TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity

Yu et al examined a panel of both experimental and clinically-relevant TNF agonists in order to advance our understanding of the mechanisms underlying their varying activities and anti-tumor responses. They demonstrated that agonists with greater activity induced higher density receptor clustering a...

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Autores principales:	Xiaojie Yu, Sonya James, James H. Felce, Blanka Kellermayer, David A. Johnston, H. T. Claude Chan, Christine A. Penfold, Jinny Kim, Tatyana Inzhelevskaya, C. Ian Mockridge, Yasunori Watanabe, Max Crispin, Ruth R. French, Patrick J. Duriez, Leon R. Douglas, Martin J. Glennie, Mark S. Cragg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/497b996aa1574d6a946f5ee6787fec3f
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spelling	oai:doaj.org-article:497b996aa1574d6a946f5ee6787fec3f2021-12-02T17:44:53ZTNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity10.1038/s42003-021-02309-52399-3642https://doaj.org/article/497b996aa1574d6a946f5ee6787fec3f2021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02309-5https://doaj.org/toc/2399-3642Yu et al examined a panel of both experimental and clinically-relevant TNF agonists in order to advance our understanding of the mechanisms underlying their varying activities and anti-tumor responses. They demonstrated that agonists with greater activity induced higher density receptor clustering and specific super-structures as opposed to simply larger receptor clusters.Xiaojie YuSonya JamesJames H. FelceBlanka KellermayerDavid A. JohnstonH. T. Claude ChanChristine A. PenfoldJinny KimTatyana InzhelevskayaC. Ian MockridgeYasunori WatanabeMax CrispinRuth R. FrenchPatrick J. DuriezLeon R. DouglasMartin J. GlennieMark S. CraggNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Xiaojie Yu Sonya James James H. Felce Blanka Kellermayer David A. Johnston H. T. Claude Chan Christine A. Penfold Jinny Kim Tatyana Inzhelevskaya C. Ian Mockridge Yasunori Watanabe Max Crispin Ruth R. French Patrick J. Duriez Leon R. Douglas Martin J. Glennie Mark S. Cragg TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity
description	Yu et al examined a panel of both experimental and clinically-relevant TNF agonists in order to advance our understanding of the mechanisms underlying their varying activities and anti-tumor responses. They demonstrated that agonists with greater activity induced higher density receptor clustering and specific super-structures as opposed to simply larger receptor clusters.
format	article
author	Xiaojie Yu Sonya James James H. Felce Blanka Kellermayer David A. Johnston H. T. Claude Chan Christine A. Penfold Jinny Kim Tatyana Inzhelevskaya C. Ian Mockridge Yasunori Watanabe Max Crispin Ruth R. French Patrick J. Duriez Leon R. Douglas Martin J. Glennie Mark S. Cragg
author_facet	Xiaojie Yu Sonya James James H. Felce Blanka Kellermayer David A. Johnston H. T. Claude Chan Christine A. Penfold Jinny Kim Tatyana Inzhelevskaya C. Ian Mockridge Yasunori Watanabe Max Crispin Ruth R. French Patrick J. Duriez Leon R. Douglas Martin J. Glennie Mark S. Cragg
author_sort	Xiaojie Yu
title	TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity
title_short	TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity
title_full	TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity
title_fullStr	TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity
title_full_unstemmed	TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity
title_sort	tnf receptor agonists induce distinct receptor clusters to mediate differential agonistic activity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/497b996aa1574d6a946f5ee6787fec3f
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TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity

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