Defining Dysbiosis in Patients with Urolithiasis

Abstract The prevalence of urinary stone disease (USD) is rapidly rising. However, the factors driving this increase are unknown. Recent microbiome studies suggest that dysbiosis may in part contribute to the increasing prevalence. The objective of the current study was to determine the nature and l...

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Autores principales:	Anna Zampini, Andrew H. Nguyen, Emily Rose, Manoj Monga, Aaron W. Miller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4965c2a35cb1470c8dcf88bc26c366de
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spelling	oai:doaj.org-article:4965c2a35cb1470c8dcf88bc26c366de2021-12-02T15:08:46ZDefining Dysbiosis in Patients with Urolithiasis10.1038/s41598-019-41977-62045-2322https://doaj.org/article/4965c2a35cb1470c8dcf88bc26c366de2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-41977-6https://doaj.org/toc/2045-2322Abstract The prevalence of urinary stone disease (USD) is rapidly rising. However, the factors driving this increase are unknown. Recent microbiome studies suggest that dysbiosis may in part contribute to the increasing prevalence. The objective of the current study was to determine the nature and location of dysbiosis associated with USD. We conducted microbiome analysis from the gastrointestinal and urinary tracts, along with a metabolomic analysis of the urinary metabolome, from subjects with an active episode of USD or no history of the disease. Higher rates of antibiotic use among USD patients along with integrated microbiome and metabolomic results support the hypothesis that USD is associated with an antibiotic-driven shift in the microbiome from one that protects against USD to one that promotes the disease. Specifically, our study implicates urinary tract Lactobacillus and Enterobacteriaceae in protective and pathogenic roles for USD, respectively, which conventional, culture-based methods of bacterial analysis from urine and kidney stones would not necessarily detect. Results suggest that antibiotics produce a long-term shift in the microbiome that may increase the risk for USD, with the urinary tract microbiome holding more relevance for USD than the gut microbiome.Anna ZampiniAndrew H. NguyenEmily RoseManoj MongaAaron W. MillerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anna Zampini Andrew H. Nguyen Emily Rose Manoj Monga Aaron W. Miller Defining Dysbiosis in Patients with Urolithiasis
description	Abstract The prevalence of urinary stone disease (USD) is rapidly rising. However, the factors driving this increase are unknown. Recent microbiome studies suggest that dysbiosis may in part contribute to the increasing prevalence. The objective of the current study was to determine the nature and location of dysbiosis associated with USD. We conducted microbiome analysis from the gastrointestinal and urinary tracts, along with a metabolomic analysis of the urinary metabolome, from subjects with an active episode of USD or no history of the disease. Higher rates of antibiotic use among USD patients along with integrated microbiome and metabolomic results support the hypothesis that USD is associated with an antibiotic-driven shift in the microbiome from one that protects against USD to one that promotes the disease. Specifically, our study implicates urinary tract Lactobacillus and Enterobacteriaceae in protective and pathogenic roles for USD, respectively, which conventional, culture-based methods of bacterial analysis from urine and kidney stones would not necessarily detect. Results suggest that antibiotics produce a long-term shift in the microbiome that may increase the risk for USD, with the urinary tract microbiome holding more relevance for USD than the gut microbiome.
format	article
author	Anna Zampini Andrew H. Nguyen Emily Rose Manoj Monga Aaron W. Miller
author_facet	Anna Zampini Andrew H. Nguyen Emily Rose Manoj Monga Aaron W. Miller
author_sort	Anna Zampini
title	Defining Dysbiosis in Patients with Urolithiasis
title_short	Defining Dysbiosis in Patients with Urolithiasis
title_full	Defining Dysbiosis in Patients with Urolithiasis
title_fullStr	Defining Dysbiosis in Patients with Urolithiasis
title_full_unstemmed	Defining Dysbiosis in Patients with Urolithiasis
title_sort	defining dysbiosis in patients with urolithiasis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4965c2a35cb1470c8dcf88bc26c366de
work_keys_str_mv	AT annazampini definingdysbiosisinpatientswithurolithiasis AT andrewhnguyen definingdysbiosisinpatientswithurolithiasis AT emilyrose definingdysbiosisinpatientswithurolithiasis AT manojmonga definingdysbiosisinpatientswithurolithiasis AT aaronwmiller definingdysbiosisinpatientswithurolithiasis
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Defining Dysbiosis in Patients with Urolithiasis

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