Periodical reactivation under the effect of caffeine attenuates fear memory expression in rats

Abstract In the last decade, several studies have shown that fear memories can be attenuated by interfering with reconsolidation. However, most of the pharmacological agents used in preclinical studies cannot be administered to humans. Caffeine is one of the world’s most popular psychoactive drugs a...

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Autores principales:	Lizeth K. Pedraza, Rodrigo O. Sierra, Fernanda N. Lotz, Lucas de Oliveira Alvares
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/499fdece630e4c46b1aeea981a781dcd
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spelling	oai:doaj.org-article:499fdece630e4c46b1aeea981a781dcd2021-12-02T11:41:24ZPeriodical reactivation under the effect of caffeine attenuates fear memory expression in rats10.1038/s41598-018-25648-62045-2322https://doaj.org/article/499fdece630e4c46b1aeea981a781dcd2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25648-6https://doaj.org/toc/2045-2322Abstract In the last decade, several studies have shown that fear memories can be attenuated by interfering with reconsolidation. However, most of the pharmacological agents used in preclinical studies cannot be administered to humans. Caffeine is one of the world’s most popular psychoactive drugs and its effects on cognitive and mood states are well documented. Nevertheless, the influence of caffeine administration on fear memory processing is not as clear. We employed contextual fear conditioning in rats and acute caffeine administration under a standard memory reconsolidation protocol or periodical memory reactivation. Additionally, potential rewarding/aversion and anxiety effects induced by caffeine were evaluated by conditioning place preference or open field, respectively. Caffeine administration was able to attenuate weak fear memories in a standard memory reconsolidation protocol; however, periodical memory reactivation under caffeine effect was necessary to attenuate strong and remote memories. Moreover, caffeine promoted conditioned place preference and anxiolytic-like behavior, suggesting that caffeine weakens the initial learning during reactivation through counterconditioning mechanisms. Thus, our study shows that rewarding and anxiolytic effects of caffeine during fear reactivation can change the emotional valence of fear memory. It brings a new promising pharmacological approach based on drugs widely used such as caffeine to treat fear-related disorders.Lizeth K. PedrazaRodrigo O. SierraFernanda N. LotzLucas de Oliveira AlvaresNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lizeth K. Pedraza Rodrigo O. Sierra Fernanda N. Lotz Lucas de Oliveira Alvares Periodical reactivation under the effect of caffeine attenuates fear memory expression in rats
description	Abstract In the last decade, several studies have shown that fear memories can be attenuated by interfering with reconsolidation. However, most of the pharmacological agents used in preclinical studies cannot be administered to humans. Caffeine is one of the world’s most popular psychoactive drugs and its effects on cognitive and mood states are well documented. Nevertheless, the influence of caffeine administration on fear memory processing is not as clear. We employed contextual fear conditioning in rats and acute caffeine administration under a standard memory reconsolidation protocol or periodical memory reactivation. Additionally, potential rewarding/aversion and anxiety effects induced by caffeine were evaluated by conditioning place preference or open field, respectively. Caffeine administration was able to attenuate weak fear memories in a standard memory reconsolidation protocol; however, periodical memory reactivation under caffeine effect was necessary to attenuate strong and remote memories. Moreover, caffeine promoted conditioned place preference and anxiolytic-like behavior, suggesting that caffeine weakens the initial learning during reactivation through counterconditioning mechanisms. Thus, our study shows that rewarding and anxiolytic effects of caffeine during fear reactivation can change the emotional valence of fear memory. It brings a new promising pharmacological approach based on drugs widely used such as caffeine to treat fear-related disorders.
format	article
author	Lizeth K. Pedraza Rodrigo O. Sierra Fernanda N. Lotz Lucas de Oliveira Alvares
author_facet	Lizeth K. Pedraza Rodrigo O. Sierra Fernanda N. Lotz Lucas de Oliveira Alvares
author_sort	Lizeth K. Pedraza
title	Periodical reactivation under the effect of caffeine attenuates fear memory expression in rats
title_short	Periodical reactivation under the effect of caffeine attenuates fear memory expression in rats
title_full	Periodical reactivation under the effect of caffeine attenuates fear memory expression in rats
title_fullStr	Periodical reactivation under the effect of caffeine attenuates fear memory expression in rats
title_full_unstemmed	Periodical reactivation under the effect of caffeine attenuates fear memory expression in rats
title_sort	periodical reactivation under the effect of caffeine attenuates fear memory expression in rats
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/499fdece630e4c46b1aeea981a781dcd
work_keys_str_mv	AT lizethkpedraza periodicalreactivationundertheeffectofcaffeineattenuatesfearmemoryexpressioninrats AT rodrigoosierra periodicalreactivationundertheeffectofcaffeineattenuatesfearmemoryexpressioninrats AT fernandanlotz periodicalreactivationundertheeffectofcaffeineattenuatesfearmemoryexpressioninrats AT lucasdeoliveiraalvares periodicalreactivationundertheeffectofcaffeineattenuatesfearmemoryexpressioninrats
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Periodical reactivation under the effect of caffeine attenuates fear memory expression in rats

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