Anterior-segment morphology and corneal biomechanical characteristics in pigmentary glaucoma

Annemarie Klingenstein, Marcus Kernt, Florian Seidensticker, Anselm Kampik, Christoph HirneissDepartment of Ophthalmology, University of Munich Hospital, Ludwig-Maximilians University, Munich, GermanyPurpose: The aim of the study reported here was to evaluate characteristics of the anterior-segment...

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Autores principales:	Klingenstein A, Kernt M, Seidensticker F, Kampik A, Hirneiss C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/49867e14a129444599c649fe5c2901ca
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spelling	oai:doaj.org-article:49867e14a129444599c649fe5c2901ca2021-12-02T01:43:47ZAnterior-segment morphology and corneal biomechanical characteristics in pigmentary glaucoma1177-5483https://doaj.org/article/49867e14a129444599c649fe5c2901ca2013-12-01T00:00:00Zhttp://www.dovepress.com/anterior-segment-morphology-and-corneal-biomechanical-characteristics--a15407https://doaj.org/toc/1177-5483 Annemarie Klingenstein, Marcus Kernt, Florian Seidensticker, Anselm Kampik, Christoph HirneissDepartment of Ophthalmology, University of Munich Hospital, Ludwig-Maximilians University, Munich, GermanyPurpose: The aim of the study reported here was to evaluate characteristics of the anterior-segment via anterior-segment optical coherence tomography (AS-OCT) and corneal biomechanical properties using an ocular response analyzer and their changes by peripheral laser iridotomy (PI) in patients with pigmentary glaucoma (PG).Materials and methods: Seventeen eyes with PG were included consecutively. AS-OCT and ocular response analyzer measurements were taken before and 3 months after PI. Baseline morphology and change in morphology were analyzed by correlation and multiple linear regression analysis. The main parameters assessed were anterior-chamber (AC) angles and volume as well as corneal hysteresis (CH) and corneal resistance factor.Results: AC angles were found to have decreased significantly in each quadrant after PI (P<0.001), with the highest effect seen in the temporal quadrant, which decreased from 57.0°±9.6° to 44.1°±5.2° (± standard deviation). Mean AC volume decreased significantly from 213.1±36.4 to 187.0±23.4 mm3 (P<0.001). CH and corneal resistance factor did not change after PI. CH was found to correlate with the preoperative superior and inferior angle width (Spearman's rho 0.553 and 0.615, respectively, P<0.05). Biomechanical parameters showed no predictive value on the change of AC angles or volume.Conclusion: PI in eyes with PG results in a highly significant reduction in the AC angles and volume as visualized by AS-OCT, with the largest effect seen in the temporal quadrant. CH is strongly positively correlated with the superior and inferior preoperative AC angles, emphasizing the importance of the biomechanical properties of the cornea for glaucoma pathogenesis in PG, but corneal biomechanical properties cannot predict PI-related AC changes.Keywords: anterior-segment optical coherence tomography, ocular response analyzer, corneal hysteresisKlingenstein AKernt MSeidensticker FKampik AHirneiss CDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 119-126 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Klingenstein A Kernt M Seidensticker F Kampik A Hirneiss C Anterior-segment morphology and corneal biomechanical characteristics in pigmentary glaucoma
description	Annemarie Klingenstein, Marcus Kernt, Florian Seidensticker, Anselm Kampik, Christoph HirneissDepartment of Ophthalmology, University of Munich Hospital, Ludwig-Maximilians University, Munich, GermanyPurpose: The aim of the study reported here was to evaluate characteristics of the anterior-segment via anterior-segment optical coherence tomography (AS-OCT) and corneal biomechanical properties using an ocular response analyzer and their changes by peripheral laser iridotomy (PI) in patients with pigmentary glaucoma (PG).Materials and methods: Seventeen eyes with PG were included consecutively. AS-OCT and ocular response analyzer measurements were taken before and 3 months after PI. Baseline morphology and change in morphology were analyzed by correlation and multiple linear regression analysis. The main parameters assessed were anterior-chamber (AC) angles and volume as well as corneal hysteresis (CH) and corneal resistance factor.Results: AC angles were found to have decreased significantly in each quadrant after PI (P<0.001), with the highest effect seen in the temporal quadrant, which decreased from 57.0°±9.6° to 44.1°±5.2° (± standard deviation). Mean AC volume decreased significantly from 213.1±36.4 to 187.0±23.4 mm3 (P<0.001). CH and corneal resistance factor did not change after PI. CH was found to correlate with the preoperative superior and inferior angle width (Spearman's rho 0.553 and 0.615, respectively, P<0.05). Biomechanical parameters showed no predictive value on the change of AC angles or volume.Conclusion: PI in eyes with PG results in a highly significant reduction in the AC angles and volume as visualized by AS-OCT, with the largest effect seen in the temporal quadrant. CH is strongly positively correlated with the superior and inferior preoperative AC angles, emphasizing the importance of the biomechanical properties of the cornea for glaucoma pathogenesis in PG, but corneal biomechanical properties cannot predict PI-related AC changes.Keywords: anterior-segment optical coherence tomography, ocular response analyzer, corneal hysteresis
format	article
author	Klingenstein A Kernt M Seidensticker F Kampik A Hirneiss C
author_facet	Klingenstein A Kernt M Seidensticker F Kampik A Hirneiss C
author_sort	Klingenstein A
title	Anterior-segment morphology and corneal biomechanical characteristics in pigmentary glaucoma
title_short	Anterior-segment morphology and corneal biomechanical characteristics in pigmentary glaucoma
title_full	Anterior-segment morphology and corneal biomechanical characteristics in pigmentary glaucoma
title_fullStr	Anterior-segment morphology and corneal biomechanical characteristics in pigmentary glaucoma
title_full_unstemmed	Anterior-segment morphology and corneal biomechanical characteristics in pigmentary glaucoma
title_sort	anterior-segment morphology and corneal biomechanical characteristics in pigmentary glaucoma
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/49867e14a129444599c649fe5c2901ca
work_keys_str_mv	AT klingensteina anteriorsegmentmorphologyandcornealbiomechanicalcharacteristicsinpigmentaryglaucoma AT kerntm anteriorsegmentmorphologyandcornealbiomechanicalcharacteristicsinpigmentaryglaucoma AT seidenstickerf anteriorsegmentmorphologyandcornealbiomechanicalcharacteristicsinpigmentaryglaucoma AT kampika anteriorsegmentmorphologyandcornealbiomechanicalcharacteristicsinpigmentaryglaucoma AT hirneissc anteriorsegmentmorphologyandcornealbiomechanicalcharacteristicsinpigmentaryglaucoma
_version_	1718402893312163840

Anterior-segment morphology and corneal biomechanical characteristics in pigmentary glaucoma

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