Fungal lifestyle reflected in serine protease repertoire

Abstract Fungi are able to switch between different lifestyles in order to adapt to environmental changes. Their ecological strategy is connected to their secretome as fungi obtain nutrients by secreting hydrolytic enzymes to their surrounding and acquiring the digested molecules. We focus on fungal...

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Autores principales:	Anna Muszewska, Marta M. Stepniewska-Dziubinska, Kamil Steczkiewicz, Julia Pawlowska, Agata Dziedzic, Krzysztof Ginalski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/498056da17074b239799fc19bf436e0c
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spelling	oai:doaj.org-article:498056da17074b239799fc19bf436e0c2021-12-02T11:52:42ZFungal lifestyle reflected in serine protease repertoire10.1038/s41598-017-09644-w2045-2322https://doaj.org/article/498056da17074b239799fc19bf436e0c2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09644-whttps://doaj.org/toc/2045-2322Abstract Fungi are able to switch between different lifestyles in order to adapt to environmental changes. Their ecological strategy is connected to their secretome as fungi obtain nutrients by secreting hydrolytic enzymes to their surrounding and acquiring the digested molecules. We focus on fungal serine proteases (SPs), the phylogenetic distribution of which is barely described so far. In order to collect a complete set of fungal proteases, we searched over 600 fungal proteomes. Obtained results suggest that serine proteases are more ubiquitous than expected. From 54 SP families described in MEROPS Peptidase Database, 21 are present in fungi. Interestingly, 14 of them are also present in Metazoa and Viridiplantae – this suggests that, except one (S64), all fungal SP families evolved before plants and fungi diverged. Most representatives of sequenced eukaryotic lineages encode a set of 13–16 SP families. The number of SPs from each family varies among the analysed taxa. The most abundant are S8 proteases. In order to verify hypotheses linking lifestyle and expansions of particular SP, we performed statistical analyses and revealed previously undescribed associations. Here, we present a comprehensive evolutionary history of fungal SP families in the context of fungal ecology and fungal tree of life.Anna MuszewskaMarta M. Stepniewska-DziubinskaKamil SteczkiewiczJulia PawlowskaAgata DziedzicKrzysztof GinalskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anna Muszewska Marta M. Stepniewska-Dziubinska Kamil Steczkiewicz Julia Pawlowska Agata Dziedzic Krzysztof Ginalski Fungal lifestyle reflected in serine protease repertoire
description	Abstract Fungi are able to switch between different lifestyles in order to adapt to environmental changes. Their ecological strategy is connected to their secretome as fungi obtain nutrients by secreting hydrolytic enzymes to their surrounding and acquiring the digested molecules. We focus on fungal serine proteases (SPs), the phylogenetic distribution of which is barely described so far. In order to collect a complete set of fungal proteases, we searched over 600 fungal proteomes. Obtained results suggest that serine proteases are more ubiquitous than expected. From 54 SP families described in MEROPS Peptidase Database, 21 are present in fungi. Interestingly, 14 of them are also present in Metazoa and Viridiplantae – this suggests that, except one (S64), all fungal SP families evolved before plants and fungi diverged. Most representatives of sequenced eukaryotic lineages encode a set of 13–16 SP families. The number of SPs from each family varies among the analysed taxa. The most abundant are S8 proteases. In order to verify hypotheses linking lifestyle and expansions of particular SP, we performed statistical analyses and revealed previously undescribed associations. Here, we present a comprehensive evolutionary history of fungal SP families in the context of fungal ecology and fungal tree of life.
format	article
author	Anna Muszewska Marta M. Stepniewska-Dziubinska Kamil Steczkiewicz Julia Pawlowska Agata Dziedzic Krzysztof Ginalski
author_facet	Anna Muszewska Marta M. Stepniewska-Dziubinska Kamil Steczkiewicz Julia Pawlowska Agata Dziedzic Krzysztof Ginalski
author_sort	Anna Muszewska
title	Fungal lifestyle reflected in serine protease repertoire
title_short	Fungal lifestyle reflected in serine protease repertoire
title_full	Fungal lifestyle reflected in serine protease repertoire
title_fullStr	Fungal lifestyle reflected in serine protease repertoire
title_full_unstemmed	Fungal lifestyle reflected in serine protease repertoire
title_sort	fungal lifestyle reflected in serine protease repertoire
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/498056da17074b239799fc19bf436e0c
work_keys_str_mv	AT annamuszewska fungallifestylereflectedinserineproteaserepertoire AT martamstepniewskadziubinska fungallifestylereflectedinserineproteaserepertoire AT kamilsteczkiewicz fungallifestylereflectedinserineproteaserepertoire AT juliapawlowska fungallifestylereflectedinserineproteaserepertoire AT agatadziedzic fungallifestylereflectedinserineproteaserepertoire AT krzysztofginalski fungallifestylereflectedinserineproteaserepertoire
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Fungal lifestyle reflected in serine protease repertoire

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