ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes
Autophagy is an evolutionarily conserved vacuolar process functioning in the degradation of cellular components for reuse. In plants, autophagy is generally activated upon stress and its regulation is executed by numbers of AuTophaGy-related genes (ATGs), of which the ATG8 plays a dual role in both...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:49b66130dbe54866a2eb803f5c34d9b92021-12-01T13:06:37ZATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes1664-462X10.3389/fpls.2021.783881https://doaj.org/article/49b66130dbe54866a2eb803f5c34d9b92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpls.2021.783881/fullhttps://doaj.org/toc/1664-462XAutophagy is an evolutionarily conserved vacuolar process functioning in the degradation of cellular components for reuse. In plants, autophagy is generally activated upon stress and its regulation is executed by numbers of AuTophaGy-related genes (ATGs), of which the ATG8 plays a dual role in both biogenesis of autophagosomes and recruitment of ATG8-interacting motif (AIM) anchored selective autophagy receptors (SARs). Such motif is either termed as AIM or ubiquitin-interacting motif (UIM), corresponding to the LC3-interacting region (LIR)/AIM docking site (LDS) or the UIM docking site (UDS) of ATG8, respectively. To date, dozens of AIM or UIM containing SARs have been characterized. However, the knowledge of these motifs is still obscured. In this review, we intend to summarize the current understanding of SAR proteins and discuss the conservation and diversification of the AIMs/UIMs, expectantly providing new insights into the evolution of them in various biological processes in plants.Wanqing LiuWanqing LiuZinan LiuZulong MoShaoying GuoYunfeng LiuQingjun XieFrontiers Media S.A.articleautophagyATG8ATG8-interacting motif (AIM)ubiquitin-interacting motif (UIM)selective autophagy receptor (SAR)Plant cultureSB1-1110ENFrontiers in Plant Science, Vol 12 (2021) |
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| topic |
autophagy ATG8 ATG8-interacting motif (AIM) ubiquitin-interacting motif (UIM) selective autophagy receptor (SAR) Plant culture SB1-1110 |
| spellingShingle |
autophagy ATG8 ATG8-interacting motif (AIM) ubiquitin-interacting motif (UIM) selective autophagy receptor (SAR) Plant culture SB1-1110 Wanqing Liu Wanqing Liu Zinan Liu Zulong Mo Shaoying Guo Yunfeng Liu Qingjun Xie ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes |
| description |
Autophagy is an evolutionarily conserved vacuolar process functioning in the degradation of cellular components for reuse. In plants, autophagy is generally activated upon stress and its regulation is executed by numbers of AuTophaGy-related genes (ATGs), of which the ATG8 plays a dual role in both biogenesis of autophagosomes and recruitment of ATG8-interacting motif (AIM) anchored selective autophagy receptors (SARs). Such motif is either termed as AIM or ubiquitin-interacting motif (UIM), corresponding to the LC3-interacting region (LIR)/AIM docking site (LDS) or the UIM docking site (UDS) of ATG8, respectively. To date, dozens of AIM or UIM containing SARs have been characterized. However, the knowledge of these motifs is still obscured. In this review, we intend to summarize the current understanding of SAR proteins and discuss the conservation and diversification of the AIMs/UIMs, expectantly providing new insights into the evolution of them in various biological processes in plants. |
| format |
article |
| author |
Wanqing Liu Wanqing Liu Zinan Liu Zulong Mo Shaoying Guo Yunfeng Liu Qingjun Xie |
| author_facet |
Wanqing Liu Wanqing Liu Zinan Liu Zulong Mo Shaoying Guo Yunfeng Liu Qingjun Xie |
| author_sort |
Wanqing Liu |
| title |
ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes |
| title_short |
ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes |
| title_full |
ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes |
| title_fullStr |
ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes |
| title_full_unstemmed |
ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes |
| title_sort |
atg8-interacting motif: evolution and function in selective autophagy of targeting biological processes |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/49b66130dbe54866a2eb803f5c34d9b9 |
| work_keys_str_mv |
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