Associations of HLA-DP variants with hepatitis B virus infection in southern and northern Han Chinese populations: a multicenter case-control study.
<h4>Background</h4>Human leukocyte antigen DP (HLA-DP) locus has been reported to be associated with hepatitis B virus (HBV) infection in populations of Japan and Thailand. We aimed to examine whether the association can be replicated in Han Chinese populations.<h4>Methodology/prin...
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2011
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oai:doaj.org-article:49808f46555a4951a0d02ac63e7e744d2021-11-18T06:46:58ZAssociations of HLA-DP variants with hepatitis B virus infection in southern and northern Han Chinese populations: a multicenter case-control study.1932-620310.1371/journal.pone.0024221https://doaj.org/article/49808f46555a4951a0d02ac63e7e744d2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21904616/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Human leukocyte antigen DP (HLA-DP) locus has been reported to be associated with hepatitis B virus (HBV) infection in populations of Japan and Thailand. We aimed to examine whether the association can be replicated in Han Chinese populations.<h4>Methodology/principal findings</h4>Two HLA-DP variants rs2395309 and rs9277535 (the most strongly associated SNPs from each HLA-DP locus) were genotyped in three independent Han cohorts consisting of 2 805 cases and 1 796 controls. By using logistic regression analysis, these two SNPs in the HLA-DPA1 and HLA-DPB1 genes were significantly associated with HBV infection in Han Chinese populations (P = 0.021∼3.36×10(-8) at rs2395309; P = 8.37×10(-3)∼2.68×10(-10) at rs9277535). In addition, the genotype distributions of both sites (rs2395309 and rs9277535) were clearly different between southern and northern Chinese population (P = 8.95×10(-5) at rs2395309; P = 1.64×10(-9) at rs9277535). By using asymptomatic HBV carrier as control group, our study showed that there were no associations of two HLA-DP variants with HBV progression (P = 0.305∼0.822 and 0.163∼0.881 in southern Chinese population, respectively; P = 0.097∼0.697 and 0.198∼0.615 in northern Chinese population, respectively).<h4>Conclusions</h4>Our results confirmed that two SNPs (rs2395309 and rs9277535) in the HLA-DP loci were strongly associated with HBV infection in southern and northern Han Chinese populations, but not with HBV progression.Jin LiDaguo YangYongwen HeMengyi WangZirong WenLifeng LiuJinjian YaoKoichi MatsudaYusuke NakamuraJinling YuXiaorui JiangShuzhen SunQing LiuXiang JiangQilong SongMan ChenHong YangFeng TangXiaowen HuJing WangYing ChangXingxing HeYuan ChenJusheng LinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 8, p e24221 (2011) |
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Medicine R Science Q Jin Li Daguo Yang Yongwen He Mengyi Wang Zirong Wen Lifeng Liu Jinjian Yao Koichi Matsuda Yusuke Nakamura Jinling Yu Xiaorui Jiang Shuzhen Sun Qing Liu Xiang Jiang Qilong Song Man Chen Hong Yang Feng Tang Xiaowen Hu Jing Wang Ying Chang Xingxing He Yuan Chen Jusheng Lin Associations of HLA-DP variants with hepatitis B virus infection in southern and northern Han Chinese populations: a multicenter case-control study. |
| description |
<h4>Background</h4>Human leukocyte antigen DP (HLA-DP) locus has been reported to be associated with hepatitis B virus (HBV) infection in populations of Japan and Thailand. We aimed to examine whether the association can be replicated in Han Chinese populations.<h4>Methodology/principal findings</h4>Two HLA-DP variants rs2395309 and rs9277535 (the most strongly associated SNPs from each HLA-DP locus) were genotyped in three independent Han cohorts consisting of 2 805 cases and 1 796 controls. By using logistic regression analysis, these two SNPs in the HLA-DPA1 and HLA-DPB1 genes were significantly associated with HBV infection in Han Chinese populations (P = 0.021∼3.36×10(-8) at rs2395309; P = 8.37×10(-3)∼2.68×10(-10) at rs9277535). In addition, the genotype distributions of both sites (rs2395309 and rs9277535) were clearly different between southern and northern Chinese population (P = 8.95×10(-5) at rs2395309; P = 1.64×10(-9) at rs9277535). By using asymptomatic HBV carrier as control group, our study showed that there were no associations of two HLA-DP variants with HBV progression (P = 0.305∼0.822 and 0.163∼0.881 in southern Chinese population, respectively; P = 0.097∼0.697 and 0.198∼0.615 in northern Chinese population, respectively).<h4>Conclusions</h4>Our results confirmed that two SNPs (rs2395309 and rs9277535) in the HLA-DP loci were strongly associated with HBV infection in southern and northern Han Chinese populations, but not with HBV progression. |
| format |
article |
| author |
Jin Li Daguo Yang Yongwen He Mengyi Wang Zirong Wen Lifeng Liu Jinjian Yao Koichi Matsuda Yusuke Nakamura Jinling Yu Xiaorui Jiang Shuzhen Sun Qing Liu Xiang Jiang Qilong Song Man Chen Hong Yang Feng Tang Xiaowen Hu Jing Wang Ying Chang Xingxing He Yuan Chen Jusheng Lin |
| author_facet |
Jin Li Daguo Yang Yongwen He Mengyi Wang Zirong Wen Lifeng Liu Jinjian Yao Koichi Matsuda Yusuke Nakamura Jinling Yu Xiaorui Jiang Shuzhen Sun Qing Liu Xiang Jiang Qilong Song Man Chen Hong Yang Feng Tang Xiaowen Hu Jing Wang Ying Chang Xingxing He Yuan Chen Jusheng Lin |
| author_sort |
Jin Li |
| title |
Associations of HLA-DP variants with hepatitis B virus infection in southern and northern Han Chinese populations: a multicenter case-control study. |
| title_short |
Associations of HLA-DP variants with hepatitis B virus infection in southern and northern Han Chinese populations: a multicenter case-control study. |
| title_full |
Associations of HLA-DP variants with hepatitis B virus infection in southern and northern Han Chinese populations: a multicenter case-control study. |
| title_fullStr |
Associations of HLA-DP variants with hepatitis B virus infection in southern and northern Han Chinese populations: a multicenter case-control study. |
| title_full_unstemmed |
Associations of HLA-DP variants with hepatitis B virus infection in southern and northern Han Chinese populations: a multicenter case-control study. |
| title_sort |
associations of hla-dp variants with hepatitis b virus infection in southern and northern han chinese populations: a multicenter case-control study. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/49808f46555a4951a0d02ac63e7e744d |
| work_keys_str_mv |
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