BMP9 stimulates joint regeneration at digit amputation wounds in mice

Mammalian joints have poor regenerative capacity following amputation. Here, the authors show that in mice, stimulation of the amputation wound with BMP2 and BMP9 stimulates regeneration of a synovial joint that includes bone, cartilage and a synovial cavity.

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Autores principales:	Ling Yu, Lindsay A. Dawson, Mingquan Yan, Katherine Zimmel, Yu-Lieh Lin, Connor P. Dolan, Manjong Han, Ken Muneoka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/49ab87b3687b4f1eb6f372b52b35bc94
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spelling	oai:doaj.org-article:49ab87b3687b4f1eb6f372b52b35bc942021-12-02T15:35:38ZBMP9 stimulates joint regeneration at digit amputation wounds in mice10.1038/s41467-018-08278-42041-1723https://doaj.org/article/49ab87b3687b4f1eb6f372b52b35bc942019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08278-4https://doaj.org/toc/2041-1723Mammalian joints have poor regenerative capacity following amputation. Here, the authors show that in mice, stimulation of the amputation wound with BMP2 and BMP9 stimulates regeneration of a synovial joint that includes bone, cartilage and a synovial cavity.Ling YuLindsay A. DawsonMingquan YanKatherine ZimmelYu-Lieh LinConnor P. DolanManjong HanKen MuneokaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ling Yu Lindsay A. Dawson Mingquan Yan Katherine Zimmel Yu-Lieh Lin Connor P. Dolan Manjong Han Ken Muneoka BMP9 stimulates joint regeneration at digit amputation wounds in mice
description	Mammalian joints have poor regenerative capacity following amputation. Here, the authors show that in mice, stimulation of the amputation wound with BMP2 and BMP9 stimulates regeneration of a synovial joint that includes bone, cartilage and a synovial cavity.
format	article
author	Ling Yu Lindsay A. Dawson Mingquan Yan Katherine Zimmel Yu-Lieh Lin Connor P. Dolan Manjong Han Ken Muneoka
author_facet	Ling Yu Lindsay A. Dawson Mingquan Yan Katherine Zimmel Yu-Lieh Lin Connor P. Dolan Manjong Han Ken Muneoka
author_sort	Ling Yu
title	BMP9 stimulates joint regeneration at digit amputation wounds in mice
title_short	BMP9 stimulates joint regeneration at digit amputation wounds in mice
title_full	BMP9 stimulates joint regeneration at digit amputation wounds in mice
title_fullStr	BMP9 stimulates joint regeneration at digit amputation wounds in mice
title_full_unstemmed	BMP9 stimulates joint regeneration at digit amputation wounds in mice
title_sort	bmp9 stimulates joint regeneration at digit amputation wounds in mice
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/49ab87b3687b4f1eb6f372b52b35bc94
work_keys_str_mv	AT lingyu bmp9stimulatesjointregenerationatdigitamputationwoundsinmice AT lindsayadawson bmp9stimulatesjointregenerationatdigitamputationwoundsinmice AT mingquanyan bmp9stimulatesjointregenerationatdigitamputationwoundsinmice AT katherinezimmel bmp9stimulatesjointregenerationatdigitamputationwoundsinmice AT yuliehlin bmp9stimulatesjointregenerationatdigitamputationwoundsinmice AT connorpdolan bmp9stimulatesjointregenerationatdigitamputationwoundsinmice AT manjonghan bmp9stimulatesjointregenerationatdigitamputationwoundsinmice AT kenmuneoka bmp9stimulatesjointregenerationatdigitamputationwoundsinmice
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BMP9 stimulates joint regeneration at digit amputation wounds in mice

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