The gut microbiome in pancreatogenic diabetes differs from that of Type 1 and Type 2 diabetes

Abstract We hypothesized that the gut microbiome in patients with diabetes secondary to chronic pancreatitis (Type 3c) is different from those with Type 1 and Type 2 diabetes. This was a cross-sectional preliminary study that included 8 patients with Type 1, 10 with Type 2, 17 with Type 3c diabetes...

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Autores principales:	Rupjyoti Talukdar, Priyanka Sarkar, Aparna Jakkampudi, Subhaleena Sarkar, Mohsin Aslam, Manasa Jandhyala, G. Deepika, Misbah Unnisa, D. Nageshwar Reddy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4975731e1545469e869a69b2e344eccd
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spelling	oai:doaj.org-article:4975731e1545469e869a69b2e344eccd2021-12-02T14:42:01ZThe gut microbiome in pancreatogenic diabetes differs from that of Type 1 and Type 2 diabetes10.1038/s41598-021-90024-w2045-2322https://doaj.org/article/4975731e1545469e869a69b2e344eccd2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90024-whttps://doaj.org/toc/2045-2322Abstract We hypothesized that the gut microbiome in patients with diabetes secondary to chronic pancreatitis (Type 3c) is different from those with Type 1 and Type 2 diabetes. This was a cross-sectional preliminary study that included 8 patients with Type 1, 10 with Type 2, 17 with Type 3c diabetes and 9 healthy controls. Demographic, clinical, biochemical, imaging and treatment data were recorded and sequencing of the V3–V4 region of the bacterial 16SrRNA was done on fecal samples. Bioinformatics and statistical analyses was performed to evaluate the differences in the diversity indices, distance matrices, relative abundances and uniqueness of organisms between the types of diabetes. There was significant difference in the species richness. Beta diversity was significantly different between patients with Type 3c diabetes and the other groups. 31 genera were common to all the three types of diabetes. There was significant differences in the species level taxa between Type 3c diabetes and the other groups. The unique bacterial species signature in Type 3c diabetes compared to Type 1 and Type 2 diabetes included Nesterenkonia sp. AN1, Clostridium magnum, Acinetobacter lwoffii, Clostridium septicum, Porphyromonas somerae, Terrabacter tumescens, and Synechococus sp.Rupjyoti TalukdarPriyanka SarkarAparna JakkampudiSubhaleena SarkarMohsin AslamManasa JandhyalaG. DeepikaMisbah UnnisaD. Nageshwar ReddyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rupjyoti Talukdar Priyanka Sarkar Aparna Jakkampudi Subhaleena Sarkar Mohsin Aslam Manasa Jandhyala G. Deepika Misbah Unnisa D. Nageshwar Reddy The gut microbiome in pancreatogenic diabetes differs from that of Type 1 and Type 2 diabetes
description	Abstract We hypothesized that the gut microbiome in patients with diabetes secondary to chronic pancreatitis (Type 3c) is different from those with Type 1 and Type 2 diabetes. This was a cross-sectional preliminary study that included 8 patients with Type 1, 10 with Type 2, 17 with Type 3c diabetes and 9 healthy controls. Demographic, clinical, biochemical, imaging and treatment data were recorded and sequencing of the V3–V4 region of the bacterial 16SrRNA was done on fecal samples. Bioinformatics and statistical analyses was performed to evaluate the differences in the diversity indices, distance matrices, relative abundances and uniqueness of organisms between the types of diabetes. There was significant difference in the species richness. Beta diversity was significantly different between patients with Type 3c diabetes and the other groups. 31 genera were common to all the three types of diabetes. There was significant differences in the species level taxa between Type 3c diabetes and the other groups. The unique bacterial species signature in Type 3c diabetes compared to Type 1 and Type 2 diabetes included Nesterenkonia sp. AN1, Clostridium magnum, Acinetobacter lwoffii, Clostridium septicum, Porphyromonas somerae, Terrabacter tumescens, and Synechococus sp.
format	article
author	Rupjyoti Talukdar Priyanka Sarkar Aparna Jakkampudi Subhaleena Sarkar Mohsin Aslam Manasa Jandhyala G. Deepika Misbah Unnisa D. Nageshwar Reddy
author_facet	Rupjyoti Talukdar Priyanka Sarkar Aparna Jakkampudi Subhaleena Sarkar Mohsin Aslam Manasa Jandhyala G. Deepika Misbah Unnisa D. Nageshwar Reddy
author_sort	Rupjyoti Talukdar
title	The gut microbiome in pancreatogenic diabetes differs from that of Type 1 and Type 2 diabetes
title_short	The gut microbiome in pancreatogenic diabetes differs from that of Type 1 and Type 2 diabetes
title_full	The gut microbiome in pancreatogenic diabetes differs from that of Type 1 and Type 2 diabetes
title_fullStr	The gut microbiome in pancreatogenic diabetes differs from that of Type 1 and Type 2 diabetes
title_full_unstemmed	The gut microbiome in pancreatogenic diabetes differs from that of Type 1 and Type 2 diabetes
title_sort	gut microbiome in pancreatogenic diabetes differs from that of type 1 and type 2 diabetes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4975731e1545469e869a69b2e344eccd
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The gut microbiome in pancreatogenic diabetes differs from that of Type 1 and Type 2 diabetes

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