IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation

IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation

IL-6 is an important cytokine in the tumour microenvironment, but its role in regulating autophagy in cancer cells is unclear. Here the authors show that IL-6 activates autophagy in colorectal cancer through the interaction between JAK2 and autophagy regulator, BECN1, which leads to chemotherapeutic...

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Autores principales: Fuqing Hu, Da Song, Yumeng Yan, Changsheng Huang, Chentao Shen, Jingqin Lan, Yaqi Chen, Anyi Liu, Qi Wu, Li Sun, Feng Xu, Fayong Hu, Lisheng Chen, Xuelai Luo, Yongdong Feng, Shengyou Huang, Junbo Hu, Guihua Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/49b6d3166a0d4dc385c9d90171668cf8
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spelling oai:doaj.org-article:49b6d3166a0d4dc385c9d90171668cf82021-12-02T17:23:50ZIL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation10.1038/s41467-021-23923-12041-1723https://doaj.org/article/49b6d3166a0d4dc385c9d90171668cf82021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23923-1https://doaj.org/toc/2041-1723IL-6 is an important cytokine in the tumour microenvironment, but its role in regulating autophagy in cancer cells is unclear. Here the authors show that IL-6 activates autophagy in colorectal cancer through the interaction between JAK2 and autophagy regulator, BECN1, which leads to chemotherapeutic resistance.Fuqing HuDa SongYumeng YanChangsheng HuangChentao ShenJingqin LanYaqi ChenAnyi LiuQi WuLi SunFeng XuFayong HuLisheng ChenXuelai LuoYongdong FengShengyou HuangJunbo HuGuihua WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Fuqing Hu
Da Song
Yumeng Yan
Changsheng Huang
Chentao Shen
Jingqin Lan
Yaqi Chen
Anyi Liu
Qi Wu
Li Sun
Feng Xu
Fayong Hu
Lisheng Chen
Xuelai Luo
Yongdong Feng
Shengyou Huang
Junbo Hu
Guihua Wang
IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation
description IL-6 is an important cytokine in the tumour microenvironment, but its role in regulating autophagy in cancer cells is unclear. Here the authors show that IL-6 activates autophagy in colorectal cancer through the interaction between JAK2 and autophagy regulator, BECN1, which leads to chemotherapeutic resistance.
format article
author Fuqing Hu
Da Song
Yumeng Yan
Changsheng Huang
Chentao Shen
Jingqin Lan
Yaqi Chen
Anyi Liu
Qi Wu
Li Sun
Feng Xu
Fayong Hu
Lisheng Chen
Xuelai Luo
Yongdong Feng
Shengyou Huang
Junbo Hu
Guihua Wang
author_facet Fuqing Hu
Da Song
Yumeng Yan
Changsheng Huang
Chentao Shen
Jingqin Lan
Yaqi Chen
Anyi Liu
Qi Wu
Li Sun
Feng Xu
Fayong Hu
Lisheng Chen
Xuelai Luo
Yongdong Feng
Shengyou Huang
Junbo Hu
Guihua Wang
author_sort Fuqing Hu
title IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation
title_short IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation
title_full IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation
title_fullStr IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation
title_full_unstemmed IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation
title_sort il-6 regulates autophagy and chemotherapy resistance by promoting becn1 phosphorylation
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/49b6d3166a0d4dc385c9d90171668cf8
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