Piperacillin/tazobactam resistance in a clinical isolate of Escherichia coli due to IS26-mediated amplification of bla TEM-1B

An E. coli and K. pneumoniae phenotype resistant to piperacillin/tazobactam has recently emerged. Here, the authors show that hyperproduction of the β-lactamase driving this resistance occurs due to excision and reinsertion of a translocatable unit containing bla TEM-1B, creating a tandem array.

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Autores principales:	Alasdair T. M. Hubbard, Jenifer Mason, Paul Roberts, Christopher M. Parry, Caroline Corless, Jon van Aartsen, Alex Howard, Issra Bulgasim, Alice J. Fraser, Emily R. Adams, Adam P. Roberts, Thomas Edwards
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/49781534e05f4b11946b910dc6606509
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spelling	oai:doaj.org-article:49781534e05f4b11946b910dc66065092021-12-02T18:51:09ZPiperacillin/tazobactam resistance in a clinical isolate of Escherichia coli due to IS26-mediated amplification of bla TEM-1B10.1038/s41467-020-18668-22041-1723https://doaj.org/article/49781534e05f4b11946b910dc66065092020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18668-2https://doaj.org/toc/2041-1723An E. coli and K. pneumoniae phenotype resistant to piperacillin/tazobactam has recently emerged. Here, the authors show that hyperproduction of the β-lactamase driving this resistance occurs due to excision and reinsertion of a translocatable unit containing bla TEM-1B, creating a tandem array.Alasdair T. M. HubbardJenifer MasonPaul RobertsChristopher M. ParryCaroline CorlessJon van AartsenAlex HowardIssra BulgasimAlice J. FraserEmily R. AdamsAdam P. RobertsThomas EdwardsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alasdair T. M. Hubbard Jenifer Mason Paul Roberts Christopher M. Parry Caroline Corless Jon van Aartsen Alex Howard Issra Bulgasim Alice J. Fraser Emily R. Adams Adam P. Roberts Thomas Edwards Piperacillin/tazobactam resistance in a clinical isolate of Escherichia coli due to IS26-mediated amplification of bla TEM-1B
description	An E. coli and K. pneumoniae phenotype resistant to piperacillin/tazobactam has recently emerged. Here, the authors show that hyperproduction of the β-lactamase driving this resistance occurs due to excision and reinsertion of a translocatable unit containing bla TEM-1B, creating a tandem array.
format	article
author	Alasdair T. M. Hubbard Jenifer Mason Paul Roberts Christopher M. Parry Caroline Corless Jon van Aartsen Alex Howard Issra Bulgasim Alice J. Fraser Emily R. Adams Adam P. Roberts Thomas Edwards
author_facet	Alasdair T. M. Hubbard Jenifer Mason Paul Roberts Christopher M. Parry Caroline Corless Jon van Aartsen Alex Howard Issra Bulgasim Alice J. Fraser Emily R. Adams Adam P. Roberts Thomas Edwards
author_sort	Alasdair T. M. Hubbard
title	Piperacillin/tazobactam resistance in a clinical isolate of Escherichia coli due to IS26-mediated amplification of bla TEM-1B
title_short	Piperacillin/tazobactam resistance in a clinical isolate of Escherichia coli due to IS26-mediated amplification of bla TEM-1B
title_full	Piperacillin/tazobactam resistance in a clinical isolate of Escherichia coli due to IS26-mediated amplification of bla TEM-1B
title_fullStr	Piperacillin/tazobactam resistance in a clinical isolate of Escherichia coli due to IS26-mediated amplification of bla TEM-1B
title_full_unstemmed	Piperacillin/tazobactam resistance in a clinical isolate of Escherichia coli due to IS26-mediated amplification of bla TEM-1B
title_sort	piperacillin/tazobactam resistance in a clinical isolate of escherichia coli due to is26-mediated amplification of bla tem-1b
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/49781534e05f4b11946b910dc6606509
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Piperacillin/tazobactam resistance in a clinical isolate of Escherichia coli due to IS26-mediated amplification of bla TEM-1B

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