Small-diameter hybrid vascular grafts composed of polycaprolactone and polydioxanone fibers

Abstract Electrospun polycaprolactone (PCL) vascular grafts showed good mechanical properties and patency. However, the slow degradation of PCL limited vascular regeneration in the graft. Polydioxanone (PDS) is a biodegradable polymer with high mechanical strength and moderate degradation rate in vi...

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Autores principales:	Yiwa Pan, Xin Zhou, Yongzhen Wei, Qiuying Zhang, Ting Wang, Meifeng Zhu, Wen Li, Rui Huang, Ruming Liu, Jingrui Chen, Guanwei Fan, Kai Wang, Deling Kong, Qiang Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/497b9624a44d4061a993bfb8d568c2c7
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spelling	oai:doaj.org-article:497b9624a44d4061a993bfb8d568c2c72021-12-02T11:52:31ZSmall-diameter hybrid vascular grafts composed of polycaprolactone and polydioxanone fibers10.1038/s41598-017-03851-12045-2322https://doaj.org/article/497b9624a44d4061a993bfb8d568c2c72017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03851-1https://doaj.org/toc/2045-2322Abstract Electrospun polycaprolactone (PCL) vascular grafts showed good mechanical properties and patency. However, the slow degradation of PCL limited vascular regeneration in the graft. Polydioxanone (PDS) is a biodegradable polymer with high mechanical strength and moderate degradation rate in vivo. In this study, a small-diameter hybrid vascular graft was prepared by co-electrospinning PCL and PDS fibers. The incorporation of PDS improves mechanical properties, hydrophilicity of the hybrid grafts compared to PCL grafts. The in vitro/vivo degradation assay showed that PDS fibers completely degraded within 12 weeks, which resulted in the increased pore size of PCL/PDS grafts. The healing characteristics of the hybrid grafts were evaluated by implantation in rat abdominal aorta replacement model for 1 and 3 months. Color Doppler ultrasound demonstrated PCL/PDS grafts had good patency, and did not show aneurysmal dilatation. Immunofluorescence staining showed the coverage of endothelial cells (ECs) was significantly enhanced in PCL/PDS grafts due to the improved surface hydrophilicity. The degradation of PDS fibers provided extra space, which facilitated vascular smooth muscle regeneration within PCL/PDS grafts. These results suggest that the hybrid PCL/PDS graft may be a promising candidate for the small-diameter vascular grafts.Yiwa PanXin ZhouYongzhen WeiQiuying ZhangTing WangMeifeng ZhuWen LiRui HuangRuming LiuJingrui ChenGuanwei FanKai WangDeling KongQiang ZhaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yiwa Pan Xin Zhou Yongzhen Wei Qiuying Zhang Ting Wang Meifeng Zhu Wen Li Rui Huang Ruming Liu Jingrui Chen Guanwei Fan Kai Wang Deling Kong Qiang Zhao Small-diameter hybrid vascular grafts composed of polycaprolactone and polydioxanone fibers
description	Abstract Electrospun polycaprolactone (PCL) vascular grafts showed good mechanical properties and patency. However, the slow degradation of PCL limited vascular regeneration in the graft. Polydioxanone (PDS) is a biodegradable polymer with high mechanical strength and moderate degradation rate in vivo. In this study, a small-diameter hybrid vascular graft was prepared by co-electrospinning PCL and PDS fibers. The incorporation of PDS improves mechanical properties, hydrophilicity of the hybrid grafts compared to PCL grafts. The in vitro/vivo degradation assay showed that PDS fibers completely degraded within 12 weeks, which resulted in the increased pore size of PCL/PDS grafts. The healing characteristics of the hybrid grafts were evaluated by implantation in rat abdominal aorta replacement model for 1 and 3 months. Color Doppler ultrasound demonstrated PCL/PDS grafts had good patency, and did not show aneurysmal dilatation. Immunofluorescence staining showed the coverage of endothelial cells (ECs) was significantly enhanced in PCL/PDS grafts due to the improved surface hydrophilicity. The degradation of PDS fibers provided extra space, which facilitated vascular smooth muscle regeneration within PCL/PDS grafts. These results suggest that the hybrid PCL/PDS graft may be a promising candidate for the small-diameter vascular grafts.
format	article
author	Yiwa Pan Xin Zhou Yongzhen Wei Qiuying Zhang Ting Wang Meifeng Zhu Wen Li Rui Huang Ruming Liu Jingrui Chen Guanwei Fan Kai Wang Deling Kong Qiang Zhao
author_facet	Yiwa Pan Xin Zhou Yongzhen Wei Qiuying Zhang Ting Wang Meifeng Zhu Wen Li Rui Huang Ruming Liu Jingrui Chen Guanwei Fan Kai Wang Deling Kong Qiang Zhao
author_sort	Yiwa Pan
title	Small-diameter hybrid vascular grafts composed of polycaprolactone and polydioxanone fibers
title_short	Small-diameter hybrid vascular grafts composed of polycaprolactone and polydioxanone fibers
title_full	Small-diameter hybrid vascular grafts composed of polycaprolactone and polydioxanone fibers
title_fullStr	Small-diameter hybrid vascular grafts composed of polycaprolactone and polydioxanone fibers
title_full_unstemmed	Small-diameter hybrid vascular grafts composed of polycaprolactone and polydioxanone fibers
title_sort	small-diameter hybrid vascular grafts composed of polycaprolactone and polydioxanone fibers
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/497b9624a44d4061a993bfb8d568c2c7
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Small-diameter hybrid vascular grafts composed of polycaprolactone and polydioxanone fibers

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