Non-IgE-Mediated Gastrointestinal Food Protein-Induced Allergic Disorders. Clinical Perspectives and Analytical Approaches

Non-IgE-mediated gastrointestinal food allergy (non-IgE-GI-FA) is the name given to a series of pathologies whose main entities are food protein-induced allergic proctocolitis (FPIAP), food protein-induced enteropathy (FPE), and food protein-induced enterocolitis syndrome (FPIES). These are more unc...

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Autores principales:	Elisa Zubeldia-Varela, Tomás Clive Barker-Tejeda, Frank Blanco-Pérez, Sonsoles Infante, José M. Zubeldia, Marina Pérez-Gordo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	food allergy non-IgE-mediated gastrointestinal food allergy cow’s milk food protein-induced enterocolitis syndrome food protein-induced allergic proctocolitis food protein-induced enteropathy Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/49544dcad9e9445683b7e9f8a0a67849
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spelling	oai:doaj.org-article:49544dcad9e9445683b7e9f8a0a678492021-11-25T17:33:56ZNon-IgE-Mediated Gastrointestinal Food Protein-Induced Allergic Disorders. Clinical Perspectives and Analytical Approaches10.3390/foods101126622304-8158https://doaj.org/article/49544dcad9e9445683b7e9f8a0a678492021-11-01T00:00:00Zhttps://www.mdpi.com/2304-8158/10/11/2662https://doaj.org/toc/2304-8158Non-IgE-mediated gastrointestinal food allergy (non-IgE-GI-FA) is the name given to a series of pathologies whose main entities are food protein-induced allergic proctocolitis (FPIAP), food protein-induced enteropathy (FPE), and food protein-induced enterocolitis syndrome (FPIES). These are more uncommon than IgE-mediated food allergies, their mechanisms remain largely unknown, and their diagnosis is mainly done by clinical history, due to the lack of specific biomarkers. In this review, we present the latest advances found in the literature about clinical aspects, the current diagnosis, and treatment options of non-IgE-GI-FAs. We discuss the use of animal models, the analysis of gut microbiota, omics techniques, and fecal proteins with a focus on understanding the pathophysiological mechanisms of these pathologies and obtaining possible diagnostic and/or prognostic biomarkers. Finally, we discuss the unmet needs that researchers should tackle to advance in the knowledge of these barely explored pathologies.Elisa Zubeldia-VarelaTomás Clive Barker-TejedaFrank Blanco-PérezSonsoles InfanteJosé M. ZubeldiaMarina Pérez-GordoMDPI AGarticlefood allergynon-IgE-mediated gastrointestinal food allergycow’s milkfood protein-induced enterocolitis syndromefood protein-induced allergic proctocolitisfood protein-induced enteropathyChemical technologyTP1-1185ENFoods, Vol 10, Iss 2662, p 2662 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	food allergy non-IgE-mediated gastrointestinal food allergy cow’s milk food protein-induced enterocolitis syndrome food protein-induced allergic proctocolitis food protein-induced enteropathy Chemical technology TP1-1185
spellingShingle	food allergy non-IgE-mediated gastrointestinal food allergy cow’s milk food protein-induced enterocolitis syndrome food protein-induced allergic proctocolitis food protein-induced enteropathy Chemical technology TP1-1185 Elisa Zubeldia-Varela Tomás Clive Barker-Tejeda Frank Blanco-Pérez Sonsoles Infante José M. Zubeldia Marina Pérez-Gordo Non-IgE-Mediated Gastrointestinal Food Protein-Induced Allergic Disorders. Clinical Perspectives and Analytical Approaches
description	Non-IgE-mediated gastrointestinal food allergy (non-IgE-GI-FA) is the name given to a series of pathologies whose main entities are food protein-induced allergic proctocolitis (FPIAP), food protein-induced enteropathy (FPE), and food protein-induced enterocolitis syndrome (FPIES). These are more uncommon than IgE-mediated food allergies, their mechanisms remain largely unknown, and their diagnosis is mainly done by clinical history, due to the lack of specific biomarkers. In this review, we present the latest advances found in the literature about clinical aspects, the current diagnosis, and treatment options of non-IgE-GI-FAs. We discuss the use of animal models, the analysis of gut microbiota, omics techniques, and fecal proteins with a focus on understanding the pathophysiological mechanisms of these pathologies and obtaining possible diagnostic and/or prognostic biomarkers. Finally, we discuss the unmet needs that researchers should tackle to advance in the knowledge of these barely explored pathologies.
format	article
author	Elisa Zubeldia-Varela Tomás Clive Barker-Tejeda Frank Blanco-Pérez Sonsoles Infante José M. Zubeldia Marina Pérez-Gordo
author_facet	Elisa Zubeldia-Varela Tomás Clive Barker-Tejeda Frank Blanco-Pérez Sonsoles Infante José M. Zubeldia Marina Pérez-Gordo
author_sort	Elisa Zubeldia-Varela
title	Non-IgE-Mediated Gastrointestinal Food Protein-Induced Allergic Disorders. Clinical Perspectives and Analytical Approaches
title_short	Non-IgE-Mediated Gastrointestinal Food Protein-Induced Allergic Disorders. Clinical Perspectives and Analytical Approaches
title_full	Non-IgE-Mediated Gastrointestinal Food Protein-Induced Allergic Disorders. Clinical Perspectives and Analytical Approaches
title_fullStr	Non-IgE-Mediated Gastrointestinal Food Protein-Induced Allergic Disorders. Clinical Perspectives and Analytical Approaches
title_full_unstemmed	Non-IgE-Mediated Gastrointestinal Food Protein-Induced Allergic Disorders. Clinical Perspectives and Analytical Approaches
title_sort	non-ige-mediated gastrointestinal food protein-induced allergic disorders. clinical perspectives and analytical approaches
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/49544dcad9e9445683b7e9f8a0a67849
work_keys_str_mv	AT elisazubeldiavarela nonigemediatedgastrointestinalfoodproteininducedallergicdisordersclinicalperspectivesandanalyticalapproaches AT tomasclivebarkertejeda nonigemediatedgastrointestinalfoodproteininducedallergicdisordersclinicalperspectivesandanalyticalapproaches AT frankblancoperez nonigemediatedgastrointestinalfoodproteininducedallergicdisordersclinicalperspectivesandanalyticalapproaches AT sonsolesinfante nonigemediatedgastrointestinalfoodproteininducedallergicdisordersclinicalperspectivesandanalyticalapproaches AT josemzubeldia nonigemediatedgastrointestinalfoodproteininducedallergicdisordersclinicalperspectivesandanalyticalapproaches AT marinaperezgordo nonigemediatedgastrointestinalfoodproteininducedallergicdisordersclinicalperspectivesandanalyticalapproaches
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Non-IgE-Mediated Gastrointestinal Food Protein-Induced Allergic Disorders. Clinical Perspectives and Analytical Approaches

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