Effects of hydrothermal treatment on the properties of nanoapatite crystals

Wei Liang,1,* Yunfei Niu,2,* Shuhua Ge,1 Shaojun Song,2 Jiacan Su,2 Zhuojing Luo11Department of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi&rsquo;an, Shaanxi, People&rsquo;s Republic of China; 2Department of Orthopedics, Changhai Hospital, Second Military Med...

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Autores principales:	Liang W, Niu Y, Ge S, Song S, Su J, Luo Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4985a1933d1a46a585f6a7dfd1b4142a
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spelling	oai:doaj.org-article:4985a1933d1a46a585f6a7dfd1b4142a2021-12-02T04:21:22ZEffects of hydrothermal treatment on the properties of nanoapatite crystals1176-91141178-2013https://doaj.org/article/4985a1933d1a46a585f6a7dfd1b4142a2012-09-01T00:00:00Zhttp://www.dovepress.com/effects-of-hydrothermal-treatment-on-the-properties-of-nanoapatite-cry-a11140https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Wei Liang,1,* Yunfei Niu,2,* Shuhua Ge,1 Shaojun Song,2 Jiacan Su,2 Zhuojing Luo11Department of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi&rsquo;an, Shaanxi, People&rsquo;s Republic of China; 2Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, People&rsquo;s Republic of China*These authors contributed equally to this workAbstract: We report the synthesis of nanoapatite crystals via a hydrothermal reaction of hydroxyapatite precipitates. The impact of the reaction conditions on the properties of the crystals obtained were evaluated. The hydrothermal reaction that takes place markedly affected the crystallinity, morphology, and size of the nanoapatite crystals formed. High crystallinity and large crystal size were obtained at higher hydrothermal temperatures and longer hydrothermal reaction times. The nanoapatite crystals were needle-like when prepared under ambient pressure conditions and rod-like when prepared under increased pressure. The crystals prepared at ambient pressure had a larger aspect ratio compared with those prepared under increased pressure. The aging time of the initial hydroxyapatite precipitate significantly affected growth of the nanoapatite crystals. With other hydrothermal reaction conditions being equal, the fresh hydroxyapatite precipitate produced notably larger crystals than the aged hydroxyapatite precipitate. The influence of apatite morphology on osteoblast viability was studied by MTT assay. The results indicate that the rod-like apatite showed a better biological response than needle-like apatite in promoting cell growth. Transmission electron microscopy showed that large quantities of needle apatite entered into cells and damaged their morphology.Keywords: nanoapatite crystals, hydrothermal treatment, morphology, cell viabilityLiang WNiu YGe SSong SSu JLuo ZDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 5151-5158 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Liang W Niu Y Ge S Song S Su J Luo Z Effects of hydrothermal treatment on the properties of nanoapatite crystals
description	Wei Liang,1,* Yunfei Niu,2,* Shuhua Ge,1 Shaojun Song,2 Jiacan Su,2 Zhuojing Luo11Department of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi&rsquo;an, Shaanxi, People&rsquo;s Republic of China; 2Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, People&rsquo;s Republic of China*These authors contributed equally to this workAbstract: We report the synthesis of nanoapatite crystals via a hydrothermal reaction of hydroxyapatite precipitates. The impact of the reaction conditions on the properties of the crystals obtained were evaluated. The hydrothermal reaction that takes place markedly affected the crystallinity, morphology, and size of the nanoapatite crystals formed. High crystallinity and large crystal size were obtained at higher hydrothermal temperatures and longer hydrothermal reaction times. The nanoapatite crystals were needle-like when prepared under ambient pressure conditions and rod-like when prepared under increased pressure. The crystals prepared at ambient pressure had a larger aspect ratio compared with those prepared under increased pressure. The aging time of the initial hydroxyapatite precipitate significantly affected growth of the nanoapatite crystals. With other hydrothermal reaction conditions being equal, the fresh hydroxyapatite precipitate produced notably larger crystals than the aged hydroxyapatite precipitate. The influence of apatite morphology on osteoblast viability was studied by MTT assay. The results indicate that the rod-like apatite showed a better biological response than needle-like apatite in promoting cell growth. Transmission electron microscopy showed that large quantities of needle apatite entered into cells and damaged their morphology.Keywords: nanoapatite crystals, hydrothermal treatment, morphology, cell viability
format	article
author	Liang W Niu Y Ge S Song S Su J Luo Z
author_facet	Liang W Niu Y Ge S Song S Su J Luo Z
author_sort	Liang W
title	Effects of hydrothermal treatment on the properties of nanoapatite crystals
title_short	Effects of hydrothermal treatment on the properties of nanoapatite crystals
title_full	Effects of hydrothermal treatment on the properties of nanoapatite crystals
title_fullStr	Effects of hydrothermal treatment on the properties of nanoapatite crystals
title_full_unstemmed	Effects of hydrothermal treatment on the properties of nanoapatite crystals
title_sort	effects of hydrothermal treatment on the properties of nanoapatite crystals
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/4985a1933d1a46a585f6a7dfd1b4142a
work_keys_str_mv	AT liangw effectsofhydrothermaltreatmentonthepropertiesofnanoapatitecrystals AT niuy effectsofhydrothermaltreatmentonthepropertiesofnanoapatitecrystals AT ges effectsofhydrothermaltreatmentonthepropertiesofnanoapatitecrystals AT songs effectsofhydrothermaltreatmentonthepropertiesofnanoapatitecrystals AT suj effectsofhydrothermaltreatmentonthepropertiesofnanoapatitecrystals AT luoz effectsofhydrothermaltreatmentonthepropertiesofnanoapatitecrystals
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Effects of hydrothermal treatment on the properties of nanoapatite crystals

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