Pupillary light reflex in ethambutol-induced optic neuropathy

Abstract We evaluated changes in the pupillary light reflex (PLR) of ethambutol (EMB)-induced optic neuropathy and analyzed the correlations between PLR parameters and other structural changes in EMB-induced optic neuropathy. This retrospective, observational, case–control study involved thirty-two...

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Autores principales:	Yung-Ju Yoo, Jeong-Min Hwang, Hee Kyung Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/494c6f146a3b4f3e9d05cf7f6d95297a
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spelling	oai:doaj.org-article:494c6f146a3b4f3e9d05cf7f6d95297a2021-12-02T12:33:04ZPupillary light reflex in ethambutol-induced optic neuropathy10.1038/s41598-020-77160-52045-2322https://doaj.org/article/494c6f146a3b4f3e9d05cf7f6d95297a2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77160-5https://doaj.org/toc/2045-2322Abstract We evaluated changes in the pupillary light reflex (PLR) of ethambutol (EMB)-induced optic neuropathy and analyzed the correlations between PLR parameters and other structural changes in EMB-induced optic neuropathy. This retrospective, observational, case–control study involved thirty-two eyes of 17 patients with EMB-induced optic neuropathy (EON group), sixty eyes of 60 patients without EMB-induced optic neuropathy (non-EON group) while taking ethambutol, and forty-five eyes of 45 normal controls. PLR was measured by digital pupillometry. The clinical characteristics, optical coherence tomography measurements and PLR parameters including pupil diameter, constriction latency, constriction ratio/velocity, and dilation velocity were noted. The differences in PLR measurements were compared among the three groups. Correlations between PLR parameters and other structural parameters in EMB-induced optic neuropathy were evaluated. The pupillary constriction ratio, constriction and dilation velocities were significantly reduced in the EON group compared to the non-EON group and controls (all P < 0.05). In EMB-induced optic neuropathy, average outer macular ganglion cell layer (mGCL) thickness showed a significant correlation with the pupillary constriction ratio (ß = 4.14, P = 0.003) and maximal constriction velocity (ß = 1.08, P < 0.001). This study confirmed that pupillary constriction and dilation velocities were significantly decreased in patients with EMB-induced optic neuropathy, compared to normal controls. Digital pupillometry may be a useful tool in the evaluation of EMB-induced optic neuropathy.Yung-Ju YooJeong-Min HwangHee Kyung YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-6 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yung-Ju Yoo Jeong-Min Hwang Hee Kyung Yang Pupillary light reflex in ethambutol-induced optic neuropathy
description	Abstract We evaluated changes in the pupillary light reflex (PLR) of ethambutol (EMB)-induced optic neuropathy and analyzed the correlations between PLR parameters and other structural changes in EMB-induced optic neuropathy. This retrospective, observational, case–control study involved thirty-two eyes of 17 patients with EMB-induced optic neuropathy (EON group), sixty eyes of 60 patients without EMB-induced optic neuropathy (non-EON group) while taking ethambutol, and forty-five eyes of 45 normal controls. PLR was measured by digital pupillometry. The clinical characteristics, optical coherence tomography measurements and PLR parameters including pupil diameter, constriction latency, constriction ratio/velocity, and dilation velocity were noted. The differences in PLR measurements were compared among the three groups. Correlations between PLR parameters and other structural parameters in EMB-induced optic neuropathy were evaluated. The pupillary constriction ratio, constriction and dilation velocities were significantly reduced in the EON group compared to the non-EON group and controls (all P < 0.05). In EMB-induced optic neuropathy, average outer macular ganglion cell layer (mGCL) thickness showed a significant correlation with the pupillary constriction ratio (ß = 4.14, P = 0.003) and maximal constriction velocity (ß = 1.08, P < 0.001). This study confirmed that pupillary constriction and dilation velocities were significantly decreased in patients with EMB-induced optic neuropathy, compared to normal controls. Digital pupillometry may be a useful tool in the evaluation of EMB-induced optic neuropathy.
format	article
author	Yung-Ju Yoo Jeong-Min Hwang Hee Kyung Yang
author_facet	Yung-Ju Yoo Jeong-Min Hwang Hee Kyung Yang
author_sort	Yung-Ju Yoo
title	Pupillary light reflex in ethambutol-induced optic neuropathy
title_short	Pupillary light reflex in ethambutol-induced optic neuropathy
title_full	Pupillary light reflex in ethambutol-induced optic neuropathy
title_fullStr	Pupillary light reflex in ethambutol-induced optic neuropathy
title_full_unstemmed	Pupillary light reflex in ethambutol-induced optic neuropathy
title_sort	pupillary light reflex in ethambutol-induced optic neuropathy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/494c6f146a3b4f3e9d05cf7f6d95297a
work_keys_str_mv	AT yungjuyoo pupillarylightreflexinethambutolinducedopticneuropathy AT jeongminhwang pupillarylightreflexinethambutolinducedopticneuropathy AT heekyungyang pupillarylightreflexinethambutolinducedopticneuropathy
_version_	1718393855899860992

Pupillary light reflex in ethambutol-induced optic neuropathy

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