The frequency and spectrum of PIK3CA mutations in patients with estrogen receptor-positive HER2-negative advanced breast cancer residing in various regions of Russia

Relevance. PIK3CA belongs to the top three most frequently mutated genes in breast cancer (BC), especially in estrogen receptor (ER) positive, HER2 negative BC subtype. With an approval of selective PI3K-alpha inhibitor, alpelisib, this alteration has become actionable in ER+HER2- tumors. The freque...

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Autores principales: Tatiana N. Sokolova, Svetlana N. Aleksakhina, Grigoriy A. Yanus, Aleksandr V. Sultanbaev, Konstantin V. Menshikov, Anna N. Lysenko, Ruslan A. Zukov, Alena V. Zyuzyukina, Yulia N. Murunova, Elena I. Rossokha, Sergey Y. Bakharev, Elena A. Basova, Tatiana A. Kasmynina, Irina S. Shumskaya, Yana I. Bakshun, Khedi S. Musaeva, Alfia I. Khasanova, Vadim N. Dmitriev, Marina B. Bolieva, Christina H. Gadzaova, Oleg L. Petrenko, Dmitriy A. Maksimov, Vladimir I. Vladimirov, Viktor E. Goldberg, Nataliya O. Popova, Marianna V. Kibisheva, Zaur M. Khamgokov, Alexey E. Vasilyev, Aglaya G. Iyevleva, Evgeny N. Imyanitov
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Publicado: IP Habib O.N. 2021
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spelling oai:doaj.org-article:49ac17b627194a6ea7e6222ff26d5a942021-11-30T16:55:00ZThe frequency and spectrum of PIK3CA mutations in patients with estrogen receptor-positive HER2-negative advanced breast cancer residing in various regions of Russia1815-14341815-144210.26442/18151434.2021.1.200744https://doaj.org/article/49ac17b627194a6ea7e6222ff26d5a942021-05-01T00:00:00Zhttps://modernonco.orscience.ru/1815-1434/article/viewFile/70305/51240https://doaj.org/toc/1815-1434https://doaj.org/toc/1815-1442Relevance. PIK3CA belongs to the top three most frequently mutated genes in breast cancer (BC), especially in estrogen receptor (ER) positive, HER2 negative BC subtype. With an approval of selective PI3K-alpha inhibitor, alpelisib, this alteration has become actionable in ER+HER2- tumors. The frequency and spectrum of PIK3CA alterations in various cohorts is affected by a number of factors, including the distribution of BC expression subtypes, histological types, patient age, and even ethnicity. Aim. Aim of the current study was to characterize the frequency and spectrum of PIK3CA alterations in Russian BC patients. Materials and methods. The analysis of PIK3CA exon 7, 9 and 20 mutations was performed in a cohort of Russian ER+HER2- BC patients by a combination of high-resolution melting analysis, allele-specific PCR, and digital droplet PCR. Results. PIK3CA lesions were identified in 62/206 (30%) patients. Noteworthy, 59/62 (95%) of the identified variants were represented by the three most common p.E542K, p.E545K, and p.H1047R substitutions. The analysis of clinical and morphological characteristics revealed the trends towards association of PIK3CA mutations with older age and more frequent metastatic lung involvement. Conclusion. The obtained data on the frequency and spectrum of PIK3CA somatic aberrations can be helpful when organizing molecular genetic testing of breast cancer patients and using PI3K inhibitors in Russian population.Tatiana N. SokolovaSvetlana N. AleksakhinaGrigoriy A. YanusAleksandr V. SultanbaevKonstantin V. MenshikovAnna N. LysenkoRuslan A. ZukovAlena V. ZyuzyukinaYulia N. MurunovaElena I. RossokhaSergey Y. BakharevElena A. BasovaTatiana A. KasmyninaIrina S. ShumskayaYana I. BakshunKhedi S. MusaevaAlfia I. KhasanovaVadim N. DmitrievMarina B. BolievaChristina H. GadzaovaOleg L. PetrenkoDmitriy A. MaksimovVladimir I. VladimirovViktor E. GoldbergNataliya O. PopovaMarianna V. KibishevaZaur M. KhamgokovAlexey E. VasilyevAglaya G. IyevlevaEvgeny N. ImyanitovIP Habib O.N.articlebreast cancermutationspik3caalpelisibNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282RUСовременная онкология, Vol 23, Iss 1, Pp 61-67 (2021)
institution DOAJ
collection DOAJ
language RU
topic breast cancer
mutations
pik3ca
alpelisib
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
spellingShingle breast cancer
mutations
pik3ca
alpelisib
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Tatiana N. Sokolova
Svetlana N. Aleksakhina
Grigoriy A. Yanus
Aleksandr V. Sultanbaev
Konstantin V. Menshikov
Anna N. Lysenko
Ruslan A. Zukov
Alena V. Zyuzyukina
Yulia N. Murunova
Elena I. Rossokha
Sergey Y. Bakharev
