Developmental diet regulates Drosophila lifespan via lipid autotoxins

The diet consumed during development can have long-lasting effects on adult physiology. Here, the authors show that developmental undernutrition in Drosophila extends lifespan by inhibiting the production of toxic lipids, called autotoxins, on the adult body surface.

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Autores principales:	M. Irina Stefana, Paul C. Driscoll, Fumiaki Obata, Ana Raquel Pengelly, Clare L. Newell, James I. MacRae, Alex P. Gould
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/49964fcd24ae4bed8845eb15473aa509
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spelling	oai:doaj.org-article:49964fcd24ae4bed8845eb15473aa5092021-12-02T15:38:48ZDevelopmental diet regulates Drosophila lifespan via lipid autotoxins10.1038/s41467-017-01740-92041-1723https://doaj.org/article/49964fcd24ae4bed8845eb15473aa5092017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01740-9https://doaj.org/toc/2041-1723The diet consumed during development can have long-lasting effects on adult physiology. Here, the authors show that developmental undernutrition in Drosophila extends lifespan by inhibiting the production of toxic lipids, called autotoxins, on the adult body surface.M. Irina StefanaPaul C. DriscollFumiaki ObataAna Raquel PengellyClare L. NewellJames I. MacRaeAlex P. GouldNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q M. Irina Stefana Paul C. Driscoll Fumiaki Obata Ana Raquel Pengelly Clare L. Newell James I. MacRae Alex P. Gould Developmental diet regulates Drosophila lifespan via lipid autotoxins
description	The diet consumed during development can have long-lasting effects on adult physiology. Here, the authors show that developmental undernutrition in Drosophila extends lifespan by inhibiting the production of toxic lipids, called autotoxins, on the adult body surface.
format	article
author	M. Irina Stefana Paul C. Driscoll Fumiaki Obata Ana Raquel Pengelly Clare L. Newell James I. MacRae Alex P. Gould
author_facet	M. Irina Stefana Paul C. Driscoll Fumiaki Obata Ana Raquel Pengelly Clare L. Newell James I. MacRae Alex P. Gould
author_sort	M. Irina Stefana
title	Developmental diet regulates Drosophila lifespan via lipid autotoxins
title_short	Developmental diet regulates Drosophila lifespan via lipid autotoxins
title_full	Developmental diet regulates Drosophila lifespan via lipid autotoxins
title_fullStr	Developmental diet regulates Drosophila lifespan via lipid autotoxins
title_full_unstemmed	Developmental diet regulates Drosophila lifespan via lipid autotoxins
title_sort	developmental diet regulates drosophila lifespan via lipid autotoxins
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/49964fcd24ae4bed8845eb15473aa509
work_keys_str_mv	AT mirinastefana developmentaldietregulatesdrosophilalifespanvialipidautotoxins AT paulcdriscoll developmentaldietregulatesdrosophilalifespanvialipidautotoxins AT fumiakiobata developmentaldietregulatesdrosophilalifespanvialipidautotoxins AT anaraquelpengelly developmentaldietregulatesdrosophilalifespanvialipidautotoxins AT clarelnewell developmentaldietregulatesdrosophilalifespanvialipidautotoxins AT jamesimacrae developmentaldietregulatesdrosophilalifespanvialipidautotoxins AT alexpgould developmentaldietregulatesdrosophilalifespanvialipidautotoxins
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Developmental diet regulates Drosophila lifespan via lipid autotoxins

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