Neutrophil and Platelet to Lymphocyte Ratio for Detecting Early-onset Neonatal Sepsis

Background: Neonatal sepsis [NS] is associated with severe morbidity and mortality. Clinical manifestations range from subclinical infection to severe local or systemic infection. The diagnosis of NS remains a challenge as it has subtle and distinct signs and symptoms. Although blood culture is the...

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Autores principales:	Sara Mira, Hany Alkhalegy, Sabah Abd-Elraheem, Elbakry Elbakry
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2021
Materias:	neonate early onset sepsis neutrophil lymphocyte ratio platelet lymphocyte ratio Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/497f378849ae46cab2ce634f41afa354
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spelling	oai:doaj.org-article:497f378849ae46cab2ce634f41afa3542021-12-02T15:54:52ZNeutrophil and Platelet to Lymphocyte Ratio for Detecting Early-onset Neonatal Sepsis2636-41742682-378010.21608/ijma.2020.21844.1069https://doaj.org/article/497f378849ae46cab2ce634f41afa3542021-04-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_116302_483e9ebc55b7bcc4e9d708b2a2f772bb.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Neonatal sepsis [NS] is associated with severe morbidity and mortality. Clinical manifestations range from subclinical infection to severe local or systemic infection. The diagnosis of NS remains a challenge as it has subtle and distinct signs and symptoms. Although blood culture is the gold standard in the diagnosis of NS, the search for high-sensitivity NS markers continues to overcome the drawbacks of blood cultures. The aim of the work: This study aimed to investigate the effectiveness of the neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in predicting early onset sepsis in neonates. Patients and Methods: A case control study, comprised 120 newborns [60 newborns with neonatal sepsis as a case group and 60 healthy newborns as a control group], based on patient records at neonatal intensive care unit [NICU] of Al-Azhar University Hospital [Damietta], from January 2018 to January 2019. All were subjected to adequate history taking, full clinical examination, complete blood picture, C-reactive protein and blood culture. After that, neutrophil to lymphocyte ratio [NLR] and platelet to lymphocyte ratio [PLR] were calculated. Results: NLR was significantly higher in neonates with sepsis. However, there were no association between PLR and early onset sepsis [EOS]. Although, the diagnostic cutoff value for NLR was 1.0 with 72% sensitivity, 100% specificity, there was no association between PLR and EOS. Conclusion: NLR increases significantly in neonatal sepsis, and can be used as a marker for detection of early onset neonatal sepsis.Sara MiraHany AlkhalegySabah Abd-ElraheemElbakry ElbakryAl-Azhar University, Faculty of Medicine (Damietta)articleneonateearly onset sepsisneutrophil lymphocyte ratioplatelet lymphocyte ratioMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 3, Iss 2, Pp 1274-1281 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neonate early onset sepsis neutrophil lymphocyte ratio platelet lymphocyte ratio Medicine (General) R5-920
spellingShingle	neonate early onset sepsis neutrophil lymphocyte ratio platelet lymphocyte ratio Medicine (General) R5-920 Sara Mira Hany Alkhalegy Sabah Abd-Elraheem Elbakry Elbakry Neutrophil and Platelet to Lymphocyte Ratio for Detecting Early-onset Neonatal Sepsis
description	Background: Neonatal sepsis [NS] is associated with severe morbidity and mortality. Clinical manifestations range from subclinical infection to severe local or systemic infection. The diagnosis of NS remains a challenge as it has subtle and distinct signs and symptoms. Although blood culture is the gold standard in the diagnosis of NS, the search for high-sensitivity NS markers continues to overcome the drawbacks of blood cultures. The aim of the work: This study aimed to investigate the effectiveness of the neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in predicting early onset sepsis in neonates. Patients and Methods: A case control study, comprised 120 newborns [60 newborns with neonatal sepsis as a case group and 60 healthy newborns as a control group], based on patient records at neonatal intensive care unit [NICU] of Al-Azhar University Hospital [Damietta], from January 2018 to January 2019. All were subjected to adequate history taking, full clinical examination, complete blood picture, C-reactive protein and blood culture. After that, neutrophil to lymphocyte ratio [NLR] and platelet to lymphocyte ratio [PLR] were calculated. Results: NLR was significantly higher in neonates with sepsis. However, there were no association between PLR and early onset sepsis [EOS]. Although, the diagnostic cutoff value for NLR was 1.0 with 72% sensitivity, 100% specificity, there was no association between PLR and EOS. Conclusion: NLR increases significantly in neonatal sepsis, and can be used as a marker for detection of early onset neonatal sepsis.
format	article
author	Sara Mira Hany Alkhalegy Sabah Abd-Elraheem Elbakry Elbakry
author_facet	Sara Mira Hany Alkhalegy Sabah Abd-Elraheem Elbakry Elbakry
author_sort	Sara Mira
title	Neutrophil and Platelet to Lymphocyte Ratio for Detecting Early-onset Neonatal Sepsis
title_short	Neutrophil and Platelet to Lymphocyte Ratio for Detecting Early-onset Neonatal Sepsis
title_full	Neutrophil and Platelet to Lymphocyte Ratio for Detecting Early-onset Neonatal Sepsis
title_fullStr	Neutrophil and Platelet to Lymphocyte Ratio for Detecting Early-onset Neonatal Sepsis
title_full_unstemmed	Neutrophil and Platelet to Lymphocyte Ratio for Detecting Early-onset Neonatal Sepsis
title_sort	neutrophil and platelet to lymphocyte ratio for detecting early-onset neonatal sepsis
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2021
url	https://doaj.org/article/497f378849ae46cab2ce634f41afa354
work_keys_str_mv	AT saramira neutrophilandplatelettolymphocyteratiofordetectingearlyonsetneonatalsepsis AT hanyalkhalegy neutrophilandplatelettolymphocyteratiofordetectingearlyonsetneonatalsepsis AT sabahabdelraheem neutrophilandplatelettolymphocyteratiofordetectingearlyonsetneonatalsepsis AT elbakryelbakry neutrophilandplatelettolymphocyteratiofordetectingearlyonsetneonatalsepsis
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Neutrophil and Platelet to Lymphocyte Ratio for Detecting Early-onset Neonatal Sepsis

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