastasis in adolescents (17-18 years) and adults. Logistic regression models revealed that extrathyroidal extension, lymph node metastasis and CPTC histopathological subtype were risk factors for distant metastasis in young children aged 2 -16 years.ConclusionsIn CPTC, the incidence of distant metastasis in young children (2-16 years) was significantly higher than that in adolescents (17-18 years) and adults (>18 years). In patients with distant metastasis aged 2-16 years, the proportion of CPTC was higer than that of FVPTC. Extrathyroidal extension, lymph node metastasis, and CPTC histopathological subtype were risk factors for distant metastasis in young children aged 2-16 years.Xue ZengZhihong WangZhiqiang GuiJingzhe XiangMengsu CaoWei SunLiang HeWenwu DongJiapeng HuangDalin ZhangChengzhou LvTing ZhangLiang ShaoPing ZhangHao ZhangFrontiers Media S.A.articlepapillary thyroid carcinoma (PCT)histopathological subtypedistant metastasispediatrics - childrenSEERFVPTCDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	papillary thyroid carcinoma (PCT) histopathological subtype distant metastasis pediatrics - children SEER FVPTC Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	papillary thyroid carcinoma (PCT) histopathological subtype distant metastasis pediatrics - children SEER FVPTC Diseases of the endocrine glands. Clinical endocrinology RC648-665 Xue Zeng Zhihong Wang Zhiqiang Gui Jingzhe Xiang Mengsu Cao Wei Sun Liang He Wenwu Dong Jiapeng Huang Dalin Zhang Chengzhou Lv Ting Zhang Liang Shao Ping Zhang Hao Zhang High Incidence of Distant Metastasis Is Associated With Histopathological Subtype of Pediatric Papillary Thyroid Cancer - a Retrospective Analysis Based on SEER
description	ObjectiveChildren with papillary thyroid cancer (PTC) have a higher invasive rate and distant metastasis rate, but the mortality rate is lower with unknown reasons. The majority of PTC cases comprise classical papillary thyroid carcinoma (CPTC) and follicular variant papillary thyroid carcinoma (FVPTC). This study aimed to determine the relationship between histopathological subtype and rate of distant metastasis and investigate factors influencing distant metastasis in pediatric PTC.MethodsA total of 102,981 PTC patients were recruited from SEER registry, 2004-2015. Proportion of distant metastasis between children (≤18 years) and adults with different histopathological subtypes was compared by propensity score matching. The cut-off age for distant metastasis in children was calculated by receiver operating characteristic (ROC) curve, and the risk factors for distant metastasis in pediatric patients were analyzed by logistic regression models.ResultsAmong the 1,484 children and 101,497 adults included in the study, the incidence of CPTC patients with distant metastasis in children was higher than that in adults (p<0.001). The ROC curve was calculated, which yielded a cut-off age for distant metastasis in CPTC children as 16 years old. In CPTC, the proportion of young children (2-16 years) with distant metastasis was higher than that of adolescents (17-18 years) and adults (>18 years) (both p<0.001). While there was no such trend in FVPTC. In young children (2-16 years), the incidence of CPTC with distant metastasis was higher than FVPTC (p=0.006). There was no difference between the proportion of CPTC and FVPTC with distant metastasis in adolescents (17-18 years) and adults. Logistic regression models revealed that extrathyroidal extension, lymph node metastasis and CPTC histopathological subtype were risk factors for distant metastasis in young children aged 2 -16 years.ConclusionsIn CPTC, the incidence of distant metastasis in young children (2-16 years) was significantly higher than that in adolescents (17-18 years) and adults (>18 years). In patients with distant metastasis aged 2-16 years, the proportion of CPTC was higer than that of FVPTC. Extrathyroidal extension, lymph node metastasis, and CPTC histopathological subtype were risk factors for distant metastasis in young children aged 2-16 years.
