Association between leptin and delirium in elderly inpatients

Julio C Sánchez, Jenny P Ospina, Martha I GonzálezCell and Applied Physiology Group, Department of Basic Sciences, Faculty of Health, Universidad Tecnológica de Pereira, Pereira, ColombiaAbstract: Leptin is a hormone with significant effects on the brain, both at the...

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Autores principales:	Sanchez JC, Ospina JP, Gonzalez MI
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/49931e9a4c2a42899f4cdaacfde78e25
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spelling	oai:doaj.org-article:49931e9a4c2a42899f4cdaacfde78e252021-12-02T06:59:35ZAssociation between leptin and delirium in elderly inpatients1176-63281178-2021https://doaj.org/article/49931e9a4c2a42899f4cdaacfde78e252013-05-01T00:00:00Zhttp://www.dovepress.com/association-between-leptin-and-delirium-in-elderly-inpatients-a13029https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Julio C Sánchez, Jenny P Ospina, Martha I GonzálezCell and Applied Physiology Group, Department of Basic Sciences, Faculty of Health, Universidad Tecnológica de Pereira, Pereira, ColombiaAbstract: Leptin is a hormone with significant effects on the brain, both at the cellular level and cognitive level. This study aimed to establish the association between leptin levels and delirium in a Colombian elderly population. 115 patients older than 60 years were included. Leptin was measured by enzyme-linked immunosorbent assay after overnight fasting and Mini-Mental State Examination and Confusion Assessment Method (CAM) tests were employed. Delirium was diagnosed using CAM in 23.48% of patients, being most frequent in men. There were no significant differences in hematology and renal test values between patients with delirium and those without delirium, but cerebrovascular diagnoses were more frequent in patients with delirium. No correlation with any specific medication was found, but patients with delirium had a higher number of comorbidities and medications. Leptin levels were significantly lower in patients with delirium and correlated negatively with the number of diagnoses and medications, but not with age, gender, body mass index, or hematology and renal test results. Leptin levels may have a role in the pathophysiological process of delirium and low leptin could be a useful clinical biomarker to establish risk in elderly patients given the association with delirium.Keywords: delirium, elderly, hospitalization, leptinSanchez JCOspina JPGonzalez MIDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2013, Iss default, Pp 659-666 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Sanchez JC Ospina JP Gonzalez MI Association between leptin and delirium in elderly inpatients
description	Julio C Sánchez, Jenny P Ospina, Martha I GonzálezCell and Applied Physiology Group, Department of Basic Sciences, Faculty of Health, Universidad Tecnológica de Pereira, Pereira, ColombiaAbstract: Leptin is a hormone with significant effects on the brain, both at the cellular level and cognitive level. This study aimed to establish the association between leptin levels and delirium in a Colombian elderly population. 115 patients older than 60 years were included. Leptin was measured by enzyme-linked immunosorbent assay after overnight fasting and Mini-Mental State Examination and Confusion Assessment Method (CAM) tests were employed. Delirium was diagnosed using CAM in 23.48% of patients, being most frequent in men. There were no significant differences in hematology and renal test values between patients with delirium and those without delirium, but cerebrovascular diagnoses were more frequent in patients with delirium. No correlation with any specific medication was found, but patients with delirium had a higher number of comorbidities and medications. Leptin levels were significantly lower in patients with delirium and correlated negatively with the number of diagnoses and medications, but not with age, gender, body mass index, or hematology and renal test results. Leptin levels may have a role in the pathophysiological process of delirium and low leptin could be a useful clinical biomarker to establish risk in elderly patients given the association with delirium.Keywords: delirium, elderly, hospitalization, leptin
format	article
author	Sanchez JC Ospina JP Gonzalez MI
author_facet	Sanchez JC Ospina JP Gonzalez MI
author_sort	Sanchez JC
title	Association between leptin and delirium in elderly inpatients
title_short	Association between leptin and delirium in elderly inpatients
title_full	Association between leptin and delirium in elderly inpatients
title_fullStr	Association between leptin and delirium in elderly inpatients
title_full_unstemmed	Association between leptin and delirium in elderly inpatients
title_sort	association between leptin and delirium in elderly inpatients
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/49931e9a4c2a42899f4cdaacfde78e25
work_keys_str_mv	AT sanchezjc associationbetweenleptinanddeliriuminelderlyinpatients AT ospinajp associationbetweenleptinanddeliriuminelderlyinpatients AT gonzalezmi associationbetweenleptinanddeliriuminelderlyinpatients
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Association between leptin and delirium in elderly inpatients

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