Benefit of a single simulated hypobaric hypoxia in healthy mice performance and analysis of mitochondria-related gene changes

Abstract Simulated hypobaric hypoxia (SHH) training has been used to enhance running performance. However, no studies have evaluated the effects of a single SHH exposure on healthy mice performance and analyzed the changes of mitochondria-related genes in the central nervous system. The current stud...

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Autores principales:	Fei-Fei Wu, Kun-Long Zhang, Zheng-Mei Wang, Yi Yang, Shao-Hua Li, Jia-Qi Wang, Jin Ma, Yan-Ling Yang, Hai-Feng Zhang, Ya-Yun Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/495e0ec9ccc8475fa030ad7f38289490
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spelling	oai:doaj.org-article:495e0ec9ccc8475fa030ad7f382894902021-12-02T11:37:25ZBenefit of a single simulated hypobaric hypoxia in healthy mice performance and analysis of mitochondria-related gene changes10.1038/s41598-020-80425-82045-2322https://doaj.org/article/495e0ec9ccc8475fa030ad7f382894902021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80425-8https://doaj.org/toc/2045-2322Abstract Simulated hypobaric hypoxia (SHH) training has been used to enhance running performance. However, no studies have evaluated the effects of a single SHH exposure on healthy mice performance and analyzed the changes of mitochondria-related genes in the central nervous system. The current study used a mouse decompression chamber to simulate mild hypobaric hypoxia at the high altitude of 5000 m or severe hypobaric hypoxia at 8000 m for 16 h (SHH5000 & SHH8000, respectively). Then, the mouse behavioral tests were recorded by a modified Noldus video tracking. Third, the effects of SHH on 8 mitochondria-related genes of Drp1, Mfn1, Mfn2, Opa1, TFAM, SGK1, UCP2 and UCP4, were assessed in cerebellum, hippocampus and gastrocnemius muscles. The results have shown that a single mild or severe HH improves healthy mice performance. In cerebellum, 6 of all 8 detected genes (except Mfn2 and UCP4) did not change after SHH. In hippocampus, all detected genes did not change after SHH. In muscles, 7 of all 8 detected genes (except Opa1) did not change after SHH. The present study has indicated the benefit of a single SHH in healthy mice performance, which would due to the stabilized mitochondria against a mild stress state.Fei-Fei WuKun-Long ZhangZheng-Mei WangYi YangShao-Hua LiJia-Qi WangJin MaYan-Ling YangHai-Feng ZhangYa-Yun WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fei-Fei Wu Kun-Long Zhang Zheng-Mei Wang Yi Yang Shao-Hua Li Jia-Qi Wang Jin Ma Yan-Ling Yang Hai-Feng Zhang Ya-Yun Wang Benefit of a single simulated hypobaric hypoxia in healthy mice performance and analysis of mitochondria-related gene changes
description	Abstract Simulated hypobaric hypoxia (SHH) training has been used to enhance running performance. However, no studies have evaluated the effects of a single SHH exposure on healthy mice performance and analyzed the changes of mitochondria-related genes in the central nervous system. The current study used a mouse decompression chamber to simulate mild hypobaric hypoxia at the high altitude of 5000 m or severe hypobaric hypoxia at 8000 m for 16 h (SHH5000 & SHH8000, respectively). Then, the mouse behavioral tests were recorded by a modified Noldus video tracking. Third, the effects of SHH on 8 mitochondria-related genes of Drp1, Mfn1, Mfn2, Opa1, TFAM, SGK1, UCP2 and UCP4, were assessed in cerebellum, hippocampus and gastrocnemius muscles. The results have shown that a single mild or severe HH improves healthy mice performance. In cerebellum, 6 of all 8 detected genes (except Mfn2 and UCP4) did not change after SHH. In hippocampus, all detected genes did not change after SHH. In muscles, 7 of all 8 detected genes (except Opa1) did not change after SHH. The present study has indicated the benefit of a single SHH in healthy mice performance, which would due to the stabilized mitochondria against a mild stress state.
format	article
author	Fei-Fei Wu Kun-Long Zhang Zheng-Mei Wang Yi Yang Shao-Hua Li Jia-Qi Wang Jin Ma Yan-Ling Yang Hai-Feng Zhang Ya-Yun Wang
author_facet	Fei-Fei Wu Kun-Long Zhang Zheng-Mei Wang Yi Yang Shao-Hua Li Jia-Qi Wang Jin Ma Yan-Ling Yang Hai-Feng Zhang Ya-Yun Wang
author_sort	Fei-Fei Wu
title	Benefit of a single simulated hypobaric hypoxia in healthy mice performance and analysis of mitochondria-related gene changes
title_short	Benefit of a single simulated hypobaric hypoxia in healthy mice performance and analysis of mitochondria-related gene changes
title_full	Benefit of a single simulated hypobaric hypoxia in healthy mice performance and analysis of mitochondria-related gene changes
title_fullStr	Benefit of a single simulated hypobaric hypoxia in healthy mice performance and analysis of mitochondria-related gene changes
title_full_unstemmed	Benefit of a single simulated hypobaric hypoxia in healthy mice performance and analysis of mitochondria-related gene changes
title_sort	benefit of a single simulated hypobaric hypoxia in healthy mice performance and analysis of mitochondria-related gene changes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/495e0ec9ccc8475fa030ad7f38289490
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Benefit of a single simulated hypobaric hypoxia in healthy mice performance and analysis of mitochondria-related gene changes

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