Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP

Several metabolic factors affect cellular glucose metabolism as well as the innate inflammatory response. Here, the authors show that glucose metabolism regulates pro-inflammatory responses through effects on the cytosolic NADH:NAD+ ratio and the NAD(H)-sensitive transcription co-repressor CtBP.

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Autores principales:	Yiguo Shen, David Kapfhamer, Angela M. Minnella, Ji-Eun Kim, Seok Joon Won, Yanting Chen, Yong Huang, Ley Hian Low, Stephen M. Massa, Raymond A. Swanson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/497cdfb0e4284c52930bb8c6a8bbcb88
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spelling	oai:doaj.org-article:497cdfb0e4284c52930bb8c6a8bbcb882021-12-02T14:42:50ZBioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP10.1038/s41467-017-00707-02041-1723https://doaj.org/article/497cdfb0e4284c52930bb8c6a8bbcb882017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00707-0https://doaj.org/toc/2041-1723Several metabolic factors affect cellular glucose metabolism as well as the innate inflammatory response. Here, the authors show that glucose metabolism regulates pro-inflammatory responses through effects on the cytosolic NADH:NAD+ ratio and the NAD(H)-sensitive transcription co-repressor CtBP.Yiguo ShenDavid KapfhamerAngela M. MinnellaJi-Eun KimSeok Joon WonYanting ChenYong HuangLey Hian LowStephen M. MassaRaymond A. SwansonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yiguo Shen David Kapfhamer Angela M. Minnella Ji-Eun Kim Seok Joon Won Yanting Chen Yong Huang Ley Hian Low Stephen M. Massa Raymond A. Swanson Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP
description	Several metabolic factors affect cellular glucose metabolism as well as the innate inflammatory response. Here, the authors show that glucose metabolism regulates pro-inflammatory responses through effects on the cytosolic NADH:NAD+ ratio and the NAD(H)-sensitive transcription co-repressor CtBP.
format	article
author	Yiguo Shen David Kapfhamer Angela M. Minnella Ji-Eun Kim Seok Joon Won Yanting Chen Yong Huang Ley Hian Low Stephen M. Massa Raymond A. Swanson
author_facet	Yiguo Shen David Kapfhamer Angela M. Minnella Ji-Eun Kim Seok Joon Won Yanting Chen Yong Huang Ley Hian Low Stephen M. Massa Raymond A. Swanson
author_sort	Yiguo Shen
title	Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP
title_short	Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP
title_full	Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP
title_fullStr	Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP
title_full_unstemmed	Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP
title_sort	bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor ctbp
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/497cdfb0e4284c52930bb8c6a8bbcb88
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Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP

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