Conjunctive spatial and self-motion codes are topographically organized in the GABAergic cells of the lateral septum.

The hippocampal spatial code's relevance for downstream neuronal populations-particularly its major subcortical output the lateral septum (LS)-is still poorly understood. Here, using calcium imaging combined with unbiased analytical methods, we functionally characterized and compared the spatia...

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Autores principales:	Suzanne van der Veldt, Guillaume Etter, Coralie-Anne Mosser, Frédéric Manseau, Sylvain Williams
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/49844cae959b45b498393767fe59ff7e
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spelling	oai:doaj.org-article:49844cae959b45b498393767fe59ff7e2021-12-02T19:54:37ZConjunctive spatial and self-motion codes are topographically organized in the GABAergic cells of the lateral septum.1544-91731545-788510.1371/journal.pbio.3001383https://doaj.org/article/49844cae959b45b498393767fe59ff7e2021-08-01T00:00:00Zhttps://doi.org/10.1371/journal.pbio.3001383https://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885The hippocampal spatial code's relevance for downstream neuronal populations-particularly its major subcortical output the lateral septum (LS)-is still poorly understood. Here, using calcium imaging combined with unbiased analytical methods, we functionally characterized and compared the spatial tuning of LS GABAergic cells to those of dorsal CA3 and CA1 cells. We identified a significant number of LS cells that are modulated by place, speed, acceleration, and direction, as well as conjunctions of these properties, directly comparable to hippocampal CA1 and CA3 spatially modulated cells. Interestingly, Bayesian decoding of position based on LS spatial cells reflected the animal's location as accurately as decoding using the activity of hippocampal pyramidal cells. A portion of LS cells showed stable spatial codes over the course of multiple days, potentially reflecting long-term episodic memory. The distributions of cells exhibiting these properties formed gradients along the anterior-posterior and dorsal-ventral axes of the LS, directly reflecting the topographical organization of hippocampal inputs to the LS. Finally, we show using transsynaptic tracing that LS neurons receiving CA3 and CA1 excitatory input send projections to the hypothalamus and medial septum, regions that are not targeted directly by principal cells of the dorsal hippocampus. Together, our findings demonstrate that the LS accurately and robustly represents spatial, directional as well as self-motion information and is uniquely positioned to relay this information from the hippocampus to its downstream regions, thus occupying a key position within a distributed spatial memory network.Suzanne van der VeldtGuillaume EtterCoralie-Anne MosserFrédéric ManseauSylvain WilliamsPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 19, Iss 8, p e3001383 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Suzanne van der Veldt Guillaume Etter Coralie-Anne Mosser Frédéric Manseau Sylvain Williams Conjunctive spatial and self-motion codes are topographically organized in the GABAergic cells of the lateral septum.
description	The hippocampal spatial code's relevance for downstream neuronal populations-particularly its major subcortical output the lateral septum (LS)-is still poorly understood. Here, using calcium imaging combined with unbiased analytical methods, we functionally characterized and compared the spatial tuning of LS GABAergic cells to those of dorsal CA3 and CA1 cells. We identified a significant number of LS cells that are modulated by place, speed, acceleration, and direction, as well as conjunctions of these properties, directly comparable to hippocampal CA1 and CA3 spatially modulated cells. Interestingly, Bayesian decoding of position based on LS spatial cells reflected the animal's location as accurately as decoding using the activity of hippocampal pyramidal cells. A portion of LS cells showed stable spatial codes over the course of multiple days, potentially reflecting long-term episodic memory. The distributions of cells exhibiting these properties formed gradients along the anterior-posterior and dorsal-ventral axes of the LS, directly reflecting the topographical organization of hippocampal inputs to the LS. Finally, we show using transsynaptic tracing that LS neurons receiving CA3 and CA1 excitatory input send projections to the hypothalamus and medial septum, regions that are not targeted directly by principal cells of the dorsal hippocampus. Together, our findings demonstrate that the LS accurately and robustly represents spatial, directional as well as self-motion information and is uniquely positioned to relay this information from the hippocampus to its downstream regions, thus occupying a key position within a distributed spatial memory network.
format	article
author	Suzanne van der Veldt Guillaume Etter Coralie-Anne Mosser Frédéric Manseau Sylvain Williams
author_facet	Suzanne van der Veldt Guillaume Etter Coralie-Anne Mosser Frédéric Manseau Sylvain Williams
author_sort	Suzanne van der Veldt
title	Conjunctive spatial and self-motion codes are topographically organized in the GABAergic cells of the lateral septum.
title_short	Conjunctive spatial and self-motion codes are topographically organized in the GABAergic cells of the lateral septum.
title_full	Conjunctive spatial and self-motion codes are topographically organized in the GABAergic cells of the lateral septum.
title_fullStr	Conjunctive spatial and self-motion codes are topographically organized in the GABAergic cells of the lateral septum.
title_full_unstemmed	Conjunctive spatial and self-motion codes are topographically organized in the GABAergic cells of the lateral septum.
title_sort	conjunctive spatial and self-motion codes are topographically organized in the gabaergic cells of the lateral septum.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/49844cae959b45b498393767fe59ff7e
work_keys_str_mv	AT suzannevanderveldt conjunctivespatialandselfmotioncodesaretopographicallyorganizedinthegabaergiccellsofthelateralseptum AT guillaumeetter conjunctivespatialandselfmotioncodesaretopographicallyorganizedinthegabaergiccellsofthelateralseptum AT coralieannemosser conjunctivespatialandselfmotioncodesaretopographicallyorganizedinthegabaergiccellsofthelateralseptum AT fredericmanseau conjunctivespatialandselfmotioncodesaretopographicallyorganizedinthegabaergiccellsofthelateralseptum AT sylvainwilliams conjunctivespatialandselfmotioncodesaretopographicallyorganizedinthegabaergiccellsofthelateralseptum
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Conjunctive spatial and self-motion codes are topographically organized in the GABAergic cells of the lateral septum.

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