format	article
author	Xue Zeng Zhihong Wang Zhiqiang Gui Jingzhe Xiang Mengsu Cao Wei Sun Liang He Wenwu Dong Jiapeng Huang Dalin Zhang Chengzhou Lv Ting Zhang Liang Shao Ping Zhang Hao Zhang
author_facet	Xue Zeng Zhihong Wang Zhiqiang Gui Jingzhe Xiang Mengsu Cao Wei Sun Liang He Wenwu Dong Jiapeng Huang Dalin Zhang Chengzhou Lv Ting Zhang Liang Shao Ping Zhang Hao Zhang
author_sort	Xue Zeng
title	High Incidence of Distant Metastasis Is Associated With Histopathological Subtype of Pediatric Papillary Thyroid Cancer - a Retrospective Analysis Based on SEER
title_short	High Incidence of Distant Metastasis Is Associated With Histopathological Subtype of Pediatric Papillary Thyroid Cancer - a Retrospective Analysis Based on SEER
title_full	High Incidence of Distant Metastasis Is Associated With Histopathological Subtype of Pediatric Papillary Thyroid Cancer - a Retrospective Analysis Based on SEER
title_fullStr	High Incidence of Distant Metastasis Is Associated With Histopathological Subtype of Pediatric Papillary Thyroid Cancer - a Retrospective Analysis Based on SEER
title_full_unstemmed	High Incidence of Distant Metastasis Is Associated With Histopathological Subtype of Pediatric Papillary Thyroid Cancer - a Retrospective Analysis Based on SEER
title_sort	high incidence of distant metastasis is associated with histopathological subtype of pediatric papillary thyroid cancer - a retrospective analysis based on seer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/494210e6c54845e8a707c5756ee4e6ed
work_keys_str_mv	AT xuezeng highincidenceofdistantmetastasisisassociatedwithhistopathologicalsubtypeofpediatricpapillarythyroidcanceraretrospectiveanalysisbasedonseer AT zhihongwang highincidenceofdistantmetastasisisassociatedwithhistopathologicalsubtypeofpediatricpapillarythyroidcanceraretrospectiveanalysisbasedonseer AT zhiqianggui highincidenceofdistantmetastasisisassociatedwithhistopathologicalsubtypeofpediatricpapillarythyroidcanceraretrospectiveanalysisbasedonseer AT jingzhexiang highincidenceofdistantmetastasisisassociatedwithhistopathologicalsubtypeofpediatricpapillarythyroidcanceraretrospectiveanalysisbasedonseer AT mengsucao highincidenceofdistantmetastasisisassociatedwithhistopathologicalsubtypeofpediatricpapillarythyroidcanceraretrospectiveanalysisbasedonseer AT weisun highincidenceofdistantmetastasisisassociatedwithhistopathologicalsubtypeofpediatricpapillarythyroidcanceraretrospectiveanalysisbasedonseer AT lianghe highincidenceofdistantmetastasisisassociatedwithhistopathologicalsubtypeofpediatricpapillarythyroidcanceraretrospectiveanalysisbasedonseer AT wenwudong highincidenceofdistantmetastasisisassociatedwithhistopathologicalsubtypeofpediatricpapillarythyroidcanceraretrospectiveanalysisbasedonseer AT jiapenghuang highincidenceofdistantmetastasisisassociatedwithhistopathologicalsubtypeofpediatricpapillarythyroidcanceraretrospectiveanalysisbasedonseer AT dalinzhang highincidenceofdistantmetastasisisassociatedwithhistopathologicalsubtypeofpediatricpapillarythyroidcanceraretrospectiveanalysisbasedonseer AT chengzhoulv highincidenceofdistantmetastasisisassociatedwithhistopathologicalsubtypeofpediatricpapillarythyroidcanceraretrospectiveanalysisbasedonseer AT tingzhang highincidenceofdistantmetastasisisassociatedwithhistopathologicalsubtypeofpediatricpapillarythyroidcanceraretrospectiveanalysisbasedonseer AT liangshao highincidenceofdistantmetastasisisassociatedwithhistopathologicalsubtypeofpediatricpapillarythyroidcanceraretrospectiveanalysisbasedonseer AT pingzhang highincidenceofdistantmetastasisisassociatedwithhistopathologicalsubtypeofpediatricpapillarythyroidcanceraretrospectiveanalysisbasedonseer AT haozhang highincidenceofdistantmetastasisisassociatedwithhistopathologicalsubtypeofpediatricpapillarythyroidcanceraretrospectiveanalysisbasedonseer
_version_	1718439211029233664

High Incidence of Distant Metastasis Is Associated With Histopathological Subtype of Pediatric Papillary Thyroid Cancer - a Retrospective Analysis Based on SEER

Ejemplares similares