Decreased thalamo-cortico connectivity during an implicit sequence motor learning task and 7 days escitalopram intake

Abstract Evidence suggests that selective serotonin reuptake inhibitors (SSRIs) reorganize neural networks via a transient window of neuroplasticity. While previous findings support an effect of SSRIs on intrinsic functional connectivity, little is known regarding the influence of SSRI-administratio...

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Autores principales:	Eóin N. Molloy, Rachel G. Zsido, Fabian A. Piecha, Nathalie Beinhölzl, Ulrike Scharrer, Gergana Zheleva, Ralf Regenthal, Bernhard Sehm, Vadim V. Nikulin, Harald E. Möller, Arno Villringer, Julia Sacher, Karsten Mueller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/497ba8eef4c048129b93f28aba6b5594
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spelling	oai:doaj.org-article:497ba8eef4c048129b93f28aba6b55942021-12-02T16:26:37ZDecreased thalamo-cortico connectivity during an implicit sequence motor learning task and 7 days escitalopram intake10.1038/s41598-021-94009-72045-2322https://doaj.org/article/497ba8eef4c048129b93f28aba6b55942021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94009-7https://doaj.org/toc/2045-2322Abstract Evidence suggests that selective serotonin reuptake inhibitors (SSRIs) reorganize neural networks via a transient window of neuroplasticity. While previous findings support an effect of SSRIs on intrinsic functional connectivity, little is known regarding the influence of SSRI-administration on connectivity during sequence motor learning. To investigate this, we administered 20 mg escitalopram or placebo for 1-week to 60 healthy female participants undergoing concurrent functional magnetic resonance imaging and sequence motor training in a double-blind randomized controlled design. We assessed task-modulated functional connectivity with a psycho-physiological interaction (PPI) analysis in the thalamus, putamen, cerebellum, dorsal premotor, primary motor, supplementary motor, and dorsolateral prefrontal cortices. Comparing an implicit sequence learning condition to a control learning condition, we observed decreased connectivity between the thalamus and bilateral motor regions after 7 days of escitalopram intake. Additionally, we observed a negative correlation between plasma escitalopram levels and PPI connectivity changes, with higher escitalopram levels being associated with greater thalamo-cortico decreases. Our results suggest that escitalopram enhances network-level processing efficiency during sequence motor learning, despite no changes in behaviour. Future studies in more diverse samples, however, with quantitative imaging of neurochemical markers of excitation and inhibition, are necessary to further assess neural responses to escitalopram.Eóin N. MolloyRachel G. ZsidoFabian A. PiechaNathalie BeinhölzlUlrike ScharrerGergana ZhelevaRalf RegenthalBernhard SehmVadim V. NikulinHarald E. MöllerArno VillringerJulia SacherKarsten MuellerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eóin N. Molloy Rachel G. Zsido Fabian A. Piecha Nathalie Beinhölzl Ulrike Scharrer Gergana Zheleva Ralf Regenthal Bernhard Sehm Vadim V. Nikulin Harald E. Möller Arno Villringer Julia Sacher Karsten Mueller Decreased thalamo-cortico connectivity during an implicit sequence motor learning task and 7 days escitalopram intake
description	Abstract Evidence suggests that selective serotonin reuptake inhibitors (SSRIs) reorganize neural networks via a transient window of neuroplasticity. While previous findings support an effect of SSRIs on intrinsic functional connectivity, little is known regarding the influence of SSRI-administration on connectivity during sequence motor learning. To investigate this, we administered 20 mg escitalopram or placebo for 1-week to 60 healthy female participants undergoing concurrent functional magnetic resonance imaging and sequence motor training in a double-blind randomized controlled design. We assessed task-modulated functional connectivity with a psycho-physiological interaction (PPI) analysis in the thalamus, putamen, cerebellum, dorsal premotor, primary motor, supplementary motor, and dorsolateral prefrontal cortices. Comparing an implicit sequence learning condition to a control learning condition, we observed decreased connectivity between the thalamus and bilateral motor regions after 7 days of escitalopram intake. Additionally, we observed a negative correlation between plasma escitalopram levels and PPI connectivity changes, with higher escitalopram levels being associated with greater thalamo-cortico decreases. Our results suggest that escitalopram enhances network-level processing efficiency during sequence motor learning, despite no changes in behaviour. Future studies in more diverse samples, however, with quantitative imaging of neurochemical markers of excitation and inhibition, are necessary to further assess neural responses to escitalopram.
format	article
author	Eóin N. Molloy Rachel G. Zsido Fabian A. Piecha Nathalie Beinhölzl Ulrike Scharrer Gergana Zheleva Ralf Regenthal Bernhard Sehm Vadim V. Nikulin Harald E. Möller Arno Villringer Julia Sacher Karsten Mueller
author_facet	Eóin N. Molloy Rachel G. Zsido Fabian A. Piecha Nathalie Beinhölzl Ulrike Scharrer Gergana Zheleva Ralf Regenthal Bernhard Sehm Vadim V. Nikulin Harald E. Möller Arno Villringer Julia Sacher Karsten Mueller
author_sort	Eóin N. Molloy
title	Decreased thalamo-cortico connectivity during an implicit sequence motor learning task and 7 days escitalopram intake
title_short	Decreased thalamo-cortico connectivity during an implicit sequence motor learning task and 7 days escitalopram intake
title_full	Decreased thalamo-cortico connectivity during an implicit sequence motor learning task and 7 days escitalopram intake
title_fullStr	Decreased thalamo-cortico connectivity during an implicit sequence motor learning task and 7 days escitalopram intake
title_full_unstemmed	Decreased thalamo-cortico connectivity during an implicit sequence motor learning task and 7 days escitalopram intake
title_sort	decreased thalamo-cortico connectivity during an implicit sequence motor learning task and 7 days escitalopram intake
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/497ba8eef4c048129b93f28aba6b5594
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Decreased thalamo-cortico connectivity during an implicit sequence motor learning task and 7 days escitalopram intake

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