<named-content content-type="genus-species">Candida auris</named-content> Biofilm Colonization on Skin Niche Conditions

ABSTRACT Candida auris, an emerging multidrug-resistant yeast, has recently been associated with outbreaks of invasive infections in health care facilities worldwide. Its success as a nosocomial pathogen lies in its capability to sustain for prolonged periods in the intensive care unit (ICU), adeptl...

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Autor principal:	Priya Uppuluri
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	Candida auris biofilm skin porcine sweat nosocomial Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/4960e9deb6de44f2a0a35ded21cf9f46
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spelling	oai:doaj.org-article:4960e9deb6de44f2a0a35ded21cf9f462021-11-15T15:27:54Z<named-content content-type="genus-species">Candida auris</named-content> Biofilm Colonization on Skin Niche Conditions10.1128/mSphere.00972-192379-5042https://doaj.org/article/4960e9deb6de44f2a0a35ded21cf9f462020-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00972-19https://doaj.org/toc/2379-5042ABSTRACT Candida auris, an emerging multidrug-resistant yeast, has recently been associated with outbreaks of invasive infections in health care facilities worldwide. Its success as a nosocomial pathogen lies in its capability to sustain for prolonged periods in the intensive care unit (ICU), adeptly colonize skin, and spread among patients. Little is known of the mechanism behind the predilection of C. auris for skin or the extent of its resilience on it. Now, M. V. Horton, C. J. Johnson, J. F. Kernien, T. D. Patel, et al. (mSphere 5:e00910-19, 2020, https://doi.org/10.1128/mSphere.00910-19) demonstrate that in synthetic sweat medium designed to mimic axillary skin conditions, C. auris can grow into multilayers of cells called biofilms that can resist desiccation. C. auris’ propensity to form biofilms was further elaborated using a novel ex vivo porcine skin model of skin colonization. These studies provide early evidence that C. auris biofilm cells persisting on skin could serve as source of continuing outbreaks in health care facilities. Interventions blocking C. auris biofilm growth on skin will help control the spread of this pathogen.Priya UppuluriAmerican Society for MicrobiologyarticleCandida aurisbiofilmskinporcinesweatnosocomialMicrobiologyQR1-502ENmSphere, Vol 5, Iss 1 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Candida auris biofilm skin porcine sweat nosocomial Microbiology QR1-502
spellingShingle	Candida auris biofilm skin porcine sweat nosocomial Microbiology QR1-502 Priya Uppuluri <named-content content-type="genus-species">Candida auris</named-content> Biofilm Colonization on Skin Niche Conditions
description	ABSTRACT Candida auris, an emerging multidrug-resistant yeast, has recently been associated with outbreaks of invasive infections in health care facilities worldwide. Its success as a nosocomial pathogen lies in its capability to sustain for prolonged periods in the intensive care unit (ICU), adeptly colonize skin, and spread among patients. Little is known of the mechanism behind the predilection of C. auris for skin or the extent of its resilience on it. Now, M. V. Horton, C. J. Johnson, J. F. Kernien, T. D. Patel, et al. (mSphere 5:e00910-19, 2020, https://doi.org/10.1128/mSphere.00910-19) demonstrate that in synthetic sweat medium designed to mimic axillary skin conditions, C. auris can grow into multilayers of cells called biofilms that can resist desiccation. C. auris’ propensity to form biofilms was further elaborated using a novel ex vivo porcine skin model of skin colonization. These studies provide early evidence that C. auris biofilm cells persisting on skin could serve as source of continuing outbreaks in health care facilities. Interventions blocking C. auris biofilm growth on skin will help control the spread of this pathogen.
format	article
author	Priya Uppuluri
author_facet	Priya Uppuluri
author_sort	Priya Uppuluri
title	<named-content content-type="genus-species">Candida auris</named-content> Biofilm Colonization on Skin Niche Conditions
title_short	<named-content content-type="genus-species">Candida auris</named-content> Biofilm Colonization on Skin Niche Conditions
title_full	<named-content content-type="genus-species">Candida auris</named-content> Biofilm Colonization on Skin Niche Conditions
title_fullStr	<named-content content-type="genus-species">Candida auris</named-content> Biofilm Colonization on Skin Niche Conditions
title_full_unstemmed	<named-content content-type="genus-species">Candida auris</named-content> Biofilm Colonization on Skin Niche Conditions
title_sort	<named-content content-type="genus-species">candida auris</named-content> biofilm colonization on skin niche conditions
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/4960e9deb6de44f2a0a35ded21cf9f46
work_keys_str_mv	AT priyauppuluri namedcontentcontenttypegenusspeciescandidaaurisnamedcontentbiofilmcolonizationonskinnicheconditions
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<named-content content-type="genus-species">Candida auris</named-content> Biofilm Colonization on Skin Niche Conditions

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