Tor forms a dimer through an N-terminal helical solenoid with a complex topology

The target of rapamycin (Tor) is a Ser/Thr protein kinase that regulates a wide range of anabolic and catabolic processes. Here the authors describe a sub-nanometer cryo-EM structure of a yeast Tor–Lst8 complex and propose an overall topology that differs from that previously suggested for mTORC1.

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Auteurs principaux:	Domagoj Baretić, Alex Berndt, Yohei Ohashi, Christopher M. Johnson, Roger L. Williams
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2016
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/495475276f274418a28c2305a92b7244
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spelling	oai:doaj.org-article:495475276f274418a28c2305a92b72442021-12-02T15:35:01ZTor forms a dimer through an N-terminal helical solenoid with a complex topology10.1038/ncomms110162041-1723https://doaj.org/article/495475276f274418a28c2305a92b72442016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11016https://doaj.org/toc/2041-1723The target of rapamycin (Tor) is a Ser/Thr protein kinase that regulates a wide range of anabolic and catabolic processes. Here the authors describe a sub-nanometer cryo-EM structure of a yeast Tor–Lst8 complex and propose an overall topology that differs from that previously suggested for mTORC1.Domagoj BaretićAlex BerndtYohei OhashiChristopher M. JohnsonRoger L. WilliamsNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Domagoj Baretić Alex Berndt Yohei Ohashi Christopher M. Johnson Roger L. Williams Tor forms a dimer through an N-terminal helical solenoid with a complex topology
description	The target of rapamycin (Tor) is a Ser/Thr protein kinase that regulates a wide range of anabolic and catabolic processes. Here the authors describe a sub-nanometer cryo-EM structure of a yeast Tor–Lst8 complex and propose an overall topology that differs from that previously suggested for mTORC1.
format	article
author	Domagoj Baretić Alex Berndt Yohei Ohashi Christopher M. Johnson Roger L. Williams
author_facet	Domagoj Baretić Alex Berndt Yohei Ohashi Christopher M. Johnson Roger L. Williams
author_sort	Domagoj Baretić
title	Tor forms a dimer through an N-terminal helical solenoid with a complex topology
title_short	Tor forms a dimer through an N-terminal helical solenoid with a complex topology
title_full	Tor forms a dimer through an N-terminal helical solenoid with a complex topology
title_fullStr	Tor forms a dimer through an N-terminal helical solenoid with a complex topology
title_full_unstemmed	Tor forms a dimer through an N-terminal helical solenoid with a complex topology
title_sort	tor forms a dimer through an n-terminal helical solenoid with a complex topology
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/495475276f274418a28c2305a92b7244
work_keys_str_mv	AT domagojbaretic torformsadimerthroughannterminalhelicalsolenoidwithacomplextopology AT alexberndt torformsadimerthroughannterminalhelicalsolenoidwithacomplextopology AT yoheiohashi torformsadimerthroughannterminalhelicalsolenoidwithacomplextopology AT christophermjohnson torformsadimerthroughannterminalhelicalsolenoidwithacomplextopology AT rogerlwilliams torformsadimerthroughannterminalhelicalsolenoidwithacomplextopology
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Tor forms a dimer through an N-terminal helical solenoid with a complex topology

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