Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice

Obesity is a global pandemic with limited treatment options. Here, the authors show evidence in mice that the mitochondrial uncoupler BAM15 effectively induces fat loss without affecting food intake or compromising lean body mass.

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Autores principales:	Stephanie J. Alexopoulos, Sing-Young Chen, Amanda E. Brandon, Joseph M. Salamoun, Frances L. Byrne, Christopher J. Garcia, Martina Beretta, Ellen M. Olzomer, Divya P. Shah, Ashleigh M. Philp, Stefan R. Hargett, Robert T. Lawrence, Brendan Lee, James Sligar, Pascal Carrive, Simon P. Tucker, Andrew Philp, Carolin Lackner, Nigel Turner, Gregory J. Cooney, Webster L. Santos, Kyle L. Hoehn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/49822901a6bc47aea8285786f6119e85
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spelling	oai:doaj.org-article:49822901a6bc47aea8285786f6119e852021-12-02T15:43:06ZMitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice10.1038/s41467-020-16298-22041-1723https://doaj.org/article/49822901a6bc47aea8285786f6119e852020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16298-2https://doaj.org/toc/2041-1723Obesity is a global pandemic with limited treatment options. Here, the authors show evidence in mice that the mitochondrial uncoupler BAM15 effectively induces fat loss without affecting food intake or compromising lean body mass.Stephanie J. AlexopoulosSing-Young ChenAmanda E. BrandonJoseph M. SalamounFrances L. ByrneChristopher J. GarciaMartina BerettaEllen M. OlzomerDivya P. ShahAshleigh M. PhilpStefan R. HargettRobert T. LawrenceBrendan LeeJames SligarPascal CarriveSimon P. TuckerAndrew PhilpCarolin LacknerNigel TurnerGregory J. CooneyWebster L. SantosKyle L. HoehnNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephanie J. Alexopoulos Sing-Young Chen Amanda E. Brandon Joseph M. Salamoun Frances L. Byrne Christopher J. Garcia Martina Beretta Ellen M. Olzomer Divya P. Shah Ashleigh M. Philp Stefan R. Hargett Robert T. Lawrence Brendan Lee James Sligar Pascal Carrive Simon P. Tucker Andrew Philp Carolin Lackner Nigel Turner Gregory J. Cooney Webster L. Santos Kyle L. Hoehn Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice
description	Obesity is a global pandemic with limited treatment options. Here, the authors show evidence in mice that the mitochondrial uncoupler BAM15 effectively induces fat loss without affecting food intake or compromising lean body mass.
format	article
author	Stephanie J. Alexopoulos Sing-Young Chen Amanda E. Brandon Joseph M. Salamoun Frances L. Byrne Christopher J. Garcia Martina Beretta Ellen M. Olzomer Divya P. Shah Ashleigh M. Philp Stefan R. Hargett Robert T. Lawrence Brendan Lee James Sligar Pascal Carrive Simon P. Tucker Andrew Philp Carolin Lackner Nigel Turner Gregory J. Cooney Webster L. Santos Kyle L. Hoehn
author_facet	Stephanie J. Alexopoulos Sing-Young Chen Amanda E. Brandon Joseph M. Salamoun Frances L. Byrne Christopher J. Garcia Martina Beretta Ellen M. Olzomer Divya P. Shah Ashleigh M. Philp Stefan R. Hargett Robert T. Lawrence Brendan Lee James Sligar Pascal Carrive Simon P. Tucker Andrew Philp Carolin Lackner Nigel Turner Gregory J. Cooney Webster L. Santos Kyle L. Hoehn
author_sort	Stephanie J. Alexopoulos
title	Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice
title_short	Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice
title_full	Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice
title_fullStr	Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice
title_full_unstemmed	Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice
title_sort	mitochondrial uncoupler bam15 reverses diet-induced obesity and insulin resistance in mice
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/49822901a6bc47aea8285786f6119e85
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Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice

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