Increased peripheral blood inflammatory cytokine levels in amyotrophic lateral sclerosis: a meta-analysis study

Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with poorly understood etiology. Increasing evidence suggest that inflammation may play a critical role in the pathogenesis of ALS. Several studies have demonstrated altered levels of blood cytokines in ALS, but result...

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Autores principales:	Yang Hu, Chang Cao, Xiao-Yan Qin, Yun Yu, Jing Yuan, Yu Zhao, Yong Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4974a8631b214120b4e7e6181280e315
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spelling	oai:doaj.org-article:4974a8631b214120b4e7e6181280e3152021-12-02T12:32:18ZIncreased peripheral blood inflammatory cytokine levels in amyotrophic lateral sclerosis: a meta-analysis study10.1038/s41598-017-09097-12045-2322https://doaj.org/article/4974a8631b214120b4e7e6181280e3152017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09097-1https://doaj.org/toc/2045-2322Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with poorly understood etiology. Increasing evidence suggest that inflammation may play a critical role in the pathogenesis of ALS. Several studies have demonstrated altered levels of blood cytokines in ALS, but results were inconsistent. Therefore, we did a systematic review of studies comparing blood inflammatory cytokines between ALS patients and control subjects, and quantitatively combined the clinical data with a meta-analysis. The systematic review of Pubmed and Web of Science identified 25 studies encompassing 812 ALS patients and 639 control subjects. Random-effects meta-analysis demonstrated that blood tumor necrosis factor-α (TNF; Hedges’ g = 0.655; p = 0.001), TNF receptor 1 (Hedges’ g = 0.741; p < 0.001), interleukin 6 (IL-6; Hedges’ g = 0.25; p = 0.005), IL-1β (Hedges’ g = 0.296; p = 0.038), IL-8 (Hedges’ g = 0.449; p < 0.001) and vascular endothelial growth factor (Hedges’ g = 0.891; p = 0.003) levels were significantly elevated in patients with ALS compared with control subjects. These results substantially enhance our knowledge of the inflammatory response in ALS, and peripheral blood inflammatory cytokines may be used as diagnostic biomarkers for ALS in the future.Yang HuChang CaoXiao-Yan QinYun YuJing YuanYu ZhaoYong ChengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yang Hu Chang Cao Xiao-Yan Qin Yun Yu Jing Yuan Yu Zhao Yong Cheng Increased peripheral blood inflammatory cytokine levels in amyotrophic lateral sclerosis: a meta-analysis study
description	Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with poorly understood etiology. Increasing evidence suggest that inflammation may play a critical role in the pathogenesis of ALS. Several studies have demonstrated altered levels of blood cytokines in ALS, but results were inconsistent. Therefore, we did a systematic review of studies comparing blood inflammatory cytokines between ALS patients and control subjects, and quantitatively combined the clinical data with a meta-analysis. The systematic review of Pubmed and Web of Science identified 25 studies encompassing 812 ALS patients and 639 control subjects. Random-effects meta-analysis demonstrated that blood tumor necrosis factor-α (TNF; Hedges’ g = 0.655; p = 0.001), TNF receptor 1 (Hedges’ g = 0.741; p < 0.001), interleukin 6 (IL-6; Hedges’ g = 0.25; p = 0.005), IL-1β (Hedges’ g = 0.296; p = 0.038), IL-8 (Hedges’ g = 0.449; p < 0.001) and vascular endothelial growth factor (Hedges’ g = 0.891; p = 0.003) levels were significantly elevated in patients with ALS compared with control subjects. These results substantially enhance our knowledge of the inflammatory response in ALS, and peripheral blood inflammatory cytokines may be used as diagnostic biomarkers for ALS in the future.
format	article
author	Yang Hu Chang Cao Xiao-Yan Qin Yun Yu Jing Yuan Yu Zhao Yong Cheng
author_facet	Yang Hu Chang Cao Xiao-Yan Qin Yun Yu Jing Yuan Yu Zhao Yong Cheng
author_sort	Yang Hu
title	Increased peripheral blood inflammatory cytokine levels in amyotrophic lateral sclerosis: a meta-analysis study
title_short	Increased peripheral blood inflammatory cytokine levels in amyotrophic lateral sclerosis: a meta-analysis study
title_full	Increased peripheral blood inflammatory cytokine levels in amyotrophic lateral sclerosis: a meta-analysis study
title_fullStr	Increased peripheral blood inflammatory cytokine levels in amyotrophic lateral sclerosis: a meta-analysis study
title_full_unstemmed	Increased peripheral blood inflammatory cytokine levels in amyotrophic lateral sclerosis: a meta-analysis study
title_sort	increased peripheral blood inflammatory cytokine levels in amyotrophic lateral sclerosis: a meta-analysis study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4974a8631b214120b4e7e6181280e315
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Increased peripheral blood inflammatory cytokine levels in amyotrophic lateral sclerosis: a meta-analysis study

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