A Pan-Cancer Landscape of HOX-Related lncRNAs and Their Association With Prognosis and Tumor Microenvironment

The highly conserved homology cassette family (HOX) as well as 18 referenced long non-coding antisense transcripts (HOXATs) play vital roles in the development of some cancers. Nevertheless, their expression patterns as well as their association with cancer prognosis and the tumor microenvironment (...

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Autores principales:	Wei Shao, Qian Ding, Yugang Guo, Juan Xing, Zheng Huo, Zhan Wang, Qian Xu, Yue Guo
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	homology cassette HOX long non-coding RNA prognostic signature cancer immunity immune infiltration Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4950dffe2e02499baef1bb95fc08bc4c
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spelling	oai:doaj.org-article:4950dffe2e02499baef1bb95fc08bc4c2021-11-05T05:26:03ZA Pan-Cancer Landscape of HOX-Related lncRNAs and Their Association With Prognosis and Tumor Microenvironment2296-889X10.3389/fmolb.2021.767856https://doaj.org/article/4950dffe2e02499baef1bb95fc08bc4c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.767856/fullhttps://doaj.org/toc/2296-889XThe highly conserved homology cassette family (HOX) as well as 18 referenced long non-coding antisense transcripts (HOXATs) play vital roles in the development of some cancers. Nevertheless, their expression patterns as well as their association with cancer prognosis and the tumor microenvironment (TME) in pan-cancers are still unclear. Here, based on public databases, the expression levels of HOXATs, their prognostic potentials, and correlation with tumor mutation burden (TMB), immune cell infiltration, immune subtype, immune response-related genes, and stemness scores corresponding to 33 tumor types were analyzed systematically using R language. The results of the analysis indicated that different cancer tissues show different HOXAT expression profiles. Further, HOXAT expression showed association with cancer prognosis and immune and stemness regulation. Gene set enrichment analysis also demonstrated that HOXATs participate in cancer- and immune-related pathways, and based on their expression levels, HOTAIRM1 and HOXB-AS1 showed potential involvement in oncogenesis as well as possible involvement in immune regulation across a variety of cancer types. Further investigation also confirmed a significantly higher expression of HOXB-AS1 in GBM than in lower grade glioma tissues. Importantly, in vitro cell function experiments indicated that HOXB-AS1 supports cancer stem cell and plays a fundamental role in glioma metastasis. In conclusion, our results provide valuable resources that can guide the investigation of the mechanisms related to the role of HOXATs in cancers as well as therapeutic analysis in this regard.Wei ShaoQian DingYugang GuoJuan XingZheng HuoZhan WangQian XuYue GuoFrontiers Media S.A.articlehomology cassette HOXlong non-coding RNAprognostic signaturecancer immunityimmune infiltrationBiology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	homology cassette HOX long non-coding RNA prognostic signature cancer immunity immune infiltration Biology (General) QH301-705.5
spellingShingle	homology cassette HOX long non-coding RNA prognostic signature cancer immunity immune infiltration Biology (General) QH301-705.5 Wei Shao Qian Ding Yugang Guo Juan Xing Zheng Huo Zhan Wang Qian Xu Yue Guo A Pan-Cancer Landscape of HOX-Related lncRNAs and Their Association With Prognosis and Tumor Microenvironment
description	The highly conserved homology cassette family (HOX) as well as 18 referenced long non-coding antisense transcripts (HOXATs) play vital roles in the development of some cancers. Nevertheless, their expression patterns as well as their association with cancer prognosis and the tumor microenvironment (TME) in pan-cancers are still unclear. Here, based on public databases, the expression levels of HOXATs, their prognostic potentials, and correlation with tumor mutation burden (TMB), immune cell infiltration, immune subtype, immune response-related genes, and stemness scores corresponding to 33 tumor types were analyzed systematically using R language. The results of the analysis indicated that different cancer tissues show different HOXAT expression profiles. Further, HOXAT expression showed association with cancer prognosis and immune and stemness regulation. Gene set enrichment analysis also demonstrated that HOXATs participate in cancer- and immune-related pathways, and based on their expression levels, HOTAIRM1 and HOXB-AS1 showed potential involvement in oncogenesis as well as possible involvement in immune regulation across a variety of cancer types. Further investigation also confirmed a significantly higher expression of HOXB-AS1 in GBM than in lower grade glioma tissues. Importantly, in vitro cell function experiments indicated that HOXB-AS1 supports cancer stem cell and plays a fundamental role in glioma metastasis. In conclusion, our results provide valuable resources that can guide the investigation of the mechanisms related to the role of HOXATs in cancers as well as therapeutic analysis in this regard.
format	article
author	Wei Shao Qian Ding Yugang Guo Juan Xing Zheng Huo Zhan Wang Qian Xu Yue Guo
author_facet	Wei Shao Qian Ding Yugang Guo Juan Xing Zheng Huo Zhan Wang Qian Xu Yue Guo
author_sort	Wei Shao
title	A Pan-Cancer Landscape of HOX-Related lncRNAs and Their Association With Prognosis and Tumor Microenvironment
title_short	A Pan-Cancer Landscape of HOX-Related lncRNAs and Their Association With Prognosis and Tumor Microenvironment
title_full	A Pan-Cancer Landscape of HOX-Related lncRNAs and Their Association With Prognosis and Tumor Microenvironment
title_fullStr	A Pan-Cancer Landscape of HOX-Related lncRNAs and Their Association With Prognosis and Tumor Microenvironment
title_full_unstemmed	A Pan-Cancer Landscape of HOX-Related lncRNAs and Their Association With Prognosis and Tumor Microenvironment
title_sort	pan-cancer landscape of hox-related lncrnas and their association with prognosis and tumor microenvironment
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/4950dffe2e02499baef1bb95fc08bc4c
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A Pan-Cancer Landscape of HOX-Related lncRNAs and Their Association With Prognosis and Tumor Microenvironment

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