Motor learning deficits in cervical dystonia point to defective basal ganglia circuitry

Abstract Dystonia is conceptualized as a network disorder involving basal ganglia, thalamus, sensorimotor cortex and the cerebellum. The cerebellum has been implicated in dystonia pathophysiology, but studies testing cerebellar function in dystonia patients have provided equivocal results. This stud...

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Autores principales:	Sebastian Loens, Julius Verrel, Vera-Maria Herrmann, Amrei Kienzle, Elinor Tzvi, Anne Weissbach, Johanna Junker, Alexander Münchau, Tobias Bäumer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/49976536abc145b299f1f39e447a50fc
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spelling	oai:doaj.org-article:49976536abc145b299f1f39e447a50fc2021-12-02T18:18:06ZMotor learning deficits in cervical dystonia point to defective basal ganglia circuitry10.1038/s41598-021-86513-72045-2322https://doaj.org/article/49976536abc145b299f1f39e447a50fc2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86513-7https://doaj.org/toc/2045-2322Abstract Dystonia is conceptualized as a network disorder involving basal ganglia, thalamus, sensorimotor cortex and the cerebellum. The cerebellum has been implicated in dystonia pathophysiology, but studies testing cerebellar function in dystonia patients have provided equivocal results. This study aimed to further elucidate motor network deficits in cervical dystonia with special interest in the role of the cerebellum. To this end we investigated motor learning tasks, that differ in their dependence on cerebellar and basal ganglia functioning. In 18 cervical dystonia patients and 18 age matched healthy controls we measured implicit motor sequence learning using a 12-item serial reaction time task mostly targeting basal ganglia circuitry and motor adaptation and eyeblink conditioning as markers of cerebellar functioning. ANOVA showed that motor sequence learning was overall impaired in cervical dystonia (p = 0.01). Moreover, unlike healthy controls, patients did not show a learning effect in the first part of the experiment. Visuomotor adaptation and eyeblink conditioning were normal. In conclusion, these data lend support to the notion that motor learning deficits in cervical dystonia relate to basal ganglia-thalamo-cortical loops rather than being a result of defective cerebellar circuitry.Sebastian LoensJulius VerrelVera-Maria HerrmannAmrei KienzleElinor TzviAnne WeissbachJohanna JunkerAlexander MünchauTobias BäumerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sebastian Loens Julius Verrel Vera-Maria Herrmann Amrei Kienzle Elinor Tzvi Anne Weissbach Johanna Junker Alexander Münchau Tobias Bäumer Motor learning deficits in cervical dystonia point to defective basal ganglia circuitry
description	Abstract Dystonia is conceptualized as a network disorder involving basal ganglia, thalamus, sensorimotor cortex and the cerebellum. The cerebellum has been implicated in dystonia pathophysiology, but studies testing cerebellar function in dystonia patients have provided equivocal results. This study aimed to further elucidate motor network deficits in cervical dystonia with special interest in the role of the cerebellum. To this end we investigated motor learning tasks, that differ in their dependence on cerebellar and basal ganglia functioning. In 18 cervical dystonia patients and 18 age matched healthy controls we measured implicit motor sequence learning using a 12-item serial reaction time task mostly targeting basal ganglia circuitry and motor adaptation and eyeblink conditioning as markers of cerebellar functioning. ANOVA showed that motor sequence learning was overall impaired in cervical dystonia (p = 0.01). Moreover, unlike healthy controls, patients did not show a learning effect in the first part of the experiment. Visuomotor adaptation and eyeblink conditioning were normal. In conclusion, these data lend support to the notion that motor learning deficits in cervical dystonia relate to basal ganglia-thalamo-cortical loops rather than being a result of defective cerebellar circuitry.
format	article
author	Sebastian Loens Julius Verrel Vera-Maria Herrmann Amrei Kienzle Elinor Tzvi Anne Weissbach Johanna Junker Alexander Münchau Tobias Bäumer
author_facet	Sebastian Loens Julius Verrel Vera-Maria Herrmann Amrei Kienzle Elinor Tzvi Anne Weissbach Johanna Junker Alexander Münchau Tobias Bäumer
author_sort	Sebastian Loens
title	Motor learning deficits in cervical dystonia point to defective basal ganglia circuitry
title_short	Motor learning deficits in cervical dystonia point to defective basal ganglia circuitry
title_full	Motor learning deficits in cervical dystonia point to defective basal ganglia circuitry
title_fullStr	Motor learning deficits in cervical dystonia point to defective basal ganglia circuitry
title_full_unstemmed	Motor learning deficits in cervical dystonia point to defective basal ganglia circuitry
title_sort	motor learning deficits in cervical dystonia point to defective basal ganglia circuitry
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/49976536abc145b299f1f39e447a50fc
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Motor learning deficits in cervical dystonia point to defective basal ganglia circuitry

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