Pleiotropic effects of fenofibrate: focus on type 2 diabetes mellitus

Aims. The aim of the present study was to investigate the role of chronic low-grade inflammation in the development of the diabetic neuropathy and the possibility of its medical treatment with fenofibrate (145 mg/day). Materials and Methods. This trial included 60 patients with type 2 diabetes mel...

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Autores principales:	Alexander Sergeevich Ametov, Marina Alexandrovna Prudnikova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2014
Materias:	diabetes mellitus low-grade inflammation neuropathy fenofibrate Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/49b75ff6934947ababd693666d252a3e
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spelling	oai:doaj.org-article:49b75ff6934947ababd693666d252a3e2021-11-14T09:00:19ZPleiotropic effects of fenofibrate: focus on type 2 diabetes mellitus2072-03512072-037810.14341/DM2014443-50https://doaj.org/article/49b75ff6934947ababd693666d252a3e2014-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6669https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aims. The aim of the present study was to investigate the role of chronic low-grade inflammation in the development of the diabetic neuropathy and the possibility of its medical treatment with fenofibrate (145 mg/day). Materials and Methods. This trial included 60 patients with type 2 diabetes mellitus. The serum levels of several factors were measured: tumour necrosis factor-? (TNF-?), interleukin-1? (IL-1?), interleukin-6 (IL-6), C-reactive protein (CRP), markers of oxidative stress (malondialdehyde levels), haemostasis, uric acid, glycaemic and lipid profile and the peripheral status (electromyography, total symptom score [TSS] and neuropathy impairment score in the lower limbs [NIS-LL]). Follow-up was at 24 weeks. Results. A significant negative correlation was found between the excitation rate of the sural nerve and levels of TNF, IL-6 and CRP (pAlexander Sergeevich AmetovMarina Alexandrovna PrudnikovaEndocrinology Research Centrearticlediabetes mellituslow-grade inflammationneuropathyfenofibrateNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 17, Iss 4, Pp 43-50 (2014)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus low-grade inflammation neuropathy fenofibrate Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus low-grade inflammation neuropathy fenofibrate Nutritional diseases. Deficiency diseases RC620-627 Alexander Sergeevich Ametov Marina Alexandrovna Prudnikova Pleiotropic effects of fenofibrate: focus on type 2 diabetes mellitus
description	Aims. The aim of the present study was to investigate the role of chronic low-grade inflammation in the development of the diabetic neuropathy and the possibility of its medical treatment with fenofibrate (145 mg/day). Materials and Methods. This trial included 60 patients with type 2 diabetes mellitus. The serum levels of several factors were measured: tumour necrosis factor-? (TNF-?), interleukin-1? (IL-1?), interleukin-6 (IL-6), C-reactive protein (CRP), markers of oxidative stress (malondialdehyde levels), haemostasis, uric acid, glycaemic and lipid profile and the peripheral status (electromyography, total symptom score [TSS] and neuropathy impairment score in the lower limbs [NIS-LL]). Follow-up was at 24 weeks. Results. A significant negative correlation was found between the excitation rate of the sural nerve and levels of TNF, IL-6 and CRP (p
format	article
author	Alexander Sergeevich Ametov Marina Alexandrovna Prudnikova
author_facet	Alexander Sergeevich Ametov Marina Alexandrovna Prudnikova
author_sort	Alexander Sergeevich Ametov
title	Pleiotropic effects of fenofibrate: focus on type 2 diabetes mellitus
title_short	Pleiotropic effects of fenofibrate: focus on type 2 diabetes mellitus
title_full	Pleiotropic effects of fenofibrate: focus on type 2 diabetes mellitus
title_fullStr	Pleiotropic effects of fenofibrate: focus on type 2 diabetes mellitus
title_full_unstemmed	Pleiotropic effects of fenofibrate: focus on type 2 diabetes mellitus
title_sort	pleiotropic effects of fenofibrate: focus on type 2 diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2014
url	https://doaj.org/article/49b75ff6934947ababd693666d252a3e
work_keys_str_mv	AT alexandersergeevichametov pleiotropiceffectsoffenofibratefocusontype2diabetesmellitus AT marinaalexandrovnaprudnikova pleiotropiceffectsoffenofibratefocusontype2diabetesmellitus
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Pleiotropic effects of fenofibrate: focus on type 2 diabetes mellitus

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