Lkb1 suppresses amino acid-driven gluconeogenesis in the liver

Lkb1 suppresses amino acid-driven gluconeogenesis in the liver

Excessive glucose production by the liver contributes to poor blood glucose control in type 2 diabetes. Here the authors report that the liver kinase B1 (Lkb1) suppresses amino acid driven postprandial glucose production in the liver through the aminotransferase Agxt.

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Detalles Bibliográficos
Autores principales: Pierre-Alexandre Just, Sara Charawi, Raphaël G. P. Denis, Mathilde Savall, Massiré Traore, Marc Foretz, Sultan Bastu, Salimata Magassa, Nadia Senni, Pierre Sohier, Maud Wursmer, Mireille Vasseur-Cognet, Alain Schmitt, Morgane Le Gall, Marjorie Leduc, François Guillonneau, Jean-Pascal De Bandt, Patrick Mayeux, Béatrice Romagnolo, Serge Luquet, Pascale Bossard, Christine Perret
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
Q
Acceso en línea:https://doaj.org/article/49a408701c7e4900947294274a14936e
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Descripción
Sumario:Excessive glucose production by the liver contributes to poor blood glucose control in type 2 diabetes. Here the authors report that the liver kinase B1 (Lkb1) suppresses amino acid driven postprandial glucose production in the liver through the aminotransferase Agxt.

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