Survival landscape of different tumor regression grades and pathologic complete response in rectal cancer after neoadjuvant therapy based on reconstructed individual patient data

Abstract Background Neoadjuvant therapy can lead to different tumor regression grades (TRG) in rectal cancer after neoadjuvant therapy. The purposes of this study are to investigate the relationships among TRG, pathologic complete response (pCR) and long-term survival, on the basis of reconstructed...

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Autores principales:	Jia-yi Li, Xuan-zhang Huang, Peng Gao, Yong-xi Song, Xiao-wan Chen, Xing-er Lv, Yv Fu, Qiong Xiao, Shi-yv Ye, Zhen-ning Wang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Rectal cancer Neoadjuvant therapy Pathological complete response Tumor regression grade Survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/4954ec4b091b4a899a745afe74bf1b92
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spelling	oai:doaj.org-article:4954ec4b091b4a899a745afe74bf1b922021-11-14T12:29:54ZSurvival landscape of different tumor regression grades and pathologic complete response in rectal cancer after neoadjuvant therapy based on reconstructed individual patient data10.1186/s12885-021-08922-11471-2407https://doaj.org/article/4954ec4b091b4a899a745afe74bf1b922021-11-01T00:00:00Zhttps://doi.org/10.1186/s12885-021-08922-1https://doaj.org/toc/1471-2407Abstract Background Neoadjuvant therapy can lead to different tumor regression grades (TRG) in rectal cancer after neoadjuvant therapy. The purposes of this study are to investigate the relationships among TRG, pathologic complete response (pCR) and long-term survival, on the basis of reconstructed individual patient data (IPD). Methods The PubMed, Embase, Ovid and Cochrane CENTRAL databases were searched. The primary endpoint was to evaluate the survival landscape of different TRGs after neoadjuvant therapy and the secondary endpoint was to evaluate the associations between pCR and survival. IPD were reconstructed with Kaplan–Meier curves. Results The 10-year overall survival (OS) and 5-year disease-free survival (DFS) were clearly higher in the pCR group than in the non-pCR (npCR) group (80.5% vs. 48.3, 90.1% vs. 69.8%). Furthermore, the OS and DFS increased with improvement in tumor regression after neoadjuvant therapy. According to the IPD, the pCR group had longer OS (HR = 0.240, 95% CI = 0.177–0.325, p < 0.001) and DFS (HR = 0.274, 95% CI = 0.205–0.367, p < 0.001) than the npCR group. Better tumor regression was associated with better survival outcomes (p < 0.005). Direct calculation of published HR values yielded similar results. Conclusions Our results indicate a positive relationship between better tumor regressions and improved survival benefits among the npCR group and patients with rectal cancer achieving pCR had much longer OS and DFS than patients achieving npCR, presenting a survival landscape of different TRGs and pCR in rectal cancer after neoadjuvant therapy.Jia-yi LiXuan-zhang HuangPeng GaoYong-xi SongXiao-wan ChenXing-er LvYv FuQiong XiaoShi-yv YeZhen-ning WangBMCarticleRectal cancerNeoadjuvant therapyPathological complete responseTumor regression gradeSurvivalNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBMC Cancer, Vol 21, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Rectal cancer Neoadjuvant therapy Pathological complete response Tumor regression grade Survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Rectal cancer Neoadjuvant therapy Pathological complete response Tumor regression grade Survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jia-yi Li Xuan-zhang Huang Peng Gao Yong-xi Song Xiao-wan Chen Xing-er Lv Yv Fu Qiong Xiao Shi-yv Ye Zhen-ning Wang Survival landscape of different tumor regression grades and pathologic complete response in rectal cancer after neoadjuvant therapy based on reconstructed individual patient data
description	Abstract Background Neoadjuvant therapy can lead to different tumor regression grades (TRG) in rectal cancer after neoadjuvant therapy. The purposes of this study are to investigate the relationships among TRG, pathologic complete response (pCR) and long-term survival, on the basis of reconstructed individual patient data (IPD). Methods The PubMed, Embase, Ovid and Cochrane CENTRAL databases were searched. The primary endpoint was to evaluate the survival landscape of different TRGs after neoadjuvant therapy and the secondary endpoint was to evaluate the associations between pCR and survival. IPD were reconstructed with Kaplan–Meier curves. Results The 10-year overall survival (OS) and 5-year disease-free survival (DFS) were clearly higher in the pCR group than in the non-pCR (npCR) group (80.5% vs. 48.3, 90.1% vs. 69.8%). Furthermore, the OS and DFS increased with improvement in tumor regression after neoadjuvant therapy. According to the IPD, the pCR group had longer OS (HR = 0.240, 95% CI = 0.177–0.325, p < 0.001) and DFS (HR = 0.274, 95% CI = 0.205–0.367, p < 0.001) than the npCR group. Better tumor regression was associated with better survival outcomes (p < 0.005). Direct calculation of published HR values yielded similar results. Conclusions Our results indicate a positive relationship between better tumor regressions and improved survival benefits among the npCR group and patients with rectal cancer achieving pCR had much longer OS and DFS than patients achieving npCR, presenting a survival landscape of different TRGs and pCR in rectal cancer after neoadjuvant therapy.
format	article
author	Jia-yi Li Xuan-zhang Huang Peng Gao Yong-xi Song Xiao-wan Chen Xing-er Lv Yv Fu Qiong Xiao Shi-yv Ye Zhen-ning Wang
author_facet	Jia-yi Li Xuan-zhang Huang Peng Gao Yong-xi Song Xiao-wan Chen Xing-er Lv Yv Fu Qiong Xiao Shi-yv Ye Zhen-ning Wang
author_sort	Jia-yi Li
title	Survival landscape of different tumor regression grades and pathologic complete response in rectal cancer after neoadjuvant therapy based on reconstructed individual patient data
title_short	Survival landscape of different tumor regression grades and pathologic complete response in rectal cancer after neoadjuvant therapy based on reconstructed individual patient data
title_full	Survival landscape of different tumor regression grades and pathologic complete response in rectal cancer after neoadjuvant therapy based on reconstructed individual patient data
title_fullStr	Survival landscape of different tumor regression grades and pathologic complete response in rectal cancer after neoadjuvant therapy based on reconstructed individual patient data
title_full_unstemmed	Survival landscape of different tumor regression grades and pathologic complete response in rectal cancer after neoadjuvant therapy based on reconstructed individual patient data
title_sort	survival landscape of different tumor regression grades and pathologic complete response in rectal cancer after neoadjuvant therapy based on reconstructed individual patient data
publisher	BMC
publishDate	2021
url	https://doaj.org/article/4954ec4b091b4a899a745afe74bf1b92
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Survival landscape of different tumor regression grades and pathologic complete response in rectal cancer after neoadjuvant therapy based on reconstructed individual patient data

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