Context-specific action of macrolide antibiotics on the eukaryotic ribosome

Macrolide antibiotics inhibit bacterial translation in a context-specific manner, arresting ribosomes at defined sites within mRNAs and selectively inhibiting synthesis of only a subset of cellular proteins. Here the authors provide a structural basis for the context-specific activity of macrolides...

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Autores principales:	Maxim S. Svetlov, Timm O. Koller, Sezen Meydan, Vaishnavi Shankar, Dorota Klepacki, Norbert Polacek, Nicholas R. Guydosh, Nora Vázquez-Laslop, Daniel N. Wilson, Alexander S. Mankin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/494f279037aa4f0d861c4a268dfa4d94
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spelling	oai:doaj.org-article:494f279037aa4f0d861c4a268dfa4d942021-12-02T17:15:21ZContext-specific action of macrolide antibiotics on the eukaryotic ribosome10.1038/s41467-021-23068-12041-1723https://doaj.org/article/494f279037aa4f0d861c4a268dfa4d942021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23068-1https://doaj.org/toc/2041-1723Macrolide antibiotics inhibit bacterial translation in a context-specific manner, arresting ribosomes at defined sites within mRNAs and selectively inhibiting synthesis of only a subset of cellular proteins. Here the authors provide a structural basis for the context-specific activity of macrolides on the eukaryotic ribosome.Maxim S. SvetlovTimm O. KollerSezen MeydanVaishnavi ShankarDorota KlepackiNorbert PolacekNicholas R. GuydoshNora Vázquez-LaslopDaniel N. WilsonAlexander S. MankinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maxim S. Svetlov Timm O. Koller Sezen Meydan Vaishnavi Shankar Dorota Klepacki Norbert Polacek Nicholas R. Guydosh Nora Vázquez-Laslop Daniel N. Wilson Alexander S. Mankin Context-specific action of macrolide antibiotics on the eukaryotic ribosome
description	Macrolide antibiotics inhibit bacterial translation in a context-specific manner, arresting ribosomes at defined sites within mRNAs and selectively inhibiting synthesis of only a subset of cellular proteins. Here the authors provide a structural basis for the context-specific activity of macrolides on the eukaryotic ribosome.
format	article
author	Maxim S. Svetlov Timm O. Koller Sezen Meydan Vaishnavi Shankar Dorota Klepacki Norbert Polacek Nicholas R. Guydosh Nora Vázquez-Laslop Daniel N. Wilson Alexander S. Mankin
author_facet	Maxim S. Svetlov Timm O. Koller Sezen Meydan Vaishnavi Shankar Dorota Klepacki Norbert Polacek Nicholas R. Guydosh Nora Vázquez-Laslop Daniel N. Wilson Alexander S. Mankin
author_sort	Maxim S. Svetlov
title	Context-specific action of macrolide antibiotics on the eukaryotic ribosome
title_short	Context-specific action of macrolide antibiotics on the eukaryotic ribosome
title_full	Context-specific action of macrolide antibiotics on the eukaryotic ribosome
title_fullStr	Context-specific action of macrolide antibiotics on the eukaryotic ribosome
title_full_unstemmed	Context-specific action of macrolide antibiotics on the eukaryotic ribosome
title_sort	context-specific action of macrolide antibiotics on the eukaryotic ribosome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/494f279037aa4f0d861c4a268dfa4d94
work_keys_str_mv	AT maximssvetlov contextspecificactionofmacrolideantibioticsontheeukaryoticribosome AT timmokoller contextspecificactionofmacrolideantibioticsontheeukaryoticribosome AT sezenmeydan contextspecificactionofmacrolideantibioticsontheeukaryoticribosome AT vaishnavishankar contextspecificactionofmacrolideantibioticsontheeukaryoticribosome AT dorotaklepacki contextspecificactionofmacrolideantibioticsontheeukaryoticribosome AT norbertpolacek contextspecificactionofmacrolideantibioticsontheeukaryoticribosome AT nicholasrguydosh contextspecificactionofmacrolideantibioticsontheeukaryoticribosome AT noravazquezlaslop contextspecificactionofmacrolideantibioticsontheeukaryoticribosome AT danielnwilson contextspecificactionofmacrolideantibioticsontheeukaryoticribosome AT alexandersmankin contextspecificactionofmacrolideantibioticsontheeukaryoticribosome
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Context-specific action of macrolide antibiotics on the eukaryotic ribosome

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