Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer

Histone methyltransferase, DOTL1 is implicated in the pathogenesis of MLL-rearranged leukemia, however, not much is known of its role in prostate cancer (PCa). Here, the authors report that DOTL1 inhibition suppresses both androgen receptor and MYC pathways in a negative feed forward manner to reduc...

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Autores principales:	R. Vatapalli, V. Sagar, Y. Rodriguez, J. C. Zhao, K. Unno, S. Pamarthy, B. Lysy, J. Anker, H. Han, Y. A. Yoo, M. Truica, Z. R. Chalmers, F. Giles, J. Yu, D. Chakravarti, B. Carneiro, S. A. Abdulkadir
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/497ddec128fb4766b74876d35775416b
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spelling	oai:doaj.org-article:497ddec128fb4766b74876d35775416b2021-12-02T18:00:09ZHistone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer10.1038/s41467-020-18013-72041-1723https://doaj.org/article/497ddec128fb4766b74876d35775416b2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18013-7https://doaj.org/toc/2041-1723Histone methyltransferase, DOTL1 is implicated in the pathogenesis of MLL-rearranged leukemia, however, not much is known of its role in prostate cancer (PCa). Here, the authors report that DOTL1 inhibition suppresses both androgen receptor and MYC pathways in a negative feed forward manner to reduce growth of AR-positive PCa.R. VatapalliV. SagarY. RodriguezJ. C. ZhaoK. UnnoS. PamarthyB. LysyJ. AnkerH. HanY. A. YooM. TruicaZ. R. ChalmersF. GilesJ. YuD. ChakravartiB. CarneiroS. A. AbdulkadirNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q R. Vatapalli V. Sagar Y. Rodriguez J. C. Zhao K. Unno S. Pamarthy B. Lysy J. Anker H. Han Y. A. Yoo M. Truica Z. R. Chalmers F. Giles J. Yu D. Chakravarti B. Carneiro S. A. Abdulkadir Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer
description	Histone methyltransferase, DOTL1 is implicated in the pathogenesis of MLL-rearranged leukemia, however, not much is known of its role in prostate cancer (PCa). Here, the authors report that DOTL1 inhibition suppresses both androgen receptor and MYC pathways in a negative feed forward manner to reduce growth of AR-positive PCa.
format	article
author	R. Vatapalli V. Sagar Y. Rodriguez J. C. Zhao K. Unno S. Pamarthy B. Lysy J. Anker H. Han Y. A. Yoo M. Truica Z. R. Chalmers F. Giles J. Yu D. Chakravarti B. Carneiro S. A. Abdulkadir
author_facet	R. Vatapalli V. Sagar Y. Rodriguez J. C. Zhao K. Unno S. Pamarthy B. Lysy J. Anker H. Han Y. A. Yoo M. Truica Z. R. Chalmers F. Giles J. Yu D. Chakravarti B. Carneiro S. A. Abdulkadir
author_sort	R. Vatapalli
title	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer
title_short	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer
title_full	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer
title_fullStr	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer
title_full_unstemmed	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer
title_sort	histone methyltransferase dot1l coordinates ar and myc stability in prostate cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/497ddec128fb4766b74876d35775416b
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Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer

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