Antibacterial properties of silver nanoparticles synthesized using Pulicaria glutinosa plant extract as a green bioreductant

Mujeeb Khan,1 Shams Tabrez Khan,2 Merajuddin Khan,1 Syed Farooq Adil,1 Javed Musarrat,2 Abdulaziz A Al-Khedhairy,2 Abdulrahman Al-Warthan,1 Mohammed Rafiq H Siddiqui,1 Hamad Z Alkhathlan1 1Department of Chemistry, 2Zoology Department, College of Science, King Saud University, Riyadh, Kingdom&n...

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Autores principales:	Khan M, Khan ST, Adil SF, Musarrat J, Al-Khedhairy AA, Al-Warthan A, Siddiqui MRH, Alkhathlan HZ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/495a300165d145c0b4e3c9948d5f6887
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spelling	oai:doaj.org-article:495a300165d145c0b4e3c9948d5f68872021-12-02T02:01:47ZAntibacterial properties of silver nanoparticles synthesized using Pulicaria glutinosa plant extract as a green bioreductant1178-2013https://doaj.org/article/495a300165d145c0b4e3c9948d5f68872014-07-01T00:00:00Zhttp://www.dovepress.com/antibacterial-properties-of-silver-nanoparticles-synthesized-using-pul-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Mujeeb Khan,1 Shams Tabrez Khan,2 Merajuddin Khan,1 Syed Farooq Adil,1 Javed Musarrat,2 Abdulaziz A Al-Khedhairy,2 Abdulrahman Al-Warthan,1 Mohammed Rafiq H Siddiqui,1 Hamad Z Alkhathlan1 1Department of Chemistry, 2Zoology Department, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia Abstract: The antibacterial properties of nanoparticles (NPs) can be significantly enhanced by increasing the wettability or solubility of NPs in aqueous medium. In this study, we investigated the effects of the stabilizing agent on the solubility of silver NPs and its subsequent effect on their antimicrobial activities. Silver NPs were prepared using an aqueous solution of Pulicaria glutinosa plant extract as bioreductant. The solution also acts as a capping ligand. During this study, the antimicrobial activities of silver NPs, as well as the plant extract alone, were tested against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Micrococcus luteus. Silver NPs were prepared with various concentrations of the plant extract to study its effect on antimicrobial activity. Interestingly, various concentrations of P. glutinosa extract did not show any effect on the growth of tested bacteria; however, a significant effect on the antimicrobial property of plant extract capped silver NPs (Ag-NPs-PE) was observed. For instance, the half maximal inhibitory concentration values were found to decrease (from 4% to 21%) with the increasing concentrations of plant extract used for the synthesis of Ag-NPs-PE. These results clearly indicate that the addition of P. glutinosa extracts enhances the solubility of Ag-NPs-PE and, hence, increases their toxicity against the tested microorganisms. Keywords: antibacterial activity, silver nanoparticles, plant extract, Pulicaria glutinosaKhan MKhan STKhan MAdil SFMusarrat JAl-Khedhairy AAAl-Warthan ASiddiqui MRHAlkhathlan HZDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 3551-3565 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Khan M Khan ST Khan M Adil SF Musarrat J Al-Khedhairy AA Al-Warthan A Siddiqui MRH Alkhathlan HZ Antibacterial properties of silver nanoparticles synthesized using Pulicaria glutinosa plant extract as a green bioreductant
description	Mujeeb Khan,1 Shams Tabrez Khan,2 Merajuddin Khan,1 Syed Farooq Adil,1 Javed Musarrat,2 Abdulaziz A Al-Khedhairy,2 Abdulrahman Al-Warthan,1 Mohammed Rafiq H Siddiqui,1 Hamad Z Alkhathlan1 1Department of Chemistry, 2Zoology Department, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia Abstract: The antibacterial properties of nanoparticles (NPs) can be significantly enhanced by increasing the wettability or solubility of NPs in aqueous medium. In this study, we investigated the effects of the stabilizing agent on the solubility of silver NPs and its subsequent effect on their antimicrobial activities. Silver NPs were prepared using an aqueous solution of Pulicaria glutinosa plant extract as bioreductant. The solution also acts as a capping ligand. During this study, the antimicrobial activities of silver NPs, as well as the plant extract alone, were tested against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Micrococcus luteus. Silver NPs were prepared with various concentrations of the plant extract to study its effect on antimicrobial activity. Interestingly, various concentrations of P. glutinosa extract did not show any effect on the growth of tested bacteria; however, a significant effect on the antimicrobial property of plant extract capped silver NPs (Ag-NPs-PE) was observed. For instance, the half maximal inhibitory concentration values were found to decrease (from 4% to 21%) with the increasing concentrations of plant extract used for the synthesis of Ag-NPs-PE. These results clearly indicate that the addition of P. glutinosa extracts enhances the solubility of Ag-NPs-PE and, hence, increases their toxicity against the tested microorganisms. Keywords: antibacterial activity, silver nanoparticles, plant extract, Pulicaria glutinosa
format	article
author	Khan M Khan ST Khan M Adil SF Musarrat J Al-Khedhairy AA Al-Warthan A Siddiqui MRH Alkhathlan HZ
author_facet	Khan M Khan ST Khan M Adil SF Musarrat J Al-Khedhairy AA Al-Warthan A Siddiqui MRH Alkhathlan HZ
author_sort	Khan M
title	Antibacterial properties of silver nanoparticles synthesized using Pulicaria glutinosa plant extract as a green bioreductant
title_short	Antibacterial properties of silver nanoparticles synthesized using Pulicaria glutinosa plant extract as a green bioreductant
title_full	Antibacterial properties of silver nanoparticles synthesized using Pulicaria glutinosa plant extract as a green bioreductant
title_fullStr	Antibacterial properties of silver nanoparticles synthesized using Pulicaria glutinosa plant extract as a green bioreductant
title_full_unstemmed	Antibacterial properties of silver nanoparticles synthesized using Pulicaria glutinosa plant extract as a green bioreductant
title_sort	antibacterial properties of silver nanoparticles synthesized using pulicaria glutinosa plant extract as a green bioreductant
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/495a300165d145c0b4e3c9948d5f6887
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Antibacterial properties of silver nanoparticles synthesized using Pulicaria glutinosa plant extract as a green bioreductant

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