Elena A. Basova
Tatiana A. Kasmynina
Irina S. Shumskaya
Yana I. Bakshun
Khedi S. Musaeva
Alfia I. Khasanova
Vadim N. Dmitriev
Marina B. Bolieva
Christina H. Gadzaova
Oleg L. Petrenko
Dmitriy A. Maksimov
Vladimir I. Vladimirov
Viktor E. Goldberg
Nataliya O. Popova
Marianna V. Kibisheva
Zaur M. Khamgokov
Alexey E. Vasilyev
Aglaya G. Iyevleva
Evgeny N. Imyanitov
The frequency and spectrum of PIK3CA mutations in patients with estrogen receptor-positive HER2-negative advanced breast cancer residing in various regions of Russia
description Relevance. PIK3CA belongs to the top three most frequently mutated genes in breast cancer (BC), especially in estrogen receptor (ER) positive, HER2 negative BC subtype. With an approval of selective PI3K-alpha inhibitor, alpelisib, this alteration has become actionable in ER+HER2- tumors. The frequency and spectrum of PIK3CA alterations in various cohorts is affected by a number of factors, including the distribution of BC expression subtypes, histological types, patient age, and even ethnicity. Aim. Aim of the current study was to characterize the frequency and spectrum of PIK3CA alterations in Russian BC patients. Materials and methods. The analysis of PIK3CA exon 7, 9 and 20 mutations was performed in a cohort of Russian ER+HER2- BC patients by a combination of high-resolution melting analysis, allele-specific PCR, and digital droplet PCR. Results. PIK3CA lesions were identified in 62/206 (30%) patients. Noteworthy, 59/62 (95%) of the identified variants were represented by the three most common p.E542K, p.E545K, and p.H1047R substitutions. The analysis of clinical and morphological characteristics revealed the trends towards association of PIK3CA mutations with older age and more frequent metastatic lung involvement. Conclusion. The obtained data on the frequency and spectrum of PIK3CA somatic aberrations can be helpful when organizing molecular genetic testing of breast cancer patients and using PI3K inhibitors in Russian population.
format article
author Tatiana N. Sokolova
Svetlana N. Aleksakhina
Grigoriy A. Yanus
Aleksandr V. Sultanbaev
Konstantin V. Menshikov
Anna N. Lysenko
Ruslan A. Zukov
Alena V. Zyuzyukina
Yulia N. Murunova
Elena I. Rossokha
Sergey Y. Bakharev
Elena A. Basova
Tatiana A. Kasmynina
Irina S. Shumskaya
Yana I. Bakshun
Khedi S. Musaeva
Alfia I. Khasanova
Vadim N. Dmitriev
Marina B. Bolieva
Christina H. Gadzaova
Oleg L. Petrenko
Dmitriy A. Maksimov
Vladimir I. Vladimirov
Viktor E. Goldberg
Nataliya O. Popova
Marianna V. Kibisheva
Zaur M. Khamgokov
Alexey E. Vasilyev
Aglaya G. Iyevleva
Evgeny N. Imyanitov
author_facet Tatiana N. Sokolova
Svetlana N. Aleksakhina
Grigoriy A. Yanus
Aleksandr V. Sultanbaev
Konstantin V. Menshikov
Anna N. Lysenko
Ruslan A. Zukov
Alena V. Zyuzyukina
Yulia N. Murunova
Elena I. Rossokha
Sergey Y. Bakharev
Elena A. Basova
Tatiana A. Kasmynina
Irina S. Shumskaya
Yana I. Bakshun
Khedi S. Musaeva
Alfia I. Khasanova
Vadim N. Dmitriev
Marina B. Bolieva
Christina H. Gadzaova
Oleg L. Petrenko
Dmitriy A. Maksimov
Vladimir I. Vladimirov
Viktor E. Goldberg
Nataliya O. Popova
Marianna V. Kibisheva
Zaur M. Khamgokov
Alexey E. Vasilyev
Aglaya G. Iyevleva
Evgeny N. Imyanitov
author_sort Tatiana N. Sokolova
title The frequency and spectrum of PIK3CA mutations in patients with estrogen receptor-positive HER2-negative advanced breast cancer residing in various regions of Russia
title_short The frequency and spectrum of PIK3CA mutations in patients with estrogen receptor-positive HER2-negative advanced breast cancer residing in various regions of Russia
title_full The frequency and spectrum of PIK3CA mutations in patients with estrogen receptor-positive HER2-negative advanced breast cancer residing in various regions of Russia
title_fullStr The frequency and spectrum of PIK3CA mutations in patients with estrogen receptor-positive HER2-negative advanced breast cancer residing in various regions of Russia
title_full_unstemmed The frequency and spectrum of PIK3CA mutations in patients with estrogen receptor-positive HER2-negative advanced breast cancer residing in various regions of Russia
title_sort frequency and spectrum of pik3ca mutations in patients with estrogen receptor-positive her2-negative advanced breast cancer residing in various regions of russia
publisher IP Habib O.N.
publishDate 2021
url https://doaj.org/article/49ac17b627194a6ea7e6222ff26d5a94
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