Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer
Histone methyltransferase, DOTL1 is implicated in the pathogenesis of MLL-rearranged leukemia, however, not much is known of its role in prostate cancer (PCa). Here, the authors report that DOTL1 inhibition suppresses both androgen receptor and MYC pathways in a negative feed forward manner to reduc...
Guardado en:
Autores principales: | R. Vatapalli, V. Sagar, Y. Rodriguez, J. C. Zhao, K. Unno, S. Pamarthy, B. Lysy, J. Anker, H. Han, Y. A. Yoo, M. Truica, Z. R. Chalmers, F. Giles, J. Yu, D. Chakravarti, B. Carneiro, S. A. Abdulkadir |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/497ddec128fb4766b74876d35775416b |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
A histone methyltransferase modulates antigenic variation in African trypanosomes.
por: Luisa M Figueiredo, et al.
Publicado: (2008) -
Regulation of the DNA damage response and gene expression by the Dot1L histone methyltransferase and the 53Bp1 tumour suppressor.
por: Jennifer FitzGerald, et al.
Publicado: (2011) -
Fine-tuning of lysine side chain modulates the activity of histone lysine methyltransferases
por: Abbas H. K. Al Temimi, et al.
Publicado: (2020) -
Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation
por: Jie Zhou, et al.
Publicado: (2019) -
Structural and functional profiling of the human histone methyltransferase SMYD3.
por: Kenneth W Foreman, et al.
Publicado: (2011)