The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells

Abstract Background 4-hexylresorcinol (4HR) has been shown to have anti-oxidant activity similar to that of resveratrol. As resveratrol increases sirtuin (SIRT) activity, 4HR might behave similarly to resveratrol. Method In this study, the expression levels of SIRT1, SIRT3, and SIRT6 were evaluated...

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Autores principales:	In-Song Lee, Jun-Ho Chang, Dae-Won Kim, Seong-Gon Kim, Tae-Woo Kim
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	4-hexylresorcinol Sirtuin NAD+ Dentistry RK1-715 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/495ecab97de64170b2dd92b004672ff0
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spelling	oai:doaj.org-article:495ecab97de64170b2dd92b004672ff02021-11-08T10:45:04ZThe effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells10.1186/s40902-021-00326-22288-8586https://doaj.org/article/495ecab97de64170b2dd92b004672ff02021-11-01T00:00:00Zhttps://doi.org/10.1186/s40902-021-00326-2https://doaj.org/toc/2288-8586Abstract Background 4-hexylresorcinol (4HR) has been shown to have anti-oxidant activity similar to that of resveratrol. As resveratrol increases sirtuin (SIRT) activity, 4HR might behave similarly to resveratrol. Method In this study, the expression levels of SIRT1, SIRT3, and SIRT6 were evaluated after 4HR administration (1–100 μM). As NAD+ is a substrate for SIRTs, its levels with SIRT activity were also studied. Results In the results, SIRT3 (100 μM at 24 h) and SIRT6 (1–100 μM at 24 h and 10 μM at 8 h) were shown to have significantly higher expression levels compared to untreated control (p < 0.05). Pan-SIRT activity and the NAD+ level was significantly increased compared to that of the untreated control (p < 0.05; 10 and 100 μM at 24 h). Conclusion 4HR administration increased SIRT activity and the NAD+ level in Saos-2 cells.In-Song LeeJun-Ho ChangDae-Won KimSeong-Gon KimTae-Woo KimSpringerOpenarticle4-hexylresorcinolSirtuinNAD+DentistryRK1-715SurgeryRD1-811ENMaxillofacial Plastic and Reconstructive Surgery, Vol 43, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	4-hexylresorcinol Sirtuin NAD+ Dentistry RK1-715 Surgery RD1-811
spellingShingle	4-hexylresorcinol Sirtuin NAD+ Dentistry RK1-715 Surgery RD1-811 In-Song Lee Jun-Ho Chang Dae-Won Kim Seong-Gon Kim Tae-Woo Kim The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells
description	Abstract Background 4-hexylresorcinol (4HR) has been shown to have anti-oxidant activity similar to that of resveratrol. As resveratrol increases sirtuin (SIRT) activity, 4HR might behave similarly to resveratrol. Method In this study, the expression levels of SIRT1, SIRT3, and SIRT6 were evaluated after 4HR administration (1–100 μM). As NAD+ is a substrate for SIRTs, its levels with SIRT activity were also studied. Results In the results, SIRT3 (100 μM at 24 h) and SIRT6 (1–100 μM at 24 h and 10 μM at 8 h) were shown to have significantly higher expression levels compared to untreated control (p < 0.05). Pan-SIRT activity and the NAD+ level was significantly increased compared to that of the untreated control (p < 0.05; 10 and 100 μM at 24 h). Conclusion 4HR administration increased SIRT activity and the NAD+ level in Saos-2 cells.
format	article
author	In-Song Lee Jun-Ho Chang Dae-Won Kim Seong-Gon Kim Tae-Woo Kim
author_facet	In-Song Lee Jun-Ho Chang Dae-Won Kim Seong-Gon Kim Tae-Woo Kim
author_sort	In-Song Lee
title	The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells
title_short	The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells
title_full	The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells
title_fullStr	The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells
title_full_unstemmed	The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells
title_sort	effect of 4-hexylresorinol administration on nad+ level and sirt activity in saos-2 cells
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/495ecab97de64170b2dd92b004672ff0
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The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells

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