Stage-dependent effects of intermittent hypoxia influence the outcome of hippocampal adult neurogenesis

Abstract Over one billion adults worldwide are estimated to suffer from sleep apnea, a condition with wide-reaching effects on brain health. Sleep apnea causes cognitive decline and is a risk factor for neurodegenerative conditions such as Alzheimer’s disease. Rodents exposed to intermittent hypoxia...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Maggie A. Khuu, Thara Nallamothu, Carolina I. Castro-Rivera, Alejandra Arias-Cavieres, Caroline C. Szujewski, Alfredo J. Garcia III
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/49b30e726a4947548ac3b1fe3b099cd5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:49b30e726a4947548ac3b1fe3b099cd5
record_format	dspace
spelling	oai:doaj.org-article:49b30e726a4947548ac3b1fe3b099cd52021-12-02T16:31:14ZStage-dependent effects of intermittent hypoxia influence the outcome of hippocampal adult neurogenesis10.1038/s41598-021-85357-52045-2322https://doaj.org/article/49b30e726a4947548ac3b1fe3b099cd52021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85357-5https://doaj.org/toc/2045-2322Abstract Over one billion adults worldwide are estimated to suffer from sleep apnea, a condition with wide-reaching effects on brain health. Sleep apnea causes cognitive decline and is a risk factor for neurodegenerative conditions such as Alzheimer’s disease. Rodents exposed to intermittent hypoxia (IH), a hallmark of sleep apnea, exhibit spatial memory deficits associated with impaired hippocampal neurophysiology and dysregulated adult neurogenesis. We demonstrate that IH creates a pro-oxidant condition that reduces the Tbr2+ neural progenitor pool early in the process, while also suppressing terminal differentiation of adult born neurons during late adult neurogenesis. We further show that IH-dependent cell-autonomous hypoxia inducible factor 1-alpha (HIF1a) signaling is activated in early neuroprogenitors and enhances the generation of adult born neurons upon termination of IH. Our findings indicate that oscillations in oxygen homeostasis, such as those found in sleep apnea, have complex stage-dependent influence over hippocampal adult neurogenesis.Maggie A. KhuuThara NallamothuCarolina I. Castro-RiveraAlejandra Arias-CavieresCaroline C. SzujewskiAlfredo J. Garcia IIINature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maggie A. Khuu Thara Nallamothu Carolina I. Castro-Rivera Alejandra Arias-Cavieres Caroline C. Szujewski Alfredo J. Garcia III Stage-dependent effects of intermittent hypoxia influence the outcome of hippocampal adult neurogenesis
description	Abstract Over one billion adults worldwide are estimated to suffer from sleep apnea, a condition with wide-reaching effects on brain health. Sleep apnea causes cognitive decline and is a risk factor for neurodegenerative conditions such as Alzheimer’s disease. Rodents exposed to intermittent hypoxia (IH), a hallmark of sleep apnea, exhibit spatial memory deficits associated with impaired hippocampal neurophysiology and dysregulated adult neurogenesis. We demonstrate that IH creates a pro-oxidant condition that reduces the Tbr2+ neural progenitor pool early in the process, while also suppressing terminal differentiation of adult born neurons during late adult neurogenesis. We further show that IH-dependent cell-autonomous hypoxia inducible factor 1-alpha (HIF1a) signaling is activated in early neuroprogenitors and enhances the generation of adult born neurons upon termination of IH. Our findings indicate that oscillations in oxygen homeostasis, such as those found in sleep apnea, have complex stage-dependent influence over hippocampal adult neurogenesis.
format	article
author	Maggie A. Khuu Thara Nallamothu Carolina I. Castro-Rivera Alejandra Arias-Cavieres Caroline C. Szujewski Alfredo J. Garcia III
author_facet	Maggie A. Khuu Thara Nallamothu Carolina I. Castro-Rivera Alejandra Arias-Cavieres Caroline C. Szujewski Alfredo J. Garcia III
author_sort	Maggie A. Khuu
title	Stage-dependent effects of intermittent hypoxia influence the outcome of hippocampal adult neurogenesis
title_short	Stage-dependent effects of intermittent hypoxia influence the outcome of hippocampal adult neurogenesis
title_full	Stage-dependent effects of intermittent hypoxia influence the outcome of hippocampal adult neurogenesis
title_fullStr	Stage-dependent effects of intermittent hypoxia influence the outcome of hippocampal adult neurogenesis
title_full_unstemmed	Stage-dependent effects of intermittent hypoxia influence the outcome of hippocampal adult neurogenesis
title_sort	stage-dependent effects of intermittent hypoxia influence the outcome of hippocampal adult neurogenesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/49b30e726a4947548ac3b1fe3b099cd5
work_keys_str_mv	AT maggieakhuu stagedependenteffectsofintermittenthypoxiainfluencetheoutcomeofhippocampaladultneurogenesis AT tharanallamothu stagedependenteffectsofintermittenthypoxiainfluencetheoutcomeofhippocampaladultneurogenesis AT carolinaicastrorivera stagedependenteffectsofintermittenthypoxiainfluencetheoutcomeofhippocampaladultneurogenesis AT alejandraariascavieres stagedependenteffectsofintermittenthypoxiainfluencetheoutcomeofhippocampaladultneurogenesis AT carolinecszujewski stagedependenteffectsofintermittenthypoxiainfluencetheoutcomeofhippocampaladultneurogenesis AT alfredojgarciaiii stagedependenteffectsofintermittenthypoxiainfluencetheoutcomeofhippocampaladultneurogenesis
_version_	1718383869315514368

Stage-dependent effects of intermittent hypoxia influence the outcome of hippocampal adult neurogenesis

Ejemplares similares