Lkb1 suppresses amino acid-driven gluconeogenesis in the liver

Excessive glucose production by the liver contributes to poor blood glucose control in type 2 diabetes. Here the authors report that the liver kinase B1 (Lkb1) suppresses amino acid driven postprandial glucose production in the liver through the aminotransferase Agxt.

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Autores principales:	Pierre-Alexandre Just, Sara Charawi, Raphaël G. P. Denis, Mathilde Savall, Massiré Traore, Marc Foretz, Sultan Bastu, Salimata Magassa, Nadia Senni, Pierre Sohier, Maud Wursmer, Mireille Vasseur-Cognet, Alain Schmitt, Morgane Le Gall, Marjorie Leduc, François Guillonneau, Jean-Pascal De Bandt, Patrick Mayeux, Béatrice Romagnolo, Serge Luquet, Pascale Bossard, Christine Perret
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/49a408701c7e4900947294274a14936e
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spelling	oai:doaj.org-article:49a408701c7e4900947294274a14936e2021-12-02T16:56:33ZLkb1 suppresses amino acid-driven gluconeogenesis in the liver10.1038/s41467-020-19490-62041-1723https://doaj.org/article/49a408701c7e4900947294274a14936e2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19490-6https://doaj.org/toc/2041-1723Excessive glucose production by the liver contributes to poor blood glucose control in type 2 diabetes. Here the authors report that the liver kinase B1 (Lkb1) suppresses amino acid driven postprandial glucose production in the liver through the aminotransferase Agxt.Pierre-Alexandre JustSara CharawiRaphaël G. P. DenisMathilde SavallMassiré TraoreMarc ForetzSultan BastuSalimata MagassaNadia SenniPierre SohierMaud WursmerMireille Vasseur-CognetAlain SchmittMorgane Le GallMarjorie LeducFrançois GuillonneauJean-Pascal De BandtPatrick MayeuxBéatrice RomagnoloSerge LuquetPascale BossardChristine PerretNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pierre-Alexandre Just Sara Charawi Raphaël G. P. Denis Mathilde Savall Massiré Traore Marc Foretz Sultan Bastu Salimata Magassa Nadia Senni Pierre Sohier Maud Wursmer Mireille Vasseur-Cognet Alain Schmitt Morgane Le Gall Marjorie Leduc François Guillonneau Jean-Pascal De Bandt Patrick Mayeux Béatrice Romagnolo Serge Luquet Pascale Bossard Christine Perret Lkb1 suppresses amino acid-driven gluconeogenesis in the liver
description	Excessive glucose production by the liver contributes to poor blood glucose control in type 2 diabetes. Here the authors report that the liver kinase B1 (Lkb1) suppresses amino acid driven postprandial glucose production in the liver through the aminotransferase Agxt.
format	article
author	Pierre-Alexandre Just Sara Charawi Raphaël G. P. Denis Mathilde Savall Massiré Traore Marc Foretz Sultan Bastu Salimata Magassa Nadia Senni Pierre Sohier Maud Wursmer Mireille Vasseur-Cognet Alain Schmitt Morgane Le Gall Marjorie Leduc François Guillonneau Jean-Pascal De Bandt Patrick Mayeux Béatrice Romagnolo Serge Luquet Pascale Bossard Christine Perret
author_facet	Pierre-Alexandre Just Sara Charawi Raphaël G. P. Denis Mathilde Savall Massiré Traore Marc Foretz Sultan Bastu Salimata Magassa Nadia Senni Pierre Sohier Maud Wursmer Mireille Vasseur-Cognet Alain Schmitt Morgane Le Gall Marjorie Leduc François Guillonneau Jean-Pascal De Bandt Patrick Mayeux Béatrice Romagnolo Serge Luquet Pascale Bossard Christine Perret
author_sort	Pierre-Alexandre Just
title	Lkb1 suppresses amino acid-driven gluconeogenesis in the liver
title_short	Lkb1 suppresses amino acid-driven gluconeogenesis in the liver
title_full	Lkb1 suppresses amino acid-driven gluconeogenesis in the liver
title_fullStr	Lkb1 suppresses amino acid-driven gluconeogenesis in the liver
title_full_unstemmed	Lkb1 suppresses amino acid-driven gluconeogenesis in the liver
title_sort	lkb1 suppresses amino acid-driven gluconeogenesis in the liver
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/49a408701c7e4900947294274a14936e
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Lkb1 suppresses amino acid-driven gluconeogenesis in the liver